Increased functional connectivity within medial temporal lobe in mild cognitive impairment

Authors

  • Sandhitsu R. Das,

    Corresponding author
    1. Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
    • Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA
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  • John Pluta,

    1. Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
    2. Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Lauren Mancuso,

    1. Alzheimer Disease Center, University of Pennsylvania, Philadelphia, Pennsylvania
    2. Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania
    3. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Dasha Kliot,

    1. Alzheimer Disease Center, University of Pennsylvania, Philadelphia, Pennsylvania
    2. Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania
    3. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Sylvia Orozco,

    1. Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Bradford C. Dickerson,

    1. Frontotemporal Dementia Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    2. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    3. Massachusetts Alzheimers Disease Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    4. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
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  • Paul A. Yushkevich,

    1. Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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  • David A. Wolk

    1. Alzheimer Disease Center, University of Pennsylvania, Philadelphia, Pennsylvania
    2. Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania
    3. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
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Abstract

Pathology at preclinical and prodromal stages of Alzheimer's disease (AD) may manifest itself as measurable functional change in neuronal networks earlier than detectable structural change. Functional connectivity as measured using resting-state functional magnetic resonance imaging has emerged as a useful tool for studying disease effects on baseline states of neuronal networks. In this study, we use high resolution MRI to label subregions within the medial temporal lobe (MTL), a site of early pathology in AD, and report an increase in functional connectivity in amnestic mild cognitive impairment between entorhinal cortex and subregions of the MTL, with the strongest effect in the anterior hippocampus. However, our data also replicated the effects of decreased connectivity of the MTL to other nodes of the default mode network reported by other researchers. This dissociation of changes in functional connectivity within the MTL versus the MTL's connection with other neocortical structures can help enrich the characterization of early stages of disease progression in AD. © 2012 Wiley Periodicals, Inc.

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