Hepatology

Copyright © 2013 American Association for the Study of Liver Diseases

Cover image for Vol. 56 Issue 2

August 2012

Volume 56, Issue 2

Pages 399–791

  1. Master's Perspective

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Clinical trials and their translation in hepatology: Past, present, and future (pages 399–410)

      E. Jenny Heathcote

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25557

  2. Editorials

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Hepatitis B surface antigen quantification: Not what it seems on the surface (pages 411–414)

      Stephen Locarnini and Scott Bowden

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25732

    2. Plasma phospholipid transfer protein: A multifaceted protein with a key role in the assembly and secretion of apolipoprotein B–containing lipoproteins by the liver (pages 415–418)

      Laurent Lagrost

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25725

    3. Hepatitis B in the United States: A major health disparity affecting many foreign-born populations (pages 419–421)

      John W. Ward and Kathy K. Byrd

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25799

  3. Viral Hepatitis

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin (pages 422–433)

      Kris V. Kowdley, Chia C. Wang, Sue Welch, Henry Roberts and Carol L. Brosgart

      Article first published online: 16 FEB 2012 | DOI: 10.1002/hep.24804

    2. Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels (pages 434–443)

      Teresa Pollicino, Giuliana Amaddeo, Agnese Restuccia, Giuseppina Raffa, Angela Alibrandi, Giuseppina Cutroneo, Angelo Favaloro, Sergio Maimone, Giovanni Squadrito and Giovanni Raimondo

      Article first published online: 13 JUL 2012 | DOI: 10.1002/hep.25592

    3. Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response (pages 444–454)

      Susanna Naggie, Anu Osinusi, Antonios Katsounas, Richard Lempicki, Eva Herrmann, Alexander J. Thompson, Paul J. Clark, Keyur Patel, Andrew J. Muir, John G. McHutchison, Joerg F. Schlaak, Martin Trippler, Bhavana Shivakumar, Henry Masur, Michael A. Polis and Shyam Kottilil

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25647

    4. Pegylated interferon-associated retinopathy is frequent in hepatitis C virus patients with hypertension and justifies ophthalmologic screening (pages 455–463)

      Stela Vujosevic, Diego Tempesta, Franco Noventa, Edoardo Midena and Giada Sebastiani

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25654

    5. Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin (pages 464–473)

      Stephen A. Harrison, Fayez M. Hamzeh, Jian Han, Prashant K. Pandya, Muhammed Y. Sheikh and John M. Vierling

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25661

    6. Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B (pages 474–483)

      Itziar Otano, Lester Suarez, Javier Dotor, Manuela Gonzalez-Aparicio, Julien Crettaz, Cristina Olagüe, Africal Vales, Jose Ignacio Riezu, Esther Larrea, Francisco Borras, Alberto Benito, Ruben Hernandez-Alcoceba, Stephan Menne, Jesús Prieto and Gloria González-Aseguinolaza

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25667

    7. Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding (pages 484–491)

      Shufeng Liu, Kevin D. McCormick, Wentao Zhao, Ting Zhao, Daping Fan and Tianyi Wang

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25665

    8. Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C (pages 492–500)

      John D. Ryan, Sandro Altamura, Emma Devitt, Sarah Mullins, Matthew W. Lawless, Martina U. Muckenthaler and John Crowe

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25666

    9. Hepatitis A virus vaccination in persons with hepatitis C virus infection: Consequences of quality measure implementation (pages 501–506)

      Ian A. Rowe, Richard Parker, Matthew J. Armstrong, Diarmaid D. Houlihan and David J. Mutimer

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25683

    10. A human claudin-1–derived peptide inhibits hepatitis C virus entry (pages 507–515)

      Youhui Si, Shufeng Liu, Xiuying Liu, Jana L. Jacobs, Min Cheng, Yuqiang Niu, Qi Jin, Tianyi Wang and Wei Yang

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25685

    11. Persistence of hepatitis A vaccine induced seropositivity in infants and young children by maternal antibody status: 10-year follow-up (pages 516–522)

      Umid M. Sharapov, Lisa R. Bulkow, Susan E. Negus, Philip R. Spradling, Chriss Homan, Jan Drobeniuc, Michael Bruce, Saleem Kamili, Dale J. Hu and Brian J. McMahon

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25687

    12. Pegylated interferon for chronic hepatitis C in children affects growth and body composition: Results from the pediatric study of hepatitis C (PEDS-C) trial (pages 523–531)

      Maureen M. Jonas, William Balistreri, Regino P. Gonzalez-Peralta, Barbara Haber, Steven Lobritto, Parvathi Mohan, Jean P. Molleston, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Kathleen B. Schwarz, Bruce A. Barton, John A. Shepherd, Paul D. Mitchell and Christopher Duggan

