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Hepatology

Cover image for Vol. 55 Issue 1

January 2012

Volume 55, Issue 1

Pages 1–331

  1. Editor's Corner

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
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      Something old, something new (pages 1–2)

      Michael H. Nathanson

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24817

  2. Master's Perspective

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
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      Dealing with stress (pages 3–13)

      Neil Kaplowitz

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.25515

  3. Editorials

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
    2. You have free access to this content
  4. Viral Hepatitis

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
      Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response (pages 20–29)

      Yasuhiro Asahina, Kaoru Tsuchiya, Masaru Muraoka, Keisuke Tanaka, Yuichiro Suzuki, Nobuharu Tamaki, Yoshihide Hoshioka, Yutaka Yasui, Tomoji Katoh, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Sayuri Nitta, Naoya Sakamoto and Namiki Izumi

      Article first published online: 29 NOV 2011 | DOI: 10.1002/hep.24623

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      Treatment of chronic hepatitis C genotype 1 patients at an academic center in europe involved in prospective, controlled trials: Is there a selection bias? (pages 30–38)

      Sandra Beinhardt, Albert F. Staettermayer, Karoline Rutter, Judith Maresch, Thomas M. Scherzer, Petra Steindl-Munda, Harald Hofer and Peter Ferenci

      Article first published online: 30 NOV 2011 | DOI: 10.1002/hep.24671

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      Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients (pages 39–48)

      Birgit Edlich, Golo Ahlenstiel, Aintzane Azpiroz Zabaleta, Jonathan Stoltzfus, Mazen Noureddin, Elisavet Serti, Jordan J. Feld, T. Jake Liang, Yaron Rotman and Barbara Rehermann

      Article first published online: 14 NOV 2011 | DOI: 10.1002/hep.24628

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      Cost-effectiveness of hepatitis C virus antiviral treatment for injection drug user populations (pages 49–57)

      Natasha K. Martin, Peter Vickerman, Alec Miners, Graham R. Foster, Sharon J. Hutchinson, David J. Goldberg and Matthew Hickman

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24656

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      Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive (pages 58–67)

      Jérôme Boursier, Victor de Ledinghen, Jean-Pierre Zarski, Isabelle Fouchard-Hubert, Yves Gallois, Frédéric Oberti, Paul Calès and multicentric groups from SNIFF 32, VINDIAG 7, and ANRS/HC/EP23 FIBROSTAR studies

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24654

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      Determinants of spontaneous surface antigen loss in hepatitis B e antigen–negative patients with a low viral load (pages 68–76)

      Tai-Chung Tseng, Chun-Jen Liu, Hung-Chih Yang, Tung-Hung Su, Chia-Chi Wang, Chi-Ling Chen, Stephanie Fang-Tzu Kuo, Chen-Hua Liu, Pei-Jer Chen, Ding-Shinn Chen and Jia-Horng Kao

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24615

  5. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
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      Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease (pages 77–85)

      Kris V. Kowdley, Patricia Belt, Laura A. Wilson, Matthew M. Yeh, Brent A. Neuschwander-Tetri, Naga Chalasani, Arun J. Sanyal, James E. Nelson and for the NASH Clinical Research Network.

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24706

  6. Hepatobiliary Malignancies

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6 (pages 98–107)

      Jan Krützfeldt, Nora Rösch, Jean Hausser, Muthiah Manoharan, Mihaela Zavolan and Markus Stoffel

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24658

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      Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice (pages 108–120)

      Chao Wang, Wen Yang, He-Xin Yan, Tao Luo, Jian Zhang, Liang Tang, Fu-Quan Wu, Hui-Lu Zhang, Le-Xing Yu, Long-Yi Zheng, Yu-Qiong Li, Wei Dong, Ya-Qin He, Qiong Liu, Shan-Shan Zou, Yan Lin, Liang Hu, Zhong Li, Meng-Chao Wu and Hong-Yang Wang

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24675

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      Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss (pages 121–131)

      Shelli M. Morris, Ji Yeon Baek, Amanda Koszarek, Samornmas Kanngurn, Sue E. Knoblaugh and William M. Grady

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24653

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  7. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
      Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model (pages 141–152)

      Diego M. Avella, Guangfu Li, Todd D. Schell, Dai Liu, Samuel Shao-Min Zhang, Xi Lou, Arthur Berg, Eric T. Kimchi, Hephzibah Rani S. Tagaram, Qing Yang, Serene Shereef, Luis S. Garcia, Mark Kester, Harriet C. Isom, C. Bart Rountree and Kevin F. Staveley-O'Carroll

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24652

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      Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis (pages 153–160)

      Ana Lleo, Jieyue Liao, Pietro Invernizzi, Ming Zhao, Francesca Bernuzzi, Le Ma, Gaetana Lanzi, Aftab A. Ansari, Ross L. Coppel, Peng Zhang, Yijun Li, Zhiguang Zhou, Qianjin Lu and M. Eric Gershwin

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24630

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      Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation (pages 161–172)

      Hsiang-Po Huang, Mei-Hwei Chang, Yi-Tzu Chen, Hong-Yuan Hsu, Cheng-Lun Chiang, Tai-Shan Cheng, Yao-Ming Wu, Mu Zon Wu, Yu-Chen Hsu, Chih-Che Shen, Chun-Nan Lee, Ya-Hui Chuang, Chia-Lun Hong, Yung-Ming Jeng, Pin-Hsun Chen, Huey-Ling Chen and Ming-Shyue Lee

