Get access

Postnatal development of the hippocampus in the Rhesus macaque (Macaca mulatta): A longitudinal magnetic resonance imaging study

Authors

  • Michael R. Hunsaker,

    1. Department of Psychiatry and Behavioral Sciences, UC Davis Medical Center, Sacramento, California
    2. The MIND Institute, UC Davis Medical Center, Sacramento, California
    Current affiliation:
    1. Department of Psychology, University of Utah, Salt Lake City, UT
    Search for more papers by this author
  • Julia A. Scott,

    1. Department of Psychiatry and Behavioral Sciences, UC Davis Medical Center, Sacramento, California
    2. Program in Neuroscience, UC Davis MIND Institute, Sacramento, California
    Search for more papers by this author
  • Melissa D. Bauman,

    1. Department of Psychiatry and Behavioral Sciences, UC Davis Medical Center, Sacramento, California
    2. The MIND Institute, UC Davis Medical Center, Sacramento, California
    3. California National Primate Research Center, UC Davis MIND Institute, Sacramento, California
    Search for more papers by this author
  • Cynthia M. Schumann,

    1. Department of Psychiatry and Behavioral Sciences, UC Davis Medical Center, Sacramento, California
    2. The MIND Institute, UC Davis Medical Center, Sacramento, California
    Search for more papers by this author
  • David G. Amaral

    Corresponding author
    1. Department of Psychiatry and Behavioral Sciences, UC Davis Medical Center, Sacramento, California
    2. The MIND Institute, UC Davis Medical Center, Sacramento, California
    3. California National Primate Research Center, UC Davis MIND Institute, Sacramento, California
    • Correspondence to: David G. Amaral, Department of Psychiatry and Behavioral Sciences, UC Davis MIND Institute, 2825 50th St., Sacramento, CA 95817, USA. E-mail: dgamaral@ucdavis.edu

    Search for more papers by this author

ABSTRACT

Nonhuman primates are widely used models to investigate the neural substrates of human behavior, including the development of higher cognitive and affective function. Due to their neuroanatomical and behavioral homologies with humans, the rhesus macaque monkey (Macaca mulatta) provides an excellent animal model in which to characterize the maturation of brain structures from birth through adulthood and into senescence. To evaluate hippocampal development in rhesus macaques, structural magnetic resonance imaging scans were obtained longitudinally at 9 time points between 1 week and 260 weeks (5 years) of age on 24 rhesus macaque monkeys (12 males, 12 females). In our sample, the hippocampus reaches 50% of its adult volume by 13 weeks of age and reaches an adult volume by 52 weeks in both males and females. The hippocampus appears to be slightly larger at 3 years than at 5 years of age. Male rhesus macaques have larger hippocampi than females from 8 weeks onward by approximately 5%. Interestingly, there was increased variability in hemispheric asymmetry for hippocampus volumes at younger ages than at later ages. These data provide a comprehensive evaluation of the longitudinal development of male and female rhesus macaque hippocampus across development from 1 week to 5 years of age. © 2014 Wiley Periodicals, Inc.

Ancillary