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Hepatology

Cover image for Vol. 56 Issue 1

July 2012

Volume 56, Issue 1

Pages 1–397, E1–E25

  1. Editorials

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Systems biology methods help develop a better understanding of hepatitis C virus–induced liver injury (pages 1–4)

      Ragunath Singaravelu, Neda Nasheri, Allison Sherratt and John Paul Pezacki

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25727

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  2. Viral Hepatitis

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      Early transcriptional programming links progression to hepatitis C virus–induced severe liver disease in transplant patients (pages 17–27)

      Angela L. Rasmussen, Nicolas Tchitchek, Nathan J. Susnow, Alexei L. Krasnoselsky, Deborah L. Diamond, Matthew M. Yeh, Sean C. Proll, Marcus J. Korth, Kathie-Anne Walters, Sharon Lederer, Anne M. Larson, Robert L. Carithers, Arndt Benecke and Michael G. Katze

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25612

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      Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus–mediated liver disease posttransplantation (pages 28–38)

      Deborah L. Diamond, Alexei L. Krasnoselsky, Kristin E. Burnum, Matthew E. Monroe, Bobbie-Jo Webb-Robertson, Jason E. McDermott, Matthew M. Yeh, Jose Felipe Golib Dzib, Nathan Susnow, Susan Strom, Sean C. Proll, Sarah E. Belisle, David E. Purdy, Angela L. Rasmussen, Kathie-Anne Walters, Jon M. Jacobs, Marina A. Gritsenko, David G. Camp, Renuka Bhattacharya, James D. Perkins, Robert L. Carithers Jr., Iris W. Liou, Anne M. Larson, Arndt Benecke, Katrina M. Waters, Richard D. Smith and Michael G. Katze

      Article first published online: 24 APR 2012 | DOI: 10.1002/hep.25649

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      High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients (pages 39–48)

      Caroline Scholtes, Christophe Ramière, Dominique Rainteau, Laure Perrin-Cocon, Claude Wolf, Lydie Humbert, Martine Carreras, Aurélie Guironnet-Paquet, Fabien Zoulim, Ralf Bartenschlager, Vincent Lotteau, Patrice André and Olivier Diaz

      Article first published online: 25 APR 2012 | DOI: 10.1002/hep.25628

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      Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner (pages 49–56)

      Paul J. Clark, Alexander J. Thompson, David M. Vock, Lisa E. Kratz, Adviye A. Tolun, Andrew J. Muir, John G. McHutchison, Mani Subramanian, David M. Millington, Richard I. Kelley and Keyur Patel

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25631

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      Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B (pages 67–75)

      Milan J. Sonneveld, Vincent Rijckborst, Stefan Zeuzem, E. Jenny Heathcote, Krzysztof Simon, Hakan Senturk, Suzan D. Pas, Bettina E. Hansen and Harry L.A. Janssen

      Article first published online: 25 APR 2012 | DOI: 10.1002/hep.25636

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      Hepatitis delta virus infects the cells of hepadnavirus-induced hepatocellular carcinoma in woodchucks (pages 76–85)

      Natalia Freitas, Jessica Salisse, Celso Cunha, Ilia Toshkov, Stephan Menne and Severin O. Gudima

      Article first published online: 25 APR 2012 | DOI: 10.1002/hep.25663

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      HCV RNA levels in a multiethnic cohort of injection drug users: Human genetic, viral and demographic associations (pages 86–94)

      Lorenzo Uccellini, Fan-Chen Tseng, Alessandro Monaco, Fatma M. Shebl, Ruth Pfeiffer, Myhanh Dotrang, Dianna Buckett, Michael P. Busch, Ena Wang, Brian R. Edlin, Francesco M. Marincola and Thomas R. O'Brien

      Article first published online: 1 JUN 2012 | DOI: 10.1002/hep.25652

  3. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Cidea promotes hepatic steatosis by sensing dietary fatty acids (pages 95–107)

      Linkang Zhou, Li Xu, Jing Ye, De Li, Wenshan Wang, Xuanhe Li, Lizhen Wu, Hui Wang, Feifei Guan and Peng Li

