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Hepatology

Cover image for Vol. 55 Issue 3

March 2012

Volume 55, Issue 3

Pages 661–983

  1. Editorials

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms (pages 661–663)

      Luca Valenti, Anna Alisi and Valerio Nobili

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25617

      Corrected by:

      Correction: Correction

      Vol. 55, Issue 4, 1311, Article first published online: 20 MAR 2012

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  2. Viral Hepatitis

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Activation of chemokine and inflammatory cytokine response in hepatitis C virus–infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates (pages 666–675)

      Kui Li, Nan L. Li, Dahai Wei, Susan R. Pfeffer, Meiyun Fan and Lawrence M. Pfeffer

      Article first published online: 30 JAN 2012 | DOI: 10.1002/hep.24763

      Corrected by:

      Correction: Corrections

      Vol. 56, Issue 1, 397, Article first published online: 3 JUL 2012

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      Two distinct subtypes of hepatitis B virus–related acute liver failure are separable by quantitative serum immunoglobulin M anti-hepatitis B core antibody and hepatitis B virus DNA levels (pages 676–684)

      Doan Y. Dao, Linda S. Hynan, He-Jun Yuan, Corron Sanders, Jody Balko, Nahid Attar, Anna S.F. Lok, R. Ann Word, William M. Lee and the Acute Liver Failure Study Group

      Article first published online: 31 JAN 2012 | DOI: 10.1002/hep.24732

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      Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation (pages 685–694)

      Marc Lütgehetmann, Lida V. Mancke, Tassilo Volz, Martina Helbig, Lena Allweiss, Till Bornscheuer, Joerg M. Pollok, Ansgar W. Lohse, J. Petersen, Stephan Urban and Maura Dandri

      Article first published online: 30 JAN 2012 | DOI: 10.1002/hep.24758

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      Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection (pages 695–708)

      Pothakamuri Venkata Suneetha, Sven Pischke, Verena Schlaphoff, Jan Grabowski, Paraskevi Fytili, Anna Gronert, Birgit Bremer, Antoaneta Markova, Jerzy Jaroszewicz, Christoph Bara, Michael P. Manns, Markus Cornberg and Heiner Wedemeyer

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24738

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      (−)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry (pages 720–729)

      Noémie Calland, Anna Albecka, Sandrine Belouzard, Czeslaw Wychowski, Gilles Duverlie, Véronique Descamps, Didier Hober, Jean Dubuisson, Yves Rouillé and Karin Séron

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24803

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      Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity (pages 730–741)

      Saifeng Wang, Lipeng Qiu, Xiaoli Yan, Wensong Jin, Yanzhong Wang, Lizhao Chen, Erjie Wu, Xin Ye, George F. Gao, Fusheng Wang, Yu Chen, Zhongping Duan and Songdong Meng

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24809

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      Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b–infected null responders (pages 742–748)

      Kazuaki Chayama, Shoichi Takahashi, Joji Toyota, Yoshiyasu Karino, Kenji Ikeda, Hiroki Ishikawa, Hideaki Watanabe, Fiona McPhee, Eric Hughes and Hiromitsu Kumada

      Article first published online: 30 JAN 2012 | DOI: 10.1002/hep.24724

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      The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C (pages 749–758)

      Stefan Zeuzem, Peter Buggisch, Kosh Agarwal, Patrick Marcellin, Daniel Sereni, Hartwig Klinker, Christophe Moreno, Jean-Pierre Zarski, Yves Horsmans, Hongmei Mo, Sarah Arterburn, Steven Knox, David Oldach, John G. McHutchison, Michael P. Manns and Graham R. Foster

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24744

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      Higher serum testosterone is associated with increased risk of advanced hepatitis C–related liver disease in males (pages 759–768)

      Donna L. White, Shariar Tavakoli-Tabasi, Jill Kuzniarek, Rhia Pascua, David J. Ramsey and Hashem B. El-Serag

      Article first published online: 14 DEC 2011 | DOI: 10.1002/hep.24618

  3. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Ethnicity and nonalcoholic fatty liver disease (pages 769–780)

      Kiran Bambha, Patricia Belt, Maria Abraham, Laura A. Wilson, Mark Pabst, Linda Ferrell, Aynur Unalp-Arida, Nathan Bass and for the Nonalcoholic Steatohepatitis Clinical Research Network Research Group

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24726

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      Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents (pages 781–789)

      Nicola Santoro, Clarence K. Zhang, Hongyu Zhao, Andrew J. Pakstis, Grace Kim, Romy Kursawe, Daniel J. Dykas, Allen E. Bale, Cosimo Giannini, Bridget Pierpont, Melissa M. Shaw, Leif Groop and Sonia Caprio

      Article first published online: 18 DEC 2011 | DOI: 10.1002/hep.24806

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      Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants (pages 790–799)

      Tony Jourdan, Laurent Demizieux, Joseph Gresti, Louiza Djaouti, Lila Gaba, Bruno Vergès and Pascal Degrace

      Article first published online: 30 JAN 2012 | DOI: 10.1002/hep.24733

  4. Hepatobiliary Malignancies

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Accuracy and disagreement of computed tomography and magnetic resonance imaging for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: Role of biopsy (pages 800–806)

      Thomas Sersté, Vincent Barrau, Violaine Ozenne, Marie-Pierre Vullierme, Pierre Bedossa, Olivier Farges, Dominique-Charles Valla, Valérie Vilgrain, Valérie Paradis and Françoise Degos

