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Hepatology

Cover image for Vol. 56 Issue 2

August 2012

Volume 56, Issue 2

Pages 399–791

  1. Master's Perspective

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
  2. Editorials

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
    3. You have full text access to this OnlineOpen article
  3. Viral Hepatitis

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels (pages 434–443)

      Teresa Pollicino, Giuliana Amaddeo, Agnese Restuccia, Giuseppina Raffa, Angela Alibrandi, Giuseppina Cutroneo, Angelo Favaloro, Sergio Maimone, Giovanni Squadrito and Giovanni Raimondo

      Article first published online: 13 JUL 2012 | DOI: 10.1002/hep.25592

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      Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response (pages 444–454)

      Susanna Naggie, Anu Osinusi, Antonios Katsounas, Richard Lempicki, Eva Herrmann, Alexander J. Thompson, Paul J. Clark, Keyur Patel, Andrew J. Muir, John G. McHutchison, Joerg F. Schlaak, Martin Trippler, Bhavana Shivakumar, Henry Masur, Michael A. Polis and Shyam Kottilil

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25647

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      Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin (pages 464–473)

      Stephen A. Harrison, Fayez M. Hamzeh, Jian Han, Prashant K. Pandya, Muhammed Y. Sheikh and John M. Vierling

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25661

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      Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B (pages 474–483)

      Itziar Otano, Lester Suarez, Javier Dotor, Manuela Gonzalez-Aparicio, Julien Crettaz, Cristina Olagüe, Africal Vales, Jose Ignacio Riezu, Esther Larrea, Francisco Borras, Alberto Benito, Ruben Hernandez-Alcoceba, Stephan Menne, Jesús Prieto and Gloria González-Aseguinolaza

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25667

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      Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding (pages 484–491)

      Shufeng Liu, Kevin D. McCormick, Wentao Zhao, Ting Zhao, Daping Fan and Tianyi Wang

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25665

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      Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C (pages 492–500)

      John D. Ryan, Sandro Altamura, Emma Devitt, Sarah Mullins, Matthew W. Lawless, Martina U. Muckenthaler and John Crowe

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25666

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      A human claudin-1–derived peptide inhibits hepatitis C virus entry (pages 507–515)

      Youhui Si, Shufeng Liu, Xiuying Liu, Jana L. Jacobs, Min Cheng, Yuqiang Niu, Qi Jin, Tianyi Wang and Wei Yang

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25685

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      Persistence of hepatitis A vaccine induced seropositivity in infants and young children by maternal antibody status: 10-year follow-up (pages 516–522)

      Umid M. Sharapov, Lisa R. Bulkow, Susan E. Negus, Philip R. Spradling, Chriss Homan, Jan Drobeniuc, Michael Bruce, Saleem Kamili, Dale J. Hu and Brian J. McMahon

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25687

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      Pegylated interferon for chronic hepatitis C in children affects growth and body composition: Results from the pediatric study of hepatitis C (PEDS-C) trial (pages 523–531)

      Maureen M. Jonas, William Balistreri, Regino P. Gonzalez-Peralta, Barbara Haber, Steven Lobritto, Parvathi Mohan, Jean P. Molleston, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Kathleen B. Schwarz, Bruce A. Barton, John A. Shepherd, Paul D. Mitchell and Christopher Duggan

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25690

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      A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis (pages 532–543)

      Roberta D'Ambrosio, Alessio Aghemo, Maria Grazia Rumi, Guido Ronchi, Maria Francesca Donato, Valerie Paradis, Massimo Colombo and Pierre Bedossa

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25606

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      Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users (pages 544–554)

      Supriya Munshaw, Hyon S. Hwang, Michael Torbenson, Jeffrey Quinn, Kasper D. Hansen, Jacquie Astemborski, Shruti H. Mehta, Stuart C. Ray, David L. Thomas and Ashwin Balagopal

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25655

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      Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse (pages 555–566)

      Akihito Okazaki, Nobuhiko Hiraga, Michio Imamura, C. Nelson Hayes, Masataka Tsuge, Shoichi Takahashi, Hiroshi Aikata, Hiromi Abe, Daiki Miki, Hidenori Ochi, Chise Tateno, Katsutoshi Yoshizato, Hideki Ohdan and Kazuaki Chayama

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25651

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      Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin (pages 567–575)

      Ira M. Jacobson, Patrick Marcellin, Stefan Zeuzem, Mark S. Sulkowski, Rafael Esteban, Fred Poordad, Savino Bruno, Margaret H. Burroughs, Lisa D. Pedicone, Navdeep Boparai, Weiping Deng, Mark J. DiNubile, Keith M. Gottesdiener, Clifford A. Brass, Janice K. Albrecht and Jean-Pierre Bronowicki

      Article first published online: 29 JUN 2012 | DOI: 10.1002/hep.25865

  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
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      Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice (pages 585–593)