      Article first published online: 16 NOV 2011 | DOI: 10.1002/hep.24657

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      A biliary HCO3 umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes (pages 173–183)

      Simon Hohenester, Lucas Maillette de Buy Wenniger, Coen C. Paulusma, Sandra J. van Vliet, Douglas M. Jefferson, Ronald P. Oude Elferink and Ulrich Beuers

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24691

  8. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
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      Burden of cirrhosis on older Americans and their families: Analysis of the health and retirement study (pages 184–191)

      Mina O. Rakoski, Ryan J. McCammon, John D. Piette, Theodore J. Iwashyna, Jorge A. Marrero, Anna S. Lok, Kenneth M. Langa and Michael L. Volk

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24616

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      Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients (pages 199–208)

      Robert P. Myers, Gilles Pomier-Layrargues, Richard Kirsch, Aaron Pollett, Andres Duarte-Rojo, David Wong, Melanie Beaton, Mark Levstik, Pam Crotty and Magdy Elkashab

      Article first published online: 18 NOV 2011 | DOI: 10.1002/hep.24624

  9. Liver Injury/Regeneration

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
      Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration (pages 209–221)

      Fanyin Meng, Heather Francis, Shannon Glaser, Yuyan Han, Sharon DeMorrow, Allison Stokes, Dustin Staloch, Julie Venter, Melanie White, Yoshiyuki Ueno, Lola M. Reid and Gianfranco Alpini

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24673

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      Activation of autophagy protects against acetaminophen-induced hepatotoxicity (pages 222–232)

      Hong-Min Ni, Abigail Bockus, Nikki Boggess, Hartmut Jaeschke and Wen-Xing Ding

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24690

  10. Liver Biology/Pathobiology

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Dendritic cell regulation of carbon tetrachloride–induced murine liver fibrosis regression (pages 244–255)

      Jingjing Jiao, David Sastre, Maria Isabel Fiel, Ursula E. Lee, Zahra Ghiassi-Nejad, Florent Ginhoux, Eric Vivier, Scott L. Friedman, Miriam Merad and Costica Aloman

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24621

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      Glucocorticoids increase interleukin-6–dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor (pages 256–266)

      Anna Dittrich, Christina Khouri, Sara Dutton Sackett, Christian Ehlting, Oliver Böhmer, Ute Albrecht, Johannes G. Bode, Christian Trautwein and Fred Schaper

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24655

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      Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes (pages 267–276)

      Elaine Studer, Xiqiao Zhou, Renping Zhao, Yun Wang, Kazuaki Takabe, Masayuki Nagahashi, William M. Pandak, Paul Dent, Sarah Spiegel, Ruihua Shi, Weiren Xu, Xuyuan Liu, Pat Bohdan, Luyong Zhang, Huiping Zhou and Phillip B. Hylemon

      Article first published online: 30 NOV 2011 | DOI: 10.1002/hep.24681

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      Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance (pages 277–286)

      Yiping Deng, Erin M. Foley, Jon C. Gonzales, Philip L. Gordts, Yulin Li and Jeffrey D. Esko

      Article first published online: 6 DEC 2011 | DOI: 10.1002/hep.24626

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      Toll-like receptor 2–mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors (pages 287–297)

      Marianna Hösel, Mathias Broxtermann, Hanna Janicki, Knud Esser, Silke Arzberger, Pia Hartmann, Sonja Gillen, Jörg Kleeff, Dirk Stabenow, Margarete Odenthal, Percy Knolle, Michael Hallek, Ulrike Protzer and Hildegard Büning

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24625

  11. Reviews

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
  12. Meeting Reports

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
  13. Hepatology Elsewhere

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
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      Sharpen your look on liver progenitor cells (pages 319–321)

      Laurent Dollé, Konrad L. Streetz and Leo A. van Grunsven

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24727

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  14. Clinical Observations in Hepatology

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
      Amiodarone Hepatotoxicity (pages 325–326)

      Pil Soo Sung and Seung Kew Yoon

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24627

  15. Correspondence

    1. Top of page
    2. Editor's Corner
    3. Master's Perspective
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. Reviews
    13. Meeting Reports
    14. Hepatology Elsewhere
    15. Clinical Observations in Hepatology
    16. Correspondence
    1. You have free access to this content
      Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China (pages 327–328)

      Yiling Li, Chao Xing, Jonathan C. Cohen and Helen H. Hobbs

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24659

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      Staging hepatic fibrosis: Computer-aided analysis of hepatic contours on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced hepatocyte-phase magnetic resonance imaging (pages 328–329)

      Satoshi Goshima, Masayuki Kanematsu, Tatsunori Kobayashi, Takahiro Furukawa, Xuejun Zhang, Hiroshi Fujita, Haruo Watanabe, Hiroshi Kondo, Noriyuki Moriyama and Kyongtae T. Bae

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24677

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      Mean platelet volume as a marker of increased cardiovascular risk in patients with nonalcoholic steatohepatitis (page 331)

      Naim Alkhouri, Gaurav Kistangari, Carla Campbell, Rocio Lopez, Nizar N. Zein and Ariel E. Feldstein

      Article first published online: 21 DEC 2011 | DOI: 10.1002/hep.24721

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