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25690

    13. A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis (pages 532–543)

      Roberta D'Ambrosio, Alessio Aghemo, Maria Grazia Rumi, Guido Ronchi, Maria Francesca Donato, Valerie Paradis, Massimo Colombo and Pierre Bedossa

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25606

    14. Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users (pages 544–554)

      Supriya Munshaw, Hyon S. Hwang, Michael Torbenson, Jeffrey Quinn, Kasper D. Hansen, Jacquie Astemborski, Shruti H. Mehta, Stuart C. Ray, David L. Thomas and Ashwin Balagopal

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25655

    15. Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse (pages 555–566)

      Akihito Okazaki, Nobuhiko Hiraga, Michio Imamura, C. Nelson Hayes, Masataka Tsuge, Shoichi Takahashi, Hiroshi Aikata, Hiromi Abe, Daiki Miki, Hidenori Ochi, Chise Tateno, Katsutoshi Yoshizato, Hideki Ohdan and Kazuaki Chayama

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25651

    16. Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin (pages 567–575)

      Ira M. Jacobson, Patrick Marcellin, Stefan Zeuzem, Mark S. Sulkowski, Rafael Esteban, Fred Poordad, Savino Bruno, Margaret H. Burroughs, Lisa D. Pedicone, Navdeep Boparai, Weiping Deng, Mark J. DiNubile, Keith M. Gottesdiener, Clifford A. Brass, Janice K. Albrecht and Jean-Pierre Bronowicki

      Article first published online: 29 JUN 2012 | DOI: 10.1002/hep.25865

  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice (pages 576–584)

      Amirfarbod Yazdanyar and Xian-Cheng Jiang

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25648

    2. Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice (pages 585–593)

      Roheeth D. Delima, Anita C.G. Chua, Janina E.E. Tirnitz-Parker, Eng K. Gan, Kevin D. Croft, Ross M. Graham, John K. Olynyk and Debbie Trinder

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25689

    3. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes (pages 594–604)

      Eddy Kao, Masao Shinohara, Min Feng, Mo Yin Lau and Cheng Ji

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25702

    4. Nonalcoholic fatty liver disease is associated with coronary artery calcification (pages 605–613)

      Donghee Kim, Su-Yeon Choi, Eun Ha Park, Whal Lee, Jin Hwa Kang, Won Kim, Yoon Jun Kim, Jung-Hwan Yoon, Sook Hyang Jeong, Dong Ho Lee, Hyo-suk Lee, Joseph Larson, Terry M. Therneau and W. Ray Kim

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25593

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Model to estimate survival in ambulatory patients with hepatocellular carcinoma (pages 614–621)

      Ju Dong Yang, W. Ray Kim, Kyung Woo Park, Roongruedee Chaiteerakij, Bohyun Kim, Schuyler O. Sanderson, Joseph J. Larson, Rachel A. Pedersen, Terry M. Therneau, Gregory J. Gores, Lewis R. Roberts and Joong-Won Park

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25680

    2. Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis (pages 622–631)

      Sandy Leung-Kuen Au, Carmen Chak-Lui Wong, Joyce Man-Fong Lee, Dorothy Ngo-Yin Fan, Felice Hoching Tsang, Irene Oi-Lin Ng and Chun-Ming Wong

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25679

    3. Androgen pathway stimulates MicroRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis (pages 632–643)

      Po-Jen Chen, Shiou-Hwei Yeh, Wan-Hsin Liu, Chen-Ching Lin, Hsuan-Cheng Huang, Chi-Ling Chen, Ding-Shinn Chen and Pei-Jer Chen

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25695

    4. Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer (pages 644–657)

      Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Young Gyoon Chang, Min Gyu Kim, Won Sang Park, Jung Young Lee, Sang-Yeop Lee, In-Sun Chu and Suk Woo Nam

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25699

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have full text access to this OnlineOpen article
      Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice (pages 658–667)

      Shujuan Chen, Mei-Fei Yueh, Ronald M. Evans and Robert H. Tukey

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25671

    2. Long-term outcome of Japanese patients with type 1 autoimmune hepatitis (pages 668–676)

      Kaname Yoshizawa, Akihiro Matsumoto, Tetsuya Ichijo, Takeji Umemura, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Eiji Tanaka, Masao Ota, Yoshihiko Katsuyama, Kendo Kiyosawa, Masanori Abe and Morikazu Onji

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25658

    3. The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway (pages 677–686)

      Rodrigo Liberal, Charlotte R. Grant, Beth S. Holder, Yun Ma, Giorgina Mieli-Vergani, Diego Vergani and Maria Serena Longhi

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25682

    4. Up-regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis (pages 687–697)

      Jesús M. Banales, Elena Sáez, Miriam Úriz, Sarai Sarvide, Aura D. Urribarri, Patrick Splinter, Pamela S. Tietz Bogert, Luis Bujanda, Jesús Prieto, Juan F. Medina and Nicholas F. LaRusso

