Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis
Version of Record online: 11 FEB 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 19, Issue 10, pages 928–936, October 2009
How to Cite
Van der Borght, K., Kóbor-Nyakas, D. É., Klauke, K., Eggen, B. J.L., Nyakas, C., Van der Zee, E. A. and Meerlo, P. (2009), Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis. Hippocampus, 19: 928–936. doi: 10.1002/hipo.20545
- Issue online: 23 SEP 2009
- Version of Record online: 11 FEB 2009
- Manuscript Accepted: 20 NOV 2008
- Netherlands Organization for Scientific Research. Grant Number: 864.04.002
- Hungarian Scientific Research Fund. Grant Number: K68875
- Hungarian Ministry of Health. Grant Number: ETT 21/2,006
- running wheel activity;
- cerebrovascular system;
- neuronal plasticity
Increased levels of angiogenesis and neurogenesis possibly mediate the beneficial effects of physical activity on hippocampal plasticity. This study was designed to investigate the temporal dynamics of exercise-induced changes in hippocampal angiogenesis and cell proliferation. Mice were housed with a running wheel for 1, 3, or 10 days. Analysis of glucose transporter Glut1-positive vessel density showed a significant increase after 3 days of wheel running. Cell proliferation in the dentate gyrus showed a trend towards an increase after 3 days of running and was significantly elevated after 10 days of physical exercise. Ten days of wheel running resulted in a near-significant increase in the number of immature neurons, as determined by a doublecortin (DCX) staining. In the second part of the study, the persistence of the exercise-induced changes in angiogenesis and cell proliferation was determined. The running wheel was removed from the cage after 10 days of physical activity. Glut-1 positive vessel density and hippocampal cell proliferation were determined 1 and 6 days after removal of the wheel. Both parameters had returned to baseline 24 h after cessation of physical activity. The near-significant increase in the number of DCX-positive immature neurons persisted for at least 6 days, indicating that new neurons formed during the period of increased physical activity had survived. Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity. © 2009 Wiley-Liss, Inc.