On the role of retrosplenial cortex in long-lasting memory storage
Article first published online: 28 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 23, Issue 4, pages 295–302, April 2013
How to Cite
Katche, C., Dorman, G., Gonzalez, C., Kramar, C. P., Slipczuk, L., Rossato, J. I., Cammarota, M. and Medina, J. H. (2013), On the role of retrosplenial cortex in long-lasting memory storage. Hippocampus, 23: 295–302. doi: 10.1002/hipo.22092
- Issue published online: 21 MAR 2013
- Article first published online: 28 JAN 2013
- Manuscript Accepted: 18 DEC 2012
- National Agency of Scientific and Technological Promotion of Argentina (ANPCyT). Grant Number: PICT1169
- University of Buenos Aires, Argentina (UBACyT)
- National Research Council of Brazil
- protein synthesis;
- memory persistence;
The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time. © 2013 Wiley Periodicals, Inc.