      Article first published online: 10 JUL 2012 | DOI: 10.1002/hep.25691

  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: A 10-year nationwide cohort study (pages 698–705)

      Yao-Chun Hsu, Jaw-Town Lin, Tzu-Ting Chen, Ming-Shiang Wu and Chun-Ying Wu

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25684

    2. Long-term follow-up of hemodynamic responders to pharmacological therapy after variceal bleeding (pages 706–714)

      Salvador Augustin, Antonio González, Laia Badia, Laura Millán, Aranzazu Gelabert, Alejandro Romero, Antoni Segarra, María Martell, Rafael Esteban, Jaime Guardia and Joan Genescà

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25686

  8. Liver Injury/Regeneration

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure (pages 715–726)

      Junfeng An, Christoph Harms, Gisela Lättig-Tünnemann, Gernot Sellge, Ana D. Mandić, Yann Malato, Arnd Heuser, Matthias Endres, Christian Trautwein and Stefan Donath

      Article first published online: 3 JUL 2012 | DOI: 10.1002/hep.25697

    2. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death (pages 727–734)

      Christopher H. Remien, Frederick R. Adler, Lindsey Waddoups, Terry D. Box and Norman L. Sussman

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25656

    3. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans (pages 735–746)

      Charalambos Gustav Antoniades, Alberto Quaglia, Leonie S. Taams, Ragai R. Mitry, Munther Hussain, Robin Abeles, Lucia A. Possamai, Matthew Bruce, Mark McPhail, Christopher Starling, Bart Wagner, Adrian Barnardo, Sabine Pomplun, Georg Auzinger, William Bernal, Nigel Heaton, Diego Vergani, Mark R. Thursz and Julia Wendon

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25657

    4. Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase (pages 747–759)

      Laura Gomez-Santos, Zigmund Luka, Conrad Wagner, Sara Fernandez-Alvarez, Shelly C. Lu, Jose M. Mato, Maria L. Martinez-Chantar and Naiara Beraza

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25694

  9. Liver Biology/Pathobiology

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Hepatocyte senescence in vivo following preconditioning for liver repopulation (pages 760–768)

      Maria Paola Serra, Fabio Marongiu, Marcella Sini and Ezio Laconi

      Article first published online: 11 JUN 2012 | DOI: 10.1002/hep.25698

  10. New Horizons

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. Fibrosis-dependent mechanisms of hepatocarcinogenesis (pages 769–775)

      David Y. Zhang and Scott L. Friedman

      Article first published online: 29 JUN 2012 | DOI: 10.1002/hep.25670

  11. Hepatology Elsewhere

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. The patient, the doctor, and the system: Underdiagnosis and undertreatment of hepatitis B (pages 776–777)

      Tram T. Tran and Luis H. Ocampo Jr

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25774

    2. Exploring beyond cirrhosis (pages 778–780)

      Massimo Pinzani

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25775

    3. Closing the gap on drug-induced liver injury (pages 781–783)

      Marion Maurel and Jean Rosenbaum

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25779

  12. Clinical Observations in Hepatology

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. You have free access to this content
      Right diaphragmatic defect in hepatic hydrothorax exposed by contrast-enhanced ultrasonography after radiofrequency ablation (pages 784–785)

      Tomomitsu Matono, Masahiko Koda and Yoshikazu Murawaki

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25860

  13. Correspondence

    1. Top of page
    2. Master's Perspective
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. New Horizons
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    1. The role of imaging techniques in clinical decision making for the management of hepatocellular carcinoma (page 786)

      Gin-Ho Lo

      Article first published online: 2 JUL 2012 | DOI: 10.1002/hep.25618

    2. Early diagnosis of hepatocellular carcinoma: It's not a matter of opinion (page 787)

      Eugenio Caturelli and Giorgia Ghittoni

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25640

    3. Correspondence (page 787)

      Korosh Khalili and Morris Sherman

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25633

    4. Diagnostic accuracy of adipose insulin resistance index and visceral adiposity index for progressive liver histology and cardiovascular risk in nonalcoholic fatty liver disease (pages 788–789)

      Giovanni Musso, Maurizio Cassader and Roberto Gambino

      Article first published online: 25 JUL 2012 | DOI: 10.1002/hep.25677

    5. Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinoma (pages 789–790)

      Dominik Bettinger, Michael Schultheiβ, Eva Knüppel, Robert Thimme, Hubert E. Blum and Hans Christian Spangenberg

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25637

    6. Drug-related adverse events may predict efficacy in sorafenib therapy for hepatocellular carcinoma (pages 790–791)

      Yan Zhao, Man Yang, Xingshun Qi, Guohong Han and Daiming Fan

      Article first published online: 6 JUL 2012 | DOI: 10.1002/hep.25639

    7. I148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatology (page 791)

      Luca Valenti, Anna Alisi and Valerio Nobili

      Article first published online: 29 JUN 2012 | DOI: 10.1002/hep.25634

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