Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas
Version of Record online: 19 NOV 2008
Copyright © 2008 Wiley-Liss, Inc.
Special Issue: Grid Cells
Volume 18, Issue 12, pages 1314–1324, December 2008
How to Cite
Eichenbaum, H. and Lipton, P. A. (2008), Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas. Hippocampus, 18: 1314–1324. doi: 10.1002/hipo.20500
- Issue online: 19 NOV 2008
- Version of Record online: 19 NOV 2008
- Manuscript Accepted: 12 AUG 2008
- NIMH. Grant Numbers: MH51570, MH071702
- NSF. Grant Number: SBE0354378
- episodic memory;
- spatial navigation;
- temporal context
Whereas substantial recent evidence has suggested to some that the medial entorhinal cortexá (MEC) plays a specialized role in spatial navigation, here we present evidence consistent with a broader role of the MEC in memory. A consideration of evidence on the anatomy and functional roles of medial temporal cortical areas and the hippocampus, and evidence from recordings from MEC neurons in rats performing a spatial memory task, suggest that the MEC may process information about both spatial and temporal context in support of episodic memory. © 2008 Wiley-Liss, Inc.