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Hepatology

Cover image for Vol. 55 Issue 2

February 2012

Volume 55, Issue 2

Pages 333–658

  1. Editorials

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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  2. Viral Hepatitis

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4 (pages 336–342)

      Stella De Nicola, Alessio Aghemo, Maria Grazia Rumi, Enrico Galmozzi, Luca Valenti, Roberta Soffredini, Raffaele De Francesco, Gian Maria Prati, Roberta D'Ambrosio, Cristina Cheroni, Maria Francesca Donato and Massimo Colombo

      Article first published online: 3 JAN 2012 | DOI: 10.1002/hep.24683

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      Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species (pages 343–353)

      Robert S. Tacke, Hai-Chon Lee, Celeste Goh, Jeremy Courtney, Stephen J. Polyak, Hugo R. Rosen and Young S. Hahn

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24700

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      CD59 incorporation protects hepatitis C virus against complement-mediated destruction (pages 354–363)

      Tohti Amet, Marwan Ghabril, Naga Chalasani, Daniel Byrd, Ningjie Hu, Ayslinn Grantham, Ziqing Liu, Xuebin Qin, Johnny J. He and Qigui Yu

      Article first published online: 16 DEC 2011 | DOI: 10.1002/hep.24686

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      A Human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo (pages 364–372)

      Philip Meuleman, Maria Teresa Catanese, Lieven Verhoye, Isabelle Desombere, Ali Farhoudi, Christopher T. Jones, Timothy Sheahan, Katarzyna Grzyb, Riccardo Cortese, Charles M. Rice, Geert Leroux-Roels and Alfredo Nicosia

      Article first published online: 16 DEC 2011 | DOI: 10.1002/hep.24692

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      IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes (pages 384–394)

      Pierre-Yves Bochud, Stéphanie Bibert, Zoltán Kutalik, Etienne Patin, Julien Guergnon, Bertrand Nalpas, Nicolas Goossens, Lorenz Kuske, Beat Müllhaupt, Tillman Gerlach, Markus H. Heim, Darius Moradpour, Andreas Cerny, Raffaele Malinverni, Stephan Regenass, Guenter Dollenmaier, Hans Hirsch, Gladys Martinetti, Meri Gorgiewski, Marc Bourlière, Thierry Poynard, Ioannis Theodorou, Laurent Abel, Stanislas Pol, Jean-François Dufour, Francesco Negro and on behalf of the Swiss Hepatitis C Cohort Study Group the ANRS HC EP 26 Genoscan Study Group

      Article first published online: 16 DEC 2011 | DOI: 10.1002/hep.24678

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      Low doses of bisphenol a induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver (pages 395–407)

      Alice Marmugi, Simon Ducheix, Frédéric Lasserre, Arnaud Polizzi, Alain Paris, Nathalie Priymenko, Justine Bertrand-Michel, Thierry Pineau, Hervé Guillou, Pascal G.P. Martin and Laïla Mselli-Lakhal

      Article first published online: 22 DEC 2011 | DOI: 10.1002/hep.24685

  3. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival (pages 408–418)

      Matthias Fuest, Karolina Willim, Sabine MacNelly, Nicole Fellner, Guenter P. Resch, Hubert E. Blum and Peter Hasselblatt

      Article first published online: 16 DEC 2011 | DOI: 10.1002/hep.24699

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      A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis (pages 419–428)

      Vlad Ratziu, Muhammad Y. Sheikh, Arun J. Sanyal, Joseph K. Lim, Hari Conjeevaram, Naga Chalasani, Manal Abdelmalek, Anezi Bakken, Christophe Renou, Melissa Palmer, Robert A. Levine, B. Raj Bhandari, Melanie Cornpropst, Wei Liang, Benjamin King, Elsa Mondou, Franck S. Rousseau, John McHutchison and Mario Chojkier

      Article first published online: 14 DEC 2011 | DOI: 10.1002/hep.24747

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      Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis (pages 429–436)

      Jeffrey W. Molloy, Christopher J. Calcagno, Christopher D. Williams, Frances J. Jones, Dawn M. Torres and Stephen A. Harrison

      Article first published online: 22 DEC 2011 | DOI: 10.1002/hep.24731

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      Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice (pages 437–446)

      Ming Hu, Fengming Wang, Xin Li, Christopher Q. Rogers, Xiaomei Liang, Brian N. Finck, Mayurranjan S. Mitra, Ray Zhang, Dave A. Mitchell and Min You

      Article first published online: 29 DEC 2011 | DOI: 10.1002/hep.24708

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      Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis (pages 455–464)

      Diana Joka, Kristin Wahl, Sarah Moeller, Jerome Schlue, Bernhard Vaske, Matthias J. Bahr, Michael P. Manns, Klaus Schulze-Osthoff and Heike Bantel

      Article first published online: 29 NOV 2011 | DOI: 10.1002/hep.24734

  4. Hepatobiliary Malignancies

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma (pages 465–475)

      Nataliya Razumilava, Steve F. Bronk, Rory L. Smoot, Christian D. Fingas, Nathan W. Werneburg, Lewis R. Roberts and Justin L. Mott

      Article first published online: 19 DEC 2011 | DOI: 10.1002/hep.24698

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      Identification of osteopontin as a novel marker for early hepatocellular carcinoma (pages 483–490)

      Sufen Shang, Amelie Plymoth, Shaokui Ge, Ziding Feng, Hugo R. Rosen, Suleeporn Sangrajrang, Pierre Hainaut, Jorge A. Marrero and Laura Beretta