      Roheeth D. Delima, Anita C.G. Chua, Janina E.E. Tirnitz-Parker, Eng K. Gan, Kevin D. Croft, Ross M. Graham, John K. Olynyk and Debbie Trinder

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25689

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      Nonalcoholic fatty liver disease is associated with coronary artery calcification (pages 605–613)

      Donghee Kim, Su-Yeon Choi, Eun Ha Park, Whal Lee, Jin Hwa Kang, Won Kim, Yoon Jun Kim, Jung-Hwan Yoon, Sook Hyang Jeong, Dong Ho Lee, Hyo-suk Lee, Joseph Larson, Terry M. Therneau and W. Ray Kim

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25593

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
      Model to estimate survival in ambulatory patients with hepatocellular carcinoma (pages 614–621)

      Ju Dong Yang, W. Ray Kim, Kyung Woo Park, Roongruedee Chaiteerakij, Bohyun Kim, Schuyler O. Sanderson, Joseph J. Larson, Rachel A. Pedersen, Terry M. Therneau, Gregory J. Gores, Lewis R. Roberts and Joong-Won Park

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25680

    2. You have full text access to this OnlineOpen article
      Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis (pages 622–631)

      Sandy Leung-Kuen Au, Carmen Chak-Lui Wong, Joyce Man-Fong Lee, Dorothy Ngo-Yin Fan, Felice Hoching Tsang, Irene Oi-Lin Ng and Chun-Ming Wong

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25679

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      Androgen pathway stimulates MicroRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis (pages 632–643)

      Po-Jen Chen, Shiou-Hwei Yeh, Wan-Hsin Liu, Chen-Ching Lin, Hsuan-Cheng Huang, Chi-Ling Chen, Ding-Shinn Chen and Pei-Jer Chen

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25695

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      Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer (pages 644–657)

      Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Young Gyoon Chang, Min Gyu Kim, Won Sang Park, Jung Young Lee, Sang-Yeop Lee, In-Sun Chu and Suk Woo Nam

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25699

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      Long-term outcome of Japanese patients with type 1 autoimmune hepatitis (pages 668–676)

      Kaname Yoshizawa, Akihiro Matsumoto, Tetsuya Ichijo, Takeji Umemura, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Eiji Tanaka, Masao Ota, Yoshihiko Katsuyama, Kendo Kiyosawa, Masanori Abe and Morikazu Onji

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25658

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      The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway (pages 677–686)

      Rodrigo Liberal, Charlotte R. Grant, Beth S. Holder, Yun Ma, Giorgina Mieli-Vergani, Diego Vergani and Maria Serena Longhi

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25682

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      Up-regulation of microRNA 506 leads to decreased Cl/HCO3 anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis (pages 687–697)

      Jesús M. Banales, Elena Sáez, Miriam Úriz, Sarai Sarvide, Aura D. Urribarri, Patrick Splinter, Pamela S. Tietz Bogert, Luis Bujanda, Jesús Prieto, Juan F. Medina and Nicholas F. LaRusso

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25691

  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      Long-term follow-up of hemodynamic responders to pharmacological therapy after variceal bleeding (pages 706–714)

      Salvador Augustin, Antonio González, Laia Badia, Laura Millán, Aranzazu Gelabert, Alejandro Romero, Antoni Segarra, María Martell, Rafael Esteban, Jaime Guardia and Joan Genescà

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25686

  8. Liver Injury/Regeneration

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
      TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure (pages 715–726)

      Junfeng An, Christoph Harms, Gisela Lättig-Tünnemann, Gernot Sellge, Ana D. Mandić, Yann Malato, Arnd Heuser, Matthias Endres, Christian Trautwein and Stefan Donath

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25697

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      Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans (pages 735–746)

      Charalambos Gustav Antoniades, Alberto Quaglia, Leonie S. Taams, Ragai R. Mitry, Munther Hussain, Robin Abeles, Lucia A. Possamai, Matthew Bruce, Mark McPhail, Christopher Starling, Bart Wagner, Adrian Barnardo, Sabine Pomplun, Georg Auzinger, William Bernal, Nigel Heaton, Diego Vergani, Mark R. Thursz and Julia Wendon

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25657

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      Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase (pages 747–759)

      Laura Gomez-Santos, Zigmund Luka, Conrad Wagner, Sara Fernandez-Alvarez, Shelly C. Lu, Jose M. Mato, Maria L. Martinez-Chantar and Naiara Beraza

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25694

  9. Liver Biology/Pathobiology

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
  10. New Horizons

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
  11. Hepatology Elsewhere

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
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      Closing the gap on drug-induced liver injury (pages 781–783)

      Marion Maurel and Jean Rosenbaum

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25779

  12. Clinical Observations in Hepatology

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
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  13. Correspondence

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
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      Correspondence (page 787)

      Korosh Khalili and Morris Sherman

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25633

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      Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinoma (pages 789–790)

      Dominik Bettinger, Michael Schultheiβ, Eva Knüppel, Robert Thimme, Hubert E. Blum and Hans Christian Spangenberg

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25637

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