Tactile modulation of hippocampal place fields
Article first published online: 2 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 23, Issue 12, pages 1453–1462, December 2013
How to Cite
Gener, T., Perez-Mendez, L. and Sanchez-Vives, M. V. (2013), Tactile modulation of hippocampal place fields. Hippocampus, 23: 1453–1462. doi: 10.1002/hipo.22198
- Issue published online: 20 NOV 2013
- Article first published online: 2 OCT 2013
- Accepted manuscript online: 31 AUG 2013 05:44AM EST
- Manuscript Accepted: 22 AUG 2013
- EU project PRESENCCIA. Grant Number: FP6-027731
- MINECO. Grant Number: BFU2011-27094
- place cells;
- spatial navigation;
- spatial processing;
Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, being the influence of visual inputs the most thoroughly studied. Tactile information gathered by the whiskers has a prominent representation in the rat cerebral cortex. However, the influence of whisker-detected tactile cues on place fields remains an open question. Here we studied place fields in an enriched tactile environment where the remaining sensory cues were occluded. First, place cells were recorded before and after blockade of tactile transmission by means of lidocaine applied on the whisker pad. Following tactile deprivation, the majority of place cells decreased their firing rate and their place fields expanded. We next rotated the tactile cues and 90% of place fields rotated with them. Our results demonstrate that tactile information is integrated into place cells at least in a tactile-enriched arena and when other sensory cues are not available. © 2013 Wiley Periodicals, Inc.