Exercise enhances hippocampal-dependent learning in the rat: Evidence for a BDNF-related mechanism
Article first published online: 12 MAY 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 19, Issue 10, pages 973–980, October 2009
How to Cite
Griffin, É. W., Bechara, R. G., Birch, A. M. and Kelly, Á. M. (2009), Exercise enhances hippocampal-dependent learning in the rat: Evidence for a BDNF-related mechanism. Hippocampus, 19: 973–980. doi: 10.1002/hipo.20631
- Issue published online: 23 SEP 2009
- Article first published online: 12 MAY 2009
- Manuscript Accepted: 20 MAR 2009
- Irish Research Council for Science, Engineering and Technology (Embark Initiative)
- Health Research Board, Ireland
- perirhinal cortex
Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spatial) and object substitution (nonspatial) learning. These behavioral changes were accompanied by increased expression of BDNF protein in the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on object substitution were mimicked by intracerebroventricular injection of BDNF protein. These data are consistent with the hypothesis that exercise has the potential to enhance cognitive function in young healthy rats, possibly via a mechanism involving increased BDNF expression in specific brain regions. © 2009 Wiley-Liss, Inc.