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Hippocampal negative event-related potential recorded in humans during a simple sensorimotor task occurs independently of motor execution

Authors

  • Robert Roman,

    Corresponding author
    1. Department of Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    2. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    • Correspondence to: Robert Roman, Department of Physiology, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic. E-mail: roman@med.muni.cz

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  • Milan Brázdil,

    1. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    2. Department of Neurology, St. Anne Hospital, Masaryk University, Brno, Czech Republic
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  • Jan Chládek,

    1. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    2. Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic
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  • Ivan Rektor,

    1. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    2. Department of Neurology, St. Anne Hospital, Masaryk University, Brno, Czech Republic
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  • Pavel Jurák,

    1. Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic
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  • Miroslav Světlák,

    1. Department of Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic
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  • Alena Damborská,

    1. Department of Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    2. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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  • Daniel J. Shaw,

    1. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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  • Miloslav Kukleta

    1. CEITEC, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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ABSTRACT

A hippocampal-prominent event-related potential (ERP) with a peak latency at around 450 ms is consistently observed as a correlate of hippocampal activity during various cognitive tasks. Some intracranial EEG studies demonstrated that the amplitude of this hippocampal potential was greater in response to stimuli requiring an overt motor response, in comparison with stimuli for which no motor response is required. These findings could indicate that hippocampal-evoked activity is related to movement execution as well as stimulus evaluation and associated memory processes. The aim of the present study was to investigate the temporal relationship between the hippocampal negative potential latency and motor responses. We analyzed ERPs recorded with 22 depth electrodes implanted into the hippocampi of 11 epileptic patients. Subjects were instructed to press a button after the presentation of a tone. All investigated hippocampi generated a prominent negative ERP peaking at ∼420 ms. In 16 from 22 cases, we found that the ERP latency did not correlate with the reaction time; in different subjects, this potential could either precede or follow the motor response. Our results indicate that the hippocampal negative ERP occurs independently of motor execution. We suggest that hippocampal-evoked activity, recorded in a simple sensorimotor task, is related to the evaluation of stimulus meaning within the context of situation. © 2013 Wiley Periodicals, Inc.

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