Anterior–posterior cerebral blood volume gradient in human subiculum
Article first published online: 24 FEB 2014
Copyright © 2014 Wiley Periodicals, Inc.
Volume 24, Issue 5, pages 503–509, May 2014
How to Cite
Talati, P., Rane, S., Kose, S., Gore, J. and Heckers, S. (2014), Anterior–posterior cerebral blood volume gradient in human subiculum. Hippocampus, 24: 503–509. doi: 10.1002/hipo.22257
- Issue published online: 4 APR 2014
- Article first published online: 24 FEB 2014
- Accepted manuscript online: 12 FEB 2014 05:57AM EST
- Manuscript Revised: 31 JAN 2014
- Manuscript Accepted: 31 JAN 2014
- Manuscript Received: 4 DEC 2013
- National Center for Advancing Translational Sciences of the National Institutes of Health . Grant Number: UL1 TR000445
- National Institute of General Medical Studies . Grant Number: T32 GM07347
- National Institute of Mental Health . Grant Number: MH070560
The human hippocampal formation is characterized by anterior–posterior gradients of cell density, neurochemistry, and hemodynamics. In addition, some functions are associated with specific subfields (subiculum, CA1–4, dentate gyrus) and regions (anterior and posterior). We performed contrast-enhanced, high-resolution T1-weighted 3T steady state (SS) imaging to investigate cerebral blood volume (CBV) gradients of the hippocampal formation. We studied 14 healthy subjects and found significant CBV gradients (anterior > posterior) in the subiculum but not in other hippocampal subfields. Since CBV is a marker of basal metabolism, these results indicate a greater baseline activity in the anterior compared with the posterior subiculum. This gradient might be related to the role of the subiculum as the main outflow station of the hippocampal formation and might have implications for the mechanisms of neuropsychiatric disorders. © 2014 Wiley Periodicals, Inc.