Hippocampal correlates of depression in healthy elderly adults
Article first published online: 2 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 23, Issue 12, pages 1137–1142, December 2013
How to Cite
Ezzati, A., Zimmerman, M. E., Katz, M. J. and Lipton, R. B. (2013), Hippocampal correlates of depression in healthy elderly adults. Hippocampus, 23: 1137–1142. doi: 10.1002/hipo.22185
- Issue published online: 20 NOV 2013
- Article first published online: 2 OCT 2013
- Accepted manuscript online: 12 AUG 2013 08:06AM EST
- Manuscript Accepted: 6 AUG 2013
- National Institute on Aging. Grant Number: AG03949, AG026728
Mixed findings have been reported on the relationship between hippocampal integrity and major depression in clinical populations. Few neuroimaging studies have investigated associations between hippocampal measures and depressive symptoms in nondemented older adults. Here, we address this issue by imaging 36 nondemented adults over age 70 from the Einstein Aging Study, a community-based sample from the Bronx, NY. Depressive symptoms were assessed using the 15-item Geriatric Depression scale (GDS). Clinically significant depression was defined using a cut-off score of 5 or greater. Hippocampal data included MRI-derived volume data normalized to midsagittal area and MRS-derived N-acetylaspartate to creatine ratios (NAA/Cr). Our result indicates that smaller total hippocampal volume was associated with higher GDS scores, but there were no significant association between hippocampal NAA/Cr and GDS score. These effects were consistent after controlling for age, education, and gender. Reduction in hippocampal volume could represent a risk factor or a consequence of depression in older adults. Further studies are needed to better understand the role of the hippocampus in the development and experience of depression in older adults. © 2013 Wiley Periodicals, Inc.