Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning

Authors

  • Justin W. Kenney,

    1. Department of Psychology, Temple University, Weiss Hall, Philadelphia, Pennsylvania
    Current affiliation:
    1. University of Southampton, Centre for Biological Sciences, Southampton, SO17 1BJ, UK
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  • Jonathan D. Raybuck,

    1. Department of Psychology, Temple University, Weiss Hall, Philadelphia, Pennsylvania
    Current affiliation:
    1. Oregon Health Science University, Department of Behavioral Neuroscience, Portland, OR 97239, USA
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  • Thomas J. Gould

    Corresponding author
    1. Department of Psychology, Temple University, Weiss Hall, Philadelphia, Pennsylvania
    • Department of Psychology, Temple University, Weiss Hall, Philadelphia, PA 19122
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Abstract

Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning. © 2012 Wiley Periodicals, Inc.

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