Quantitative assessment of CA1 local circuits: Knowledge base for interneuron-pyramidal cell connectivity
Article first published online: 10 JUL 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 23, Issue 9, pages 751–785, September 2013
How to Cite
Bezaire, M. J. and Soltesz, I. (2013), Quantitative assessment of CA1 local circuits: Knowledge base for interneuron-pyramidal cell connectivity. Hippocampus, 23: 751–785. doi: 10.1002/hipo.22141
- Issue published online: 23 AUG 2013
- Article first published online: 10 JUL 2013
- Accepted manuscript online: 15 MAY 2013 02:31AM EST
- Manuscript Accepted: 26 APR 2013
- Manuscript Revised: 25 APR 2013
- Manuscript Received: 15 MAR 2013
- National Institutes of Health; Grant number: NS35915 (to I.S.)
- National Science Foundation. Grant Number: DGE-0808392 (to M.B.)
- big data;
In this work, through a detailed literature review, data-mining, and extensive calculations, we provide a current, quantitative estimate of the cellular and synaptic constituents of the CA1 region of the rat hippocampus. Beyond estimating the cell numbers of GABAergic interneuron types, we calculate their convergence onto CA1 pyramidal cells and compare it with the known input synapses on CA1 pyramidal cells. The convergence calculation and comparison are also made for excitatory inputs to CA1 pyramidal cells. In addition, we provide a summary of the excitatory and inhibitory convergence onto interneurons. The quantitative knowledge base assembled and synthesized here forms the basis for data-driven, large-scale computational modeling efforts. Additionally, this work highlights specific instances where the available data are incomplete, which should inspire targeted experimental projects toward a more complete quantification of the CA1 neurons and their connectivity. © 2013 Wiley Periodicals, Inc.