Hippocampal corticosterone impairs memory consolidation during sleep but improves consolidation in the wake state
Article first published online: 17 MAR 2014
Copyright © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 24, Issue 5, pages 510–515, May 2014
How to Cite
Kelemen, E., Bahrendt, M., Born, J. and Inostroza, M. (2014), Hippocampal corticosterone impairs memory consolidation during sleep but improves consolidation in the wake state. Hippocampus, 24: 510–515. doi: 10.1002/hipo.22266
- Issue published online: 4 APR 2014
- Article first published online: 17 MAR 2014
- Accepted manuscript online: 4 MAR 2014 11:40PM EST
- Manuscript Accepted: 27 FEB 2014
- Deutsche Forschungsgemeinschaft. Grant Number: SFB 654
We studied the interaction between glucocorticoid (GC) level and sleep/wake state during memory consolidation. Recent research has accumulated evidence that sleep supports memory consolidation in a unique physiological process, qualitatively distinct from consolidation occurring during wakefulness. This appears particularly true for memories that rely on the hippocampus, a region with abundant expression of GC receptors. Against this backdrop we hypothesized that GC effects on consolidation depend on the brain state, i.e., sleep and wakefulness. Following exploration of two objects in an open field, during 80 min retention periods rats received an intrahippocampal infusion of corticosterone (10 ng) or vehicle while asleep or awake. Then the memory was tested in the hippocampus-dependent object-place recognition paradigm. GCs impaired memory consolidation when administered during sleep but improved consolidation during the wake retention interval. Intrahippocampal infusion of GC or sleep/wake manipulations did not alter novel-object recognition performance that does not require the hippocampus. This work corroborates the notion of distinct consolidation processes occurring in sleep and wakefulnesss, and identifies GCs as a key player controlling distinct hippocampal memory consolidation processes in sleep and wake conditions. © 2014 Wiley Periodicals, Inc.