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Hepatology

Cover image for Vol. 58 Issue 6

December 2013

Volume 58, Issue 6

Pages 1869–2219, 1377A–1395A

  1. Hepatology Highlights

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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      Hepatology Highlights (pages 1869–1870)

      Jean-François Dufour

      Version of Record online: 26 NOV 2013 | DOI: 10.1002/hep.26780

  2. Editorials

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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    2. You have free access to this content
    3. You have free access to this content
    4. You have free access to this content
    5. You have free access to this content
  3. Viral Hepatitis

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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      Off-therapy durability of response to entecavir therapy in hepatitis B e antigen-negative chronic hepatitis B patients (pages 1888–1896)

      Wen-Juei Jeng, I-Shyan Sheen, Yi-Cheng Chen, Chao-Wei Hsu, Rong-Nan Chien, Chia-Ming Chu and Yun-Fan Liaw

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26549

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      Homeostasis model assessment of insulin resistance does not seem to predict response to telaprevir in chronic hepatitis C in the REALIZE trial (pages 1897–1906)

      Zobair Younossi, Francesco Negro, Lawrence Serfaty, Stanislas Pol, Moises Diago, Stefan Zeuzem, Pietro Andreone, Eric J. Lawitz, Stuart Roberts, Roberto Focaccia, Graham R. Foster, Andrzej Horban, Isabelle Lonjon-Domanec, Bruce Coate, Ralph DeMasi, Gaston Picchio and James Witek

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26437

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      Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers (pages 1907–1917)

      Rineke H.G. Steenbergen, Michael A. Joyce, Bradley S. Thomas, Daniel Jones, John Law, Rodney Russell, Michael Houghton and D. Lorne Tyrrell

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26566

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      Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-naïve genotype 1 hepatitis C: The randomized PILLAR study (pages 1918–1929)

      Michael W. Fried, Maria Buti, Gregory J. Dore, Robert Flisiak, Peter Ferenci, Ira Jacobson, Patrick Marcellin, Michael Manns, Igor Nikitin, Fred Poordad, Morris Sherman, Stefan Zeuzem, Jane Scott, Leen Gilles, Oliver Lenz, Monika Peeters, Vanitha Sekar, Goedele De Smedt and Maria Beumont-Mauviel

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26641

  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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      Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials (pages 1930–1940)

      Mazen Noureddin, Jessica Lam, Michael R. Peterson, Michael Middleton, Gavin Hamilton, Thuy-Anh Le, Ricki Bettencourt, Chris Changchien, David A. Brenner, Claude Sirlin and Rohit Loomba

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26455

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      Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (pages 1941–1952)

      Bart Staels, Anne Rubenstrunk, Benoit Noel, Géraldine Rigou, Philippe Delataille, Lesley J. Millatt, Morgane Baron, Anthony Lucas, Anne Tailleux, Dean W. Hum, Vlad Ratziu, Bertrand Cariou and Rémy Hanf

      Version of Record online: 29 OCT 2013 | DOI: 10.1002/hep.26461

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      Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice (pages 1953–1963)

      Ming Hu, Huquan Yin, Mayurranjan S. Mitra, Xiaomei Liang, Joanne M. Ajmo, Karim Nadra, Roman Chrast, Brian N. Finck and Min You

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26589

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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      Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region (pages 1964–1976)

      Chuan Yin, Pei-Qin Wang, Wen-Ping Xu, Yuan Yang, Qing Zhang, Bei-Fang Ning, Ping-Ping Zhang, Wei-Ping Zhou, Wei-Fen Xie, Wan-Sheng Chen and Xin Zhang

      Version of Record online: 22 OCT 2013 | DOI: 10.1002/hep.26573

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      Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma (pages 1977–1991)

      Wen-Ping Xu, Min Yi, Qian-Qian Li, Wei-Ping Zhou, Wen-Ming Cong, Yuan Yang, Bei-Fang Ning, Chuan Yin, Zhao-Wei Huang, Jian Wang, Hui Qian, Cai-Feng Jiang, Yue-Xiang Chen, Chun-Yan Xia, Hong-Yang Wang, Xin Zhang and Wei-Fen Xie

      Version of Record online: 30 OCT 2013 | DOI: 10.1002/hep.26541

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      Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma (pages 1992–2000)

