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Research Article
Selective facilitation of LTP in the ventral hippocampus by calcium stores
Article first published online: 23 JAN 2012
DOI: 10.1002/hipo.22000
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Grigoryan, G., Korkotian, E. and Segal, M. (2012), Selective facilitation of LTP in the ventral hippocampus by calcium stores. Hippocampus. doi: 10.1002/hipo.22000
Publication History
- Article first published online: 23 JAN 2012
- Manuscript Accepted: 24 NOV 2011
Funded by
- German Israel Foundation
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Keywords:
- ventral hippocampus;
- slices;
- LTP;
- ryanodine receptors;
- calcium stores
Abstract
The effects of low concentrations of caffeine and ryanodine on field excitatory postsynaptic potentials (EPSPs) and long-term potentiation (LTP) were studied in CA1 region of slices of dorsal and ventral hippocampus (DH and VH, respectively). There was a striking difference between the two regions in the magnitude of effect of both drugs, as well as the ability to interact with a tetanic stimulation to produce LTP. Low concentration of caffeine (1 mM) produced a postsynaptic increase in the slope of population EPSPs in VH, and facilitated LTP in this region. Low concentration of ryanodine (0.2 μM) was able to convert short-term potentiation (STP) to LTP in VH only. These effects are postsynaptic and they reflect a higher concentration of ryanodine receptors (RyRs) in the VH compared to the DH. © 2012 Wiley Periodicals, Inc.