      Article first published online: 1 JUN 2012 | DOI: 10.1002/hep.25611

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      Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice (pages 108–117)

      Jiyoung Lee, Sunmi Seok, Pengfei Yu, Kyungsu Kim, Zachary Smith, Marcelo Rivas-Astroza, Sheng Zhong and Jongsook Kim Kemper

      Article first published online: 24 APR 2012 | DOI: 10.1002/hep.25609

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      Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis (pages 118–129)

      Naoki Tanaka, Tsutomu Matsubara, Kristopher W. Krausz, Andrew D. Patterson and Frank J. Gonzalez

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25630

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      Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice (pages 130–139)

      Masato Tsuchiya, Cheng Ji, Oksana Kosyk, Svitlana Shymonyak, Stepan Melnyk, Hiroshi Kono, Volodymyr Tryndyak, Levan Muskhelishvili, Igor P. Pogribny, Neil Kaplowitz and Ivan Rusyn

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25641

  4. Hepatobiliary Malignancies

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Hepatocellular carcinoma: Detection with diffusion-weighted versus contrast-enhanced magnetic resonance imaging in pretransplant patients (pages 140–148)

      Mi-Suk Park, Sooah Kim, Jignesh Patel, Cristina H. Hajdu, Richard K. G. Do, Lorenzo Mannelli, James S. Babb and Bachir Taouli

      Article first published online: 18 JUN 2012 | DOI: 10.1002/hep.25681

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      A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list (pages 149–156)

      Christian Toso, Elise Dupuis-Lozeron, Pietro Majno, Thierry Berney, Norman M. Kneteman, Thomas Perneger, Philippe Morel, Gilles Mentha and Christophe Combescure

      Article first published online: 18 JUN 2012 | DOI: 10.1002/hep.25603

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      Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 reaction in cancer tissue (pages 157–164)

      Kenichi Harada, Shinji Shimoda, Yasushi Kimura, Yasunori Sato, Hiroko Ikeda, Saya Igarashi, Xiang-Shan Ren, Hirohide Sato and Yasuni Nakanuma

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25627

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      Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression (pages 165–175)

      Maddalena Frau, Maria L. Tomasi, Maria M. Simile, Maria I. Demartis, Fabiana Salis, Gavinella Latte, Diego F. Calvisi, Maria A. Seddaiu, Lucia Daino, Claudio F. Feo, Stefania Brozzetti, Giuliana Solinas, Satoshi Yamashita, Toshikazu Ushijima, Francesco Feo and Rosa M. Pascale

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25643

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      Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis (pages 176–185)

      Wen-Lung Ma, Cheng-Lung Hsu, Chun-Chieh Yeh, Ming-Heng Wu, Chiung-Kuei Huang, Long-Bin Jeng, Yao-Ching Hung, Tze-Yi Lin, Shuyuan Yeh and Chawnshang Chang

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25644

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  5. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis (pages 198–208)

      Christophe Corpechot, Fabrice Carrat, Armelle Poujol-Robert, Farid Gaouar, Dominique Wendum, Olivier Chazouillères and Raoul Poupon

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25599

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      Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation (pages 209–218)

      Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf and Pierre-Alain Clavien

      Article first published online: 5 JUN 2012 | DOI: 10.1002/hep.25626

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  6. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Liver stiffness predicts clinical outcome in human immunodeficiency virus/hepatitis C virus-coinfected patients with compensated liver cirrhosis (pages 228–238)

      Nicolás Merchante, Antonio Rivero-Juárez, Francisco Téllez, Dolores Merino, Maria José Ríos-Villegas, Manuel Márquez-Solero, Mohamed Omar, Juan Macías, Ángela Camacho, Montserrat Pérez-Pérez, Jesús Gómez-Mateos, Antonio Rivero, Juan Antonio Pineda and on behalf of the Grupo Andaluz para el Estudio de las Hepatitis Víricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI)

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25616

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      Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats (pages 248–258)