      Laurent Sulpice, Michel Rayar, Mireille Desille, Bruno Turlin, Alain Fautrel, Eveline Boucher, Francisco Llamas-Gutierrez, Bernard Meunier, Karim Boudjema, Bruno Clément and Cédric Coulouarn

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26577

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      Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor (pages 2001–2011)

      Audrey Clapéron, Martine Mergey, Lynda Aoudjehane, Thanh Huong Nguyen Ho-Bouldoires, Dominique Wendum, Aurélie Prignon, Fatiha Merabtene, Delphine Firrincieli, Christèle Desbois-Mouthon, Olivier Scatton, Filomena Conti, Chantal Housset and Laura Fouassier

      Version of Record online: 25 OCT 2013 | DOI: 10.1002/hep.26585

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      Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma (pages 2012–2022)

      Hongbin Zhu, Kongming Wu, Wenji Yan, Ling Hu, Jing Yuan, Yan Dong, Yazhuo Li, Kunyu Jing, Yunsheng Yang and Mingzhou Guo

      Version of Record online: 21 OCT 2013 | DOI: 10.1002/hep.26587

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      Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second-line trial design (pages 2023–2031)

      Maria Reig, Jordi Rimola, Ferran Torres, Anna Darnell, Carlos Rodriguez-Lope, Alejandro Forner, Neus LLarch, José Ríos, Carmen Ayuso and Jordi Bruix

      Version of Record online: 29 OCT 2013 | DOI: 10.1002/hep.26586

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      Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells (pages 2032–2044)

      Esther Bertran, Eva Crosas-Molist, Patricia Sancho, Laia Caja, Judit Lopez-Luque, Estanislao Navarro, Gustavo Egea, Raquel Lastra, Teresa Serrano, Emilio Ramos and Isabel Fabregat

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26597

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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      Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis (pages 2045–2055)

      Kirsten Boonstra, Rinse K. Weersma, Karel J. van Erpecum, Erik A. Rauws, B.W. Marcel Spanier, Alexander C. Poen, Karin M. van Nieuwkerk, Joost P. Drenth, Ben J. Witteman, Hans A. Tuynman, Anton H. Naber, Paul J. Kingma, Henk R. van Buuren, Bart van Hoek, Frank P. Vleggaar, Nan van Geloven, Ulrich Beuers, Cyriel Y. Ponsioen and on behalf of the EpiPSCPBC Study Group

      Version of Record online: 17 OCT 2013 | DOI: 10.1002/hep.26565

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      Bile acids trigger cholemic nephropathy in common bile-duct–ligated mice (pages 2056–2069)

      Peter Fickert, Elisabeth Krones, Marion J. Pollheimer, Andrea Thueringer, Tarek Moustafa, Dagmar Silbert, Emina Halilbasic, Min Yang, Hartmut Jaeschke, Geurt Stokman, Rebecca G. Wells, Kathrin Eller, Alexander R. Rosenkranz, Gosta Eggertsen, Carsten A. Wagner, Cord Langner, Helmut Denk and Michael Trauner

      Version of Record online: 15 OCT 2013 | DOI: 10.1002/hep.26599

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      Randomized trial comparing monthly ibandronate and weekly alendronate for osteoporosis in patients with primary biliary cirrhosis (pages 2070–2078)

      Núria Guañabens, Anna Monegal, Dacia Cerdá, África Muxí, Laia Gifre, Pilar Peris and Albert Parés

      Version of Record online: 29 OCT 2013 | DOI: 10.1002/hep.26466

  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
      Rebleeding prophylaxis improves outcomes in patients with hepatocellular carcinoma. A multicenter case-control study (pages 2079–2088)

      Cristina Ripoll, Joan Genescà, Isis K. Araujo, Isabel Graupera, Salvador Augustin, Marta Tejedor, Isabel Cirera, Carles Aracil, Margarita Sala, Manuel Hernandez-Guerra, Elba Llop, Angels Escorsell, Maria Vega Catalina, Nuria Cañete, Agustin Albillos, Càndid Villanueva, Juan G. Abraldes, Rafael Bañares and Jaime Bosch

      Version of Record online: 15 OCT 2013 | DOI: 10.1002/hep.26629

  8. Liver Injury/Regeneration

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
      Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion (pages 2089–2098)

