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Regulation of archicortical arealization by the transcription factor Zbtb20

Authors

  • Eva H. Rosenthal,

    1. Max Planck Institute for Biophysical Chemistry, Am Fassberg, Goettingen, Germany
    Current affiliation:
    1. Molecular Neurobiology Laboratory, Medical Biotechnology Center, Department of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, 5000 Odense C, Denmark
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  • Anton B. Tonchev,

    1. Max Planck Institute for Biophysical Chemistry, Am Fassberg, Goettingen, Germany
    2. Molecular Developmental Neurobiology Laboratory, Goettingen, Germany
    Current affiliation:
    1. Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University, BG-9002 Varna, Bulgaria
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  • Anastassia Stoykova,

    Corresponding author
    1. Max Planck Institute for Biophysical Chemistry, Am Fassberg, Goettingen, Germany
    2. Molecular Developmental Neurobiology Laboratory, Goettingen, Germany
    3. DFG Research Center for the Molecular Physiology of the Brain (CMPB), Goettingen, Germany
    • Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Goettingen, Germany
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  • Kamal Chowdhury

    1. Max Planck Institute for Biophysical Chemistry, Am Fassberg, Goettingen, Germany
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  • This article was published online on June 11, 2012. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected on 6 July 2012.

Abstract

The molecular mechanisms of regionalization of the medial pallium (MP), the anlage of the hippocampus, and transitional (cingulate and retrosplenial) cortices are largely unknown. Previous analyses have outlined an important role of the transcription factor (TF) Zbtb20 for hippocampal CA1 field specification (Nielsen et al. (2007) Development 134:1133-1140; Nielsen et al. (2010) Cereb Cortex 20:1904-1914; Xie et al. (2010) Proc Natl Acad Sci USA 107:6510-6515). Here, we present novel data showing that Zbtb20 exhibits a ventralhigh-to-dorsallow gradient of expression in MP progenitors as well as an expression in postmitotic cells at the transitional cortex/neocortex border. Our detailed pattern analysis revealed that in Zbtb20 loss-of-function the molecular borders between neocortical, transitional, and hippocampal fields are progressively shifted ventrally, leading to an ectopic positioning of all dorsal fields into the neighboring ventrally located areas. Thus, in addition to its known importance for the specification of the hippocampal CA1 sector, the graded expression of TF Zbtb20 in ventricular zone of MP appears to translate early positional information for establishment of all developing MP fields. Our data also suggest that the signaling factor Wnt3a is a putative molecular partner of TF Zbtb20 in this patterning process. © 2012 Wiley Periodicals, Inc.

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