      Article first published online: 19 DEC 2011 | DOI: 10.1002/hep.24703

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      Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development (pages 491–505)

      Tim Hon Man Chan, Leilei Chen, Ming Liu, Liang Hu, Bo-jian Zheng, Vincent Kwok-Man Poon, Pinzhu Huang, Yun-Fei Yuan, Jian-dong Huang, Jie Yang, George Sai-wah Tsao and Xin-Yuan Guan

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24709

  5. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis (pages 506–511)

      Takeji Umemura, Satoru Joshita, Tetsuya Ichijo, Kaname Yoshizawa, Yoshihiko Katsuyama, Eiji Tanaka, Masao Ota and The Shinshu PBC Study Group

      Article first published online: 19 DEC 2011 | DOI: 10.1002/hep.24705

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      Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid (pages 512–521)

      Masanobu Tsuda, Yuki Moritoki, Zhe-Xiong Lian, Weici Zhang, Katsunori Yoshida, Kanji Wakabayashi, Guo-Xiang Yang, Toshio Nakatani, John Vierling, Keith Lindor, M. Eric Gershwin and Christopher L. Bowlus

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24748

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      Mortality and the risk of malignancy in autoimmune liver diseases: A population-based study in Canterbury, New Zealand (pages 522–529)

      Jing Hieng Ngu, Richard Blair Gearry, Chris Miles Frampton and Catherine Ann Malcolm Stedman

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24743

  6. Liver Failure, Cirrhosis and Portal Hypertension

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests (pages 530–539)

      Vicente Felipo, Juan F. Ordoño, Amparo Urios, Nisrin El Mlili, Carla Giménez-Garzó, Carolina Aguado, Olga González-Lopez, Remedios Giner-Duran, Miguel A. Serra, Abdallah Wassel, Jose M. Rodrigo, José Salazar and Carmina Montoliu

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24704

  7. Liver Injury and Regeneration

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice (pages 540–552)

      Laurent Dollé, Jan Best, Christophe Empsen, Jie Mei, Elke Van Rossen, Philip Roelandt, Sarah Snykers, Mustapha Najimi, Feras Al Battah, Neil D. Theise, Konrad Streetz, Etienne Sokal, Isabelle A. Leclercq, Catherine Verfaillie, Vera Rogiers, Albert Geerts and Leo A. van Grunsven

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24693

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      Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice (pages 553–562)

      Roja Barikbin, Daniel Neureiter, Jan Wirth, Annette Erhardt, Dorothee Schwinge, Johannes Kluwe, Christoph Schramm, Gisa Tiegs and Gabriele Sass

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24711

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  8. Liver Biology/Pathobiology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract (pages 575–583)

      Serge J.L.B. Zweers, Klaske A.C. Booij, Mina Komuta, Tania Roskams, Dirk J. Gouma, Peter L.M. Jansen and Frank G. Schaap

      Article first published online: 19 DEC 2011 | DOI: 10.1002/hep.24702

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      “Normal” liver stiffness measure (LSM) values are higher in both lean and obese individuals: A population-based study from a developing country (pages 584–593)

      Kausik Das, Rajib Sarkar, Sk. Mahiuddin Ahmed, Asit R. Mridha, Partha S. Mukherjee, Kshaunish Das, Gopal K. Dhali, Amal Santra and Abhijit Chowdhury

      Article first published online: 29 DEC 2011 | DOI: 10.1002/hep.24694

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      Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling (pages 594–608)

      Raquel Urtasun, Aritz Lopategi, Joseph George, Tung-Ming Leung, Yongke Lu, Xiaodong Wang, Xiaodong Ge, Maria Isabel Fiel and Natalia Nieto

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24701

  9. Liver Biology and Pathobiology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      A mouse model of accelerated liver aging caused by a defect in DNA repair (pages 609–621)

      Siobhán Q. Gregg, Verónica Gutiérrez, Andria Rasile Robinson, Tyler Woodell, Atsunori Nakao, Mark A. Ross, George K. Michalopoulos, Lora Rigatti, Carrie E. Rothermel, Irene Kamileri, George A. Garinis, Donna Beer Stolz and Laura J. Niedernhofer

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24713

  10. New Horizons

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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  11. Reviews

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
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      Hepatitis C and non-Hodgkin lymphoma: The clinical perspective (pages 634–641)

      Sidonie K. Hartridge-Lambert, Eytan M. Stein, Arnold J. Markowitz and Carol S. Portlock

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.25499

  12. Hepatology Elsewhere

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
    1. You have free access to this content
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  13. Clinical Observations in Hepatology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
    1. You have free access to this content
  14. Correspondence

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
    1. You have free access to this content
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      Reply: (page 652)

      Korosh Khalili and Morris Sherman

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.24779

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      Reply: (page 653)

      Jérôme Boursier and Paul Calès

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.25526

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      Reply: (pages 654–655)

      Heike Bantel, Matthias J. Bahr, Jerome Schlue and Klaus Schulze-Osthoff

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.25525

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  15. In Memoriam

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure, Cirrhosis and Portal Hypertension
    8. Liver Injury and Regeneration
    9. Liver Biology/Pathobiology
    10. Liver Biology and Pathobiology
    11. New Horizons
    12. Reviews
    13. Hepatology Elsewhere
    14. Clinical Observations in Hepatology
    15. Correspondence
    16. In Memoriam
    1. You have free access to this content
      In Memoriam: Harold O. Conn, M.D. (page 658)

      James L. Boyer, Guadalupe Garcia-Tsao and Roberto J. Groszmann

      Article first published online: 27 JAN 2012 | DOI: 10.1002/hep.25550

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