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Keywords:

  • episodic memory;
  • hippocampus;
  • spatial navigation;
  • T-maze;
  • temporal context

Abstract

Whereas substantial recent evidence has suggested to some that the medial entorhinal cortexá (MEC) plays a specialized role in spatial navigation, here we present evidence consistent with a broader role of the MEC in memory. A consideration of evidence on the anatomy and functional roles of medial temporal cortical areas and the hippocampus, and evidence from recordings from MEC neurons in rats performing a spatial memory task, suggest that the MEC may process information about both spatial and temporal context in support of episodic memory. © 2008 Wiley-Liss, Inc.