      Article first published online: 30 JAN 2012 | DOI: 10.1002/hep.24746

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      CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling (pages 807–820)

      Kwan Ho Tang, Stephanie Ma, Terence K. Lee, Yuen Piu Chan, Pak Shing Kwan, Carol M. Tong, Irene O. Ng, Kwan Man, Ka-Fai To, Paul B. Lai, Chung-Mau Lo, Xin-Yuan Guan and Kwok Wah Chan

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24739

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      Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs (pages 821–832)

      Florie Borel, Ruiqi Han, Allerdien Visser, Harald Petry, Sander J.H. van Deventer, Peter L.M. Jansen, Pavlina Konstantinova and with collaboration of the Réseau Centre de Ressources Biologiques Foie (French Liver Biobanks Network), France

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24682

  5. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways (pages 833–845)

      Coral Ho, Chunmei Wang, Sandra Mattu, Giulia Destefanis, Sara Ladu, Salvatore Delogu, Julia Armbruster, Lingling Fan, Susie A. Lee, Lijie Jiang, Frank Dombrowski, Matthias Evert, Xin Chen and Diego F. Calvisi

      Article first published online: 19 DEC 2011 | DOI: 10.1002/hep.24736

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      Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis (pages 846–855)

      Toru Takahashi, Tomofumi Miura, Junichiro Nakamura, Satoshi Yamada, Tsutomu Miura, Masahiko Yanagi, Yasunobu Matsuda, Hiroyuki Usuda, Iwao Emura, Koichi Tsuneyama, Xiao-Song He and M. Eric Gershwin

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24757

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  6. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Induced hyperammonemia may compromise the ability to generate restful sleep in patients with cirrhosis (pages 869–878)

      Alessia Bersagliere, Iolanda D. Raduazzo, Mariateresa Nardi, Sami Schiff, Angelo Gatta, Piero Amodio, Peter Achermann and Sara Montagnese

      Article first published online: 19 JAN 2012 | DOI: 10.1002/hep.24741

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      Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells (pages 879–887)

      Virginia Knight, Jorge Tchongue, Dinushka Lourensz, Peter Tipping and William Sievert

      Article first published online: 12 JAN 2012 | DOI: 10.1002/hep.24784

  7. Liver Injury/Regeneration

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Receptor activator of nuclear factor-κB ligand (RANKL) protects against hepatic ischemia/reperfusion injury in mice (pages 888–897)

      Nozomu Sakai, Heather L. Van Sweringen, Rebecca Schuster, John Blanchard, Justin M. Burns, Amit D. Tevar, Michael J. Edwards and Alex B. Lentsch

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24756

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      Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice (pages 898–909)

      Felix Heymann, Linda Hammerich, Dunja Storch, Matthias Bartneck, Sebastian Huss, Vanessa Rüsseler, Nikolaus Gassler, Sergio A. Lira, Tom Luedde, Christian Trautwein and Frank Tacke

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24764

  8. Liver Biology/Pathobiology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells (pages 910–920)

      Chen-Hsin Liao, Chau-Ting Yeh, Ya-Hui Huang, Sheng-Ming Wu, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin, Cheng-Yi Chen, I-Hsiao Chung, Wan-Li Cheng, Wei-Jan Chen and Kwang-Huei Lin

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24740

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      Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers (pages 921–930)

      Lucia Russo, Jorge Gracia-Sancho, Héctor García-Calderó, Giusi Marrone, Juan Carlos García-Pagán, Guillermo García-Cardeña and Jaime Bosch

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24755

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      β-Catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice (pages 931–940)

      Shiguang Liu, Tzu-Hsuan Yeh, Vijay P. Singh, Sruti Shiva, Lindsay Krauland, Huanan Li, Pili Zhang, Kusum Kharbanda, Vladimir Ritov, Satdarshan P.S. Monga, Donald K. Scott, Patricia K. Eagon and Jaideep Behari

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.24766

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      Growth-hormone–induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer (pages 941–952)

      Katrin Friedbichler, Madeleine Themanns, Kristina M. Mueller, Michaela Schlederer, Jan-Wilhelm Kornfeld, Luigi M. Terracciano, Andrey V. Kozlov, Susanne Haindl, Lukas Kenner, Thomas Kolbe, Mathias Mueller, Kenneth J. Snibson, Markus H. Heim and Richard Moriggl

      Article first published online: 13 JAN 2012 | DOI: 10.1002/hep.24765

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  9. AASLD Position Paper

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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  10. Hepatology Elsewhere

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Mice with artificial human liver (pages 974–977)

      Akihide Kamiya and Atsushi Miyajima

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25503

  11. Clinical Observations in Hepatology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
    1. You have free access to this content
  12. Correspondence

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
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      Rapid virological response: Is it four or eight weeks? (page 979)

      Laura Milazzo, Antonella Foschi and Spinello Antinori

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25527

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      Reply (pages 980–981)

      Marc G. Ghany, David R. Nelson, Doris B. Strader, David L. Thomas and Leonard B. Seeff

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25524

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      Reply (pages 981–982)

      Bruno Sangro and for the European Network on Radioembolization With Yttrium-90 Resin Microspheres

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25546

  13. Correction

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
    1. You have free access to this content
      Correction (page 983)

      Article first published online: 23 FEB 2012 | DOI: 10.1002/hep.25622

      This article corrects:
  14. Editorial

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. AASLD Position Paper
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Correction
    15. Editorial
    1. You have free access to this content

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