Virtual interactive design methodology was initially proposed as an integrated environment for digital human model–based ergonomics analysis of human–machine interactions, which uses a motion capture system and virtual environment to realize task simulation. The validity and reliability of this analysis methodology has not been systematically studied. In this article, potential errors are first investigated based on the technology used in the system structure and work process; then, three experimental integration levels are proposed to use different resources for creating manikin postures. Validity and reliability to use this integrated environment for static ergonomics analysis are then assessed by comparing the ergonomics analysis outputs achieved based on the three integration levels. The results indicate that the reliability of this methodology is good; however, the validity of the integrated system is affected by the limitation of the virtual environment used in the testing. © 2011 Wiley Periodicals, Inc.