Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment
Article first published online: 21 MAY 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 23, Issue 9, pages 812–819, September 2013
How to Cite
Alzoubi, Karem. H., Khabour, Omar. F., Tashtoush, N. H., Al-azzam, S. I. and Mhaidat, N. M. (2013), Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment. Hippocampus, 23: 812–819. doi: 10.1002/hipo.22135
- Issue published online: 23 AUG 2013
- Article first published online: 21 MAY 2013
- Accepted manuscript online: 17 APR 2013 03:24AM EST
- Manuscript Accepted: 5 APR 2013
- Deanship of Research at the Jordan University of Science and Technology. Grant Number: 229/2010
- sleep deprivation;
In this study, we examined the ability of Pentoxifylline (PTX) to prevent sleep deprivation induced memory impairment probably through decreasing oxidative stress. Sleep deprivation was chronically induced 8 h/day for 6 weeks in rats using modified multiple platform model. Concurrently, PTX (100 mg/kg) was administered to animals on daily basis. After 6 weeks of treatment, behavioral studies were conducted to test the spatial learning and memory using the Radial Arm Water Maze. Additionally, the hippocampus was dissected; and levels/activities of antioxidant defense biomarkers glutathione reduced (GSH), glutathione oxidized (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD), were assessed. The results show that chronic sleep deprivation impaired short- and long-term memories, which was prevented by chronic treatment with PTX. Additionally, PTX normalized sleep deprivation-induced reduction in the hippocampus GSH/GSSG ratio (P < 0.05), and activities of GPx, catalase, and SOD (P < 0.05). In conclusion, chronic sleep deprivation induces memory impairment, and treatment with PTX prevented this impairment probably through normalizing antioxidant mechanisms in the hippocampus. © 2013 Wiley Periodicals, Inc.