      Hui-Chun Huang, Sun-Sang Wang, I-Fang Hsin, Ching-Chih Chang, Fa-Yauh Lee, Han-Chieh Lin, Chiao-Lin Chuang, Jing-Yi Lee, Hsian-Guey Hsieh and Shou-Dong Lee

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25625

  7. Liver Injury/Regeneration

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation (pages 259–269)

      Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25607

    2. You have full text access to this OnlineOpen article
      Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice (pages 270–280)

      Claudia D. Fuchs, Thierry Claudel, Pooja Kumari, Guenter Haemmerle, Marion J. Pollheimer, Tatjana Stojakovic, Hubert Scharnagl, Emina Halilbasic, Judith Gumhold, Dagmar Silbert, Harald Koefeler and Michael Trauner

      Article first published online: 29 MAY 2012 | DOI: 10.1002/hep.25601

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  8. Liver Biology/Pathobiology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Inhibition of hepcidin transcription by growth factors (pages 291–299)

      Julia B. Goodnough, Emilio Ramos, Elizabeta Nemeth and Tomas Ganz

      Article first published online: 18 JUN 2012 | DOI: 10.1002/hep.25615

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      Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis (pages 300–310)

      Ashley M. Lakner, Nury M. Steuerwald, Tracy L. Walling, Sriparna Ghosh, Ting Li, Iain H. McKillop, Mark W. Russo, Herbert L. Bonkovsky and Laura W. Schrum

      Article first published online: 18 JUN 2012 | DOI: 10.1002/hep.25613

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      Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria (pages 322–331)

      Amika Singla, David S. Moons, Natasha T. Snider, Elizabeth R. Wagenmaker, V. Bernadene Jayasundera and M. Bishr Omary

      Article first published online: 25 APR 2012 | DOI: 10.1002/hep.25664

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      Comparative proteomic analysis of rat hepatic stellate cell activation: A comprehensive view and suppressed immune response (pages 332–349)

      Juling Ji, Feng Yu, Qiuhong Ji, Zhiyao Li, Kuidong Wang, Jinsheng Zhang, Jinbiao Lu, Li Chen, Qun E, Yaoying Zeng and Yuhua Ji

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25650

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  9. Reviews

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Introduction to the genetics and biology of interleukin-28B (pages 361–366)

      Thomas Urban, Michael R. Charlton and David B. Goldstein

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25794

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  10. Hepatology Elsewhere

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
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    3. You have full text access to this OnlineOpen article
      When activated oncogene meets immunity: A fight to prevent liver tumor initiation (pages 387–389)

      Jean-Charles Nault, Giuliana Amaddeo and Jessica Zucman-Rossi

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25733

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  11. Clinical Observations in Hepatology

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
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  12. Correspondence

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article
      Association between interleukin-28B-related genetic variants and liver histopathology differs between hepatitis C virus genotypes (page 394)

      Karolina Rembeck, Johan Westin, Magnus Lindh, Kristoffer Hellstrand, Gunnar Norkrans, Martin Laging and For the NORDynamIC study group

      Article first published online: 6 JUN 2012 | DOI: 10.1002/hep.25598

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      Gall bladder polyps in primary sclerosing cholangitis: Adhere to the guidelines (page 396)

      Gregory Gores, Keith D. Lindor and Nataliya Razumilava

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25585

  13. Corrections

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have free access to this content
      Corrections (page 397)

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25835

      This article corrects:

      The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis1

      Vol. 55, Issue 5, 1529–1539, Article first published online: 4 APR 2012

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      Corrections (page 397)

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25836

      This article corrects:
    3. You have free access to this content
  14. Special Article

    1. Top of page
    2. Editorials
    3. Viral Hepatitis
    4. Steatohepatitis/Metabolic Liver Disease
    5. Hepatobiliary Malignancies
    6. Autoimmune, Cholestatic and Biliary Disease
    7. Liver Failure/Cirrhosis/Portal Hypertension
    8. Liver Injury/Regeneration
    9. Liver Biology/Pathobiology
    10. Reviews
    11. Hepatology Elsewhere
    12. Clinical Observations in Hepatology
    13. Correspondence
    14. Corrections
    15. Special Article
    1. You have full text access to this OnlineOpen article

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