Right-hemispheric dominance of spatial memory in split-brain mice

Authors

  • Yoshiaki Shinohara,

    Corresponding author
    1. Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan
    2. RIKEN Brain Science Institute, Wako, Saitama, Japan
    • RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
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  • Aki Hosoya,

    1. RIKEN Brain Science Institute, Wako, Saitama, Japan
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  • Nobuyuki Yamasaki,

    1. Frontier Technology Center, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
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  • Hassan Ahmed,

    1. Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan
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  • Satoko Hattori,

    1. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    2. Section of Behavior Analysis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan
    3. CREST, JST, Kawaguchi, Japan
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  • Megumi Eguchi,

    1. Division of Developmental Neurobiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan
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  • Shun Yamaguchi,

    1. Division of Developmental Neurobiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    2. PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Japan
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  • Tsuyoshi Miyakawa,

    1. Frontier Technology Center, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
    2. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    3. Section of Behavior Analysis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan
    4. CREST, JST, Kawaguchi, Japan
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  • Hajime Hirase,

    1. RIKEN Brain Science Institute, Wako, Saitama, Japan
    2. Saitama University Brain Science Institute, Saitama, Japan
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    • Hajime Hirase and Ryuichi Shigemoto contributed equally to this work.

  • Ryuichi Shigemoto

    1. Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan
    2. CREST, JST, Kawaguchi, Japan
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    • Hajime Hirase and Ryuichi Shigemoto contributed equally to this work.


Abstract

Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of “split-brain” mice in the Barnes maze. The “split-brain” mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus. © 2010 Wiley Periodicals, Inc.

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