This article is a US Government work and, as such, is in the public domain in the United States of America.
Dynamic mapping of normal human hippocampal development†
Article first published online: 6 JUL 2006
Published 2006 Wiley-Liss, Inc.
Volume 16, Issue 8, pages 664–672, August 2006
How to Cite
Gogtay, N., Nugent, T. F., Herman, D. H., Ordonez, A., Greenstein, D., Hayashi, K. M., Clasen, L., Toga, A. W., Giedd, J. N., Rapoport, J. L. and Thompson, P. M. (2006), Dynamic mapping of normal human hippocampal development. Hippocampus, 16: 664–672. doi: 10.1002/hipo.20193
- Issue published online: 26 JUL 2006
- Article first published online: 6 JUL 2006
- Manuscript Accepted: 17 MAY 2006
- NIH. Grant Numbers: R21 EB01651, R21 RR019771, P50 AG016570, U54 RR021813, P41 RR13642
- hippocampal mapping technique;
- developmental trajectories
The hippocampus, which plays an important role in memory functions and emotional responses, has distinct subregions subserving different functions. Because the volume and shape of the hippocampus are altered in many neuropsychiatric disorders, it is important to understand the trajectory of normal hippocampal development. We present the first dynamic maps to reveal the anatomical sequence of normal human hippocampal development. A novel hippocampal mapping technique was applied to a database of prospectively obtained brain magnetic resonance imaging (MRI) scans (100 scans in 31 children and adolescents), scanned every 2 yr for 6–10 yr between ages 4 and 25. Our results establish that the structural development of the human hippocampus is remarkably heterogeneous, with significant differences between posterior (increase over time) and anterior (loss over time) subregions. These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development. Published 2006 Wiley-Liss, Inc.