Increased functional connectivity within medial temporal lobe in mild cognitive impairment
Version of Record online: 20 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 23, Issue 1, pages 1–6, January 2013
How to Cite
Das, S. R., Pluta, J., Mancuso, L., Kliot, D., Orozco, S., Dickerson, B. C., Yushkevich, P. A. and Wolk, D. A. (2013), Increased functional connectivity within medial temporal lobe in mild cognitive impairment. Hippocampus, 23: 1–6. doi: 10.1002/hipo.22051
- Issue online: 11 DEC 2012
- Version of Record online: 20 JUL 2012
- Manuscript Accepted: 29 MAY 2012
- Penn-Pfizer Alliance. Grant Numbers: 10295, NIH K25 AG027785, NIH K23 AG028018, NIH R01 AG037376, NIH R01 AG029411, NIH P50 AG005134, NIH P30 AG010124
- functional connectivity;
- medial temporal lobe;
- entorhinal cortex;
Pathology at preclinical and prodromal stages of Alzheimer's disease (AD) may manifest itself as measurable functional change in neuronal networks earlier than detectable structural change. Functional connectivity as measured using resting-state functional magnetic resonance imaging has emerged as a useful tool for studying disease effects on baseline states of neuronal networks. In this study, we use high resolution MRI to label subregions within the medial temporal lobe (MTL), a site of early pathology in AD, and report an increase in functional connectivity in amnestic mild cognitive impairment between entorhinal cortex and subregions of the MTL, with the strongest effect in the anterior hippocampus. However, our data also replicated the effects of decreased connectivity of the MTL to other nodes of the default mode network reported by other researchers. This dissociation of changes in functional connectivity within the MTL versus the MTL's connection with other neocortical structures can help enrich the characterization of early stages of disease progression in AD. © 2012 Wiley Periodicals, Inc.