This article was published online on 26 April 2012. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected on 7 May 2012.
Dynamics of decision-related activity in hippocampus†
Article first published online: 26 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 22, Issue 9, pages 1901–1911, September 2012
How to Cite
Catanese, J., Cerasti, E., Zugaro, M., Viggiano, A. and Wiener, S. I. (2012), Dynamics of decision-related activity in hippocampus. Hippocampus, 22: 1901–1911. doi: 10.1002/hipo.22025
- Issue published online: 29 AUG 2012
- Article first published online: 26 APR 2012
- Manuscript Accepted: 12 MAR 2012
- European Community. Grant Number: FP6-IST-027819 (ICEA)
- European Community. Grant Number: FP6-IST-027140 (BACS)
- Fondation pour la Recherche Médicale. Grant Number: SPF20110421459
- French Agence National pour la Recherche. Grant Number: ANR-10-BLAN-02 (Neurobot)
- Paris Neuroscience School
- Fondation pour la Recherche Médical. Grant Number: FDT20110922969
- trajectory planning;
- response latency;
- prospective activity;
- place cell;
- contextual responses
Place-selective activity in hippocampal neurons can be modulated by the trajectory that will be taken in the immediate future (“prospective coding”), information that could be useful in neural processes elaborating choices in route planning. To determine if and how hippocampal prospective neurons participate in decision making, we measured the time course of the evolution of prospective activity by recording place responses in rats performing a T-maze alternation task. After five or seven alternation trials, the routine was unpredictably interrupted by a photodetector-triggered visual cue as the rat crossed the middle of central arm, signaling it to suddenly change its intended choice. Comparison of the delays between light cue presentation and the onset of prospective activity for neurons with firing fields at various locations after the trigger point revealed a 420 ms processing delay. This surprisingly long delay indicates that prospective activity in the hippocampus appears much too late to generate planning or decision signals. This provides yet another example of a prominent brain activity that is unlikely to play a functional role in the cognitive function that it appears to represent (planning future trajectories). Nonetheless, the hippocampus may provide other contextual information to areas active at the earliest stages of selecting future paths, which would then return signals that help establish hippocampal prospective activity. © 2012 Wiley Periodicals, Inc.