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Research Article
What went where? Impaired object-location learning in patients with right hippocampal lesions
Article first published online: 7 SEP 2004
DOI: 10.1002/hipo.20043
Copyright © 2004 Wiley-Liss, Inc.
Additional Information
How to Cite
Crane, J. and Milner, B. (2005), What went where? Impaired object-location learning in patients with right hippocampal lesions. Hippocampus, 15: 216–231. doi: 10.1002/hipo.20043
Publication History
- Issue published online: 3 MAR 2005
- Article first published online: 7 SEP 2004
- Manuscript Accepted: 20 JUL 2004
Funded by
- Medical Research Council of Canada. Grant Numbers: MT-2624, ST-40611
- McDonnell-Pew Program in Cognitive Neuroscience. Grant Number: 94-44
- Abstract
- References
- Cited By
Keywords:
- object-location memory;
- medial temporal lobe;
- hippocampus;
- temporal lobectomy;
- selective amygdalo-hippocampectomy
Abstract
The role of the right medial temporal-lobe structures in memory for object location was investigated in three studies. In the first two studies, 118 patients with selective amygdalo-hippocampectomy or with anterior temporal lobectomy (either invading or largely sparing the hippocampal region) and 33 healthy participants were tested on array learning. Groups with extensive right hippocampal lesions were impaired on immediate and delayed recall and on learning to criterion. In the third study, magnetic resonance imaging (MRI) was used in 75 of these patients to measure the extent of tissue remaining in the various medial temporal-lobe structures. The extent of right hippocampus remaining was found to be the best predictor of array-learning performance, underlining its critical role in building a representation of objects in space. © 2004 Wiley-Liss, Inc.