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Hepatology

Cover image for Vol. 55 Issue 4

April 2012

Volume 55, Issue 4

Pages 985–1311

  1. Editorials

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Attention: Minimal hepatic encephalopathy and road accidents (pages 985–987)

      Piero Amodio, Sara Montagnese and Carlo Merkel

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25583

  2. Viral Hepatitis

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      The global burden of hepatitis E virus genotypes 1 and 2 in 2005 (pages 988–997)

      David B. Rein, Gretchen A. Stevens, Jordan Theaker, John S. Wittenborn and Steven T. Wiersma

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25505

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      Role of low-density lipoprotein receptor in the hepatitis C virus life cycle (pages 998–1007)

      Anna Albecka, Sandrine Belouzard, Anne Op de Beeck, Véronique Descamps, Lucie Goueslain, Justine Bertrand-Michel, François Tercé, Gilles Duverlie, Yves Rouillé and Jean Dubuisson

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25501

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      Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans (pages 1008–1018)

      Lyna Zhang, Ajay Yesupriya, Dale J. Hu, Man-huei Chang, Nicole F. Dowling, Renée M. Ned, Venkatachalam Udhayakumar, Mary Lou Lindegren and Yury Khudyakov

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25513

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      Quantitative liver function tests improve the prediction of clinical outcomes in chronic hepatitis C: Results from the hepatitis C antiviral long-term treatment against cirrhosis trial (pages 1019–1029)

      Gregory T. Everson, Mitchell L. Shiffman, John C. Hoefs, Timothy R. Morgan, Richard K. Sterling, David A. Wagner, Shannon Lauriski, Teresa M. Curto, Anne Stoddard, Elizabeth C. Wright and the HALT-C Trial Group

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24752

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      Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy (pages 1038–1047)

      Christian M. Lange, Zoltan Kutalik, Kenichi Morikawa, Stéphanie Bibert, Andreas Cerny, Günter Dollenmaier, Jean-François Dufour, Tilman J. Gerlach, Markus H. Heim, Raffaele Malinverni, Beat Müllhaupt, Francesco Negro, Darius Moradpour, Pierre-Yves Bochud and the Swiss Hepatitis C Cohort Study Group

      Article first published online: 9 FEB 2012 | DOI: 10.1002/hep.24787

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      Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection (pages 1058–1069)

      Jason Grebely, Son Truong Pham, Gail V. Matthews, Kathy Petoumenos, Rowena A. Bull, Barbara Yeung, William Rawlinson, John Kaldor, Andrew Lloyd, Margaret Hellard, Gregory J. Dore, Peter A. White and on behalf of the ATAHC Study Group

      Article first published online: 29 FEB 2012 | DOI: 10.1002/hep.24754

  3. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease (pages 1083–1093)

      Lars P. Bechmann, Amalia Gastaldelli, Diana Vetter, Gillian L. Patman, Laura Pascoe, Rebekka A. Hannivoort, Ursula E. Lee, Isabel Fiel, Ursula Muñoz, Demetrio Ciociaro, Young-Min Lee, Emma Buzzigoli, Luca Miele, Kei Y. Hui, Elisabetta Bugianesi, Alastair D. Burt, Christopher P. Day, Andrea Mari, Loranne Agius, Mark Walker, Scott L. Friedman and Helen L. Reeves

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24793

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      Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation (pages 1103–1111)

      Christian L. Roth, Clinton T. Elfers, Dianne P. Figlewicz, Susan J. Melhorn, Gregory J. Morton, Andrew Hoofnagle, Matthew M. Yeh, James E. Nelson and Kris V. Kowdley

      Article first published online: 15 FEB 2012 | DOI: 10.1002/hep.24737

  4. Hepatobiliary Malignancies

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma (pages 1112–1121)

      Nataliya Rohr-Udilova, Wolfgang Sieghart, Robert Eferl, Dagmar Stoiber, Linda Björkhem-Bergman, Lennart C. Eriksson, Klaus Stolze, Hubert Hayden, Bernhard Keppler, Sandra Sagmeister, Bettina Grasl-Kraupp, Rolf Schulte-Hermann and Markus Peck-Radosavljevic

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.24808

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      International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18 (pages 1122–1129)

      Wei-Chu Chie, Jane M. Blazeby, Chin-Fu Hsiao, Herng-Chia Chiu, Ronnie T. Poon, Naoko Mikoshiba, Gillian Al-Kadhimi, Nigel Heaton, Jozer Calara, Peter Collins, Katharine Caddick, Anna Costantini, Valerie Vilgrain, Ludovic Trinquart, Chieh Chiang and On behalf of the EORTC Quality of Life Group

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24798

  5. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells (pages 1130–1138)

      Stephen M. Brindley, Allison M. Lanham, Frederick M. Karrer, Rebecca M. Tucker, Andrew P. Fontenot and Cara L. Mack

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.24807

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      Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology (pages 1139–1145)