      Jie Xia, Yongjie Zhou, Hongjie Ji, Yujia Wang, Qiong Wu, Ji Bao, Feng Ye, Yujun Shi and Hong Bu

      Version of Record online: 7 OCT 2013 | DOI: 10.1002/hep.26542

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      Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice (pages 2099–2108)

      Anup Ramachandran, Mitchell R. McGill, Yuchao Xie, Hong-Min Ni, Wen-Xing Ding and Hartmut Jaeschke

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26547

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  9. Liver Biology/Pathobiology

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
      Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice (pages 2122–2132)

      Víctor Díaz, Elena Gammella, Stefania Recalcati, Paolo Santambrogio, Arianne Monge Naldi, Johannes Vogel, Max Gassmann and Gaetano Cairo

      Version of Record online: 21 OCT 2013 | DOI: 10.1002/hep.26550

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      AASLD clinical practice guidelines: A critical review of scientific evidence and evolving recommendations (pages 2142–2152)

      Christopher Koh, Xiongce Zhao, Niharika Samala, Sasan Sakiani, T. Jake Liang and Jayant A. Talwalkar

      Version of Record online: 18 OCT 2013 | DOI: 10.1002/hep.26578

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      Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers (pages 2153–2162)

      Oliver Goetze, Johannes Schmitt, Kerstin Spliethoff, Igor Theurl, Günter Weiss, Dorine W. Swinkels, Harold Tjalsma, Marco Maggiorini, Pierre Krayenbühl, Monika Rau, Heiko Fruehauf, Kacper A. Wojtal, Beat Müllhaupt, Michael Fried, Max Gassmann, Thomas Lutz and Andreas Geier

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26581

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      CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice (pages 2163–2175)

      Osamu Yoshida, Shoko Kimura, Edwin K. Jackson, Simon C. Robson, David A. Geller, Noriko Murase and Angus W. Thomson

      Version of Record online: 15 OCT 2013 | DOI: 10.1002/hep.26593

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  10. Review

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
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  11. Hepatology Elsewhere

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
    2. You have free access to this content
  12. Clinical Observations in Hepatology

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
  13. Correspondence

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
    2. You have free access to this content
    3. You have free access to this content
      Reply (page 2208)

      Yasuji Arase, Mariko Kobayashi and Hiromitsu Kumada

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26456

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      The AlfpCre mouse revisited: Evidence for liver steatosis related to growth hormone deficiency (pages 2209–2210)

      Vincent P.E.G. Pruniau, Els Louagie, Bas Brouwers, Jeroen Declercq and John W.M. Creemers

      Version of Record online: 23 OCT 2013 | DOI: 10.1002/hep.26483

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      Reply (page 2210)

      Kristina M. Mueller and Richard Moriggl

      Version of Record online: 7 OCT 2013 | DOI: 10.1002/hep.26545

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      Influence of the transjugular intrahepatic portosystemic stent on firstline treatment of hepatocellular carcinoma (pages 2211–2212)

      Eva Knüppel, Dominik Bettinger, Wulf Euringer, Robert Thimme, Martin Roessle, Hans Christian Spangenberg and Michael Schultheiss

      Version of Record online: 21 OCT 2013 | DOI: 10.1002/hep.26406

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      Reply (pages 2212–2213)

      Jerzy W. Kupiec-Weglinski and Naoko Kamo

      Version of Record online: 11 OCT 2013 | DOI: 10.1002/hep.26473

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      NK cells of mice phagocytose hMSCs (pages 2213–2214)

      Jin-Zhong Dong, Li-Ping Wang, Chun-Wei Shi, Sai-Nan Zhang and Ming-Qin Lu

      Version of Record online: 24 OCT 2013 | DOI: 10.1002/hep.26451

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      Reply (page 2214)

      Stefania Bruno, Ciro Tetta and Giovanni Camussi

      Version of Record online: 24 OCT 2013 | DOI: 10.1002/hep.26450

  14. Referees

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content
  15. AASLD Abstracts

    1. Top of page
    2. Hepatology Highlights
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Review
    12. Hepatology Elsewhere
    13. Clinical Observations in Hepatology
    14. Correspondence
    15. Referees
    16. AASLD Abstracts
    1. You have free access to this content

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