Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus
Article first published online: 22 APR 2002
Copyright © 2002 Wiley-Liss, Inc.
Volume 12, Issue 3, pages 398–404, 2002
How to Cite
Tang, A. C. and Zou, B. (2002), Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus. Hippocampus, 12: 398–404. doi: 10.1002/hipo.10017
- Issue published online: 22 APR 2002
- Article first published online: 22 APR 2002
- Manuscript Accepted: 24 AUG 2001
- in vitro;
- neonatal handling;
Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cessation of the environmental manipulation remain unknown. Using a novelty exposure procedure modified from the method of neonatal handling, we exposed neonatal rats to a non-home environment for 3 min/day during the first 3 weeks of life. We examined the LTP of both population spikes and excitatory postsynaptic potentials (EPSPs), in vitro, in the CA1 of the hippocampus during adulthood (7–8 and 13–14 months of age). We found that both the LTP of population spikes and the LTP of EPSPs were enhanced among animals who experienced neonatal novelty exposure. These results demonstrate that effective environmental enhancement of LTP can be achieved by as brief and as transient a manipulation as a 3-min/day exposure over the first 3 weeks of life. The resulting enhancement can outlast the environmental manipulation by at least 1 year. Hippocampus 2002;12:398–404. © 2002 Wiley-Liss, Inc.