      Vered Molho-Pessach, Jonathan J. Rios, Chao Xing, Kenneth D.R. Setchell, Jonathan C. Cohen and Helen H. Hobbs

      Article first published online: 8 FEB 2012 | DOI: 10.1002/hep.24781

  6. Liver Failure/ Cirrhosis /Portal Hypertension

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
    1. You have full text access to this OnlineOpen article
      Quantitative histological-hemodynamic correlations in cirrhosis (pages 1146–1153)

      Supatsri Sethasine, Dhanpat Jain, Roberto J. Groszmann and Guadalupe Garcia-Tsao

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.24805

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      Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense (pages 1154–1163)

      Zora Teltschik, Reiner Wiest, Julia Beisner, Sabine Nuding, Claudia Hofmann, Juergen Schoelmerich, Charles L. Bevins, Eduard F. Stange and Jan Wehkamp

      Article first published online: 15 FEB 2012 | DOI: 10.1002/hep.24789

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  7. Liver Injury/Regeneration

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Hepatocyte growth factor/c-met signaling is required for stem-cell–mediated liver regeneration in mice (pages 1215–1226)

      Tsuyoshi Ishikawa, Valentina M. Factor, Jens U. Marquardt, Chiara Raggi, Daekwan Seo, Mitsuteru Kitade, Elizabeth A. Conner and Snorri S. Thorgeirsson

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.24796

  8. Liver Biology/Pathobiology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
    1. You have full text access to this OnlineOpen article
      Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing (pages 1227–1236)

      Rui M. Tostões, Sofia B. Leite, Margarida Serra, Janne Jensen, Petter Björquist, Manuel J. T. Carrondo, Catarina Brito and Paula M. Alves

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.24760

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      Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation (pages 1237–1248)

      Nieves Embade, David Fernández-Ramos, Marta Varela-Rey, Naiara Beraza, Marcella Sini, Virginia Gutiérrez de Juan, Ashwin Woodhoo, Nuria Martínez-López, Begoña Rodríguez-Iruretagoyena, Francisco Javier Bustamante, Ana Belén de la Hoz, Arkaitz Carracedo, Dimitris P. Xirodimas, Manuel S. Rodríguez, Shelly C. Lu, José M. Mato and María L. Martínez-Chantar

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24795

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      Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeability (pages 1249–1259)

      Brigitte Grosse, Doris Cassio, Nadya Yousef, Céline Bernardo, Emmanuel Jacquemin and Emmanuel Gonzales

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24761

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      Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect (pages 1271–1281)

      Melissa D. Yang, Yi-Ming Chiang, Reiichi Higashiyama, Kinji Asahina, Derek A. Mann, Jelena Mann, Clay C.C. Wang and Hidekazu Tsukamoto

      Article first published online: 1 MAR 2012 | DOI: 10.1002/hep.24792

  9. Reviews

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
    1. You have full text access to this OnlineOpen article
      Adrenocortical dysfunction in liver disease: A systematic review (pages 1282–1291)

      Giuseppe Fede, Luisa Spadaro, Tania Tomaselli, Graziella Privitera, Giacomo Germani, Emmanuel Tsochatzis, Michael Thomas, Pierre-Marc Bouloux, Andrew K. Burroughs and Francesco Purrello

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25573

  10. Hepatology Elsewhere

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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  11. Clinical Perspectives in Hepatology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Balloon-occluded retrograde transvenous obliteration for the treatment of gastric varices (pages 1301–1304)

      Alia S. Dadabhai, Jonathan M. Fenkel, Daniel B. Brown and Loren Laine

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25635

  12. Correspondence

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
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      Sorafenib in clinical practice: Evidence-based use or abuse? (page 1305)

      Michele Basso, Maria Basso and Carlo Barone

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25541

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      Reply: (pages 1305–1306)

      Massimo Iavarone, Giuseppe Cabibbo and Massimo Colombo

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25547

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      Acute liver failure: What is it? (pages 1306–1307)

      Kama A. Wlodzimirow, Saeid Eslami, Ameen Abu-Hanna, Martin Nieuwoudt and Robert A.F.M. Chamuleau

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25519

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      PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis (pages 1307–1308)

      Eric Trepo, Erwan Guyot, Nathalie Ganne-Carrie, Delphine Degre, Thierry Gustot, Denis Franchimont, Angela Sutton, Pierre Nahon and Christophe Moreno

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25518

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      Reply: (pages 1309–1310)

      Robert P. Myers

      Article first published online: 27 MAR 2012 | DOI: 10.1002/hep.25678

  13. Corrections

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
    1. You have free access to this content
  14. Correction

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/ Cirrhosis /Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Perspectives in Hepatology
    13. Correspondence
    14. Corrections
    15. Correction
    1. You have free access to this content
      Correction (page 1311)

      Article first published online: 20 MAR 2012 | DOI: 10.1002/hep.25693

      This article corrects:

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