Research Article

Stereoselective Synthesis of Tetrahydrofuran Spiro-β-Lactams by Ru-Catalyzed Metathesis of 7-Oxabicyclo[2.2.1]heptenes

  1. Aurelio G. Csákÿ,
  2. Rocío Medel,
  3. M. Carmen Murcia,
  4. Joaquín Plumet

Article first published online: 21 JUN 2005

DOI: 10.1002/hlca.200590111

Issue

Helvetica Chimica Acta

Helvetica Chimica Acta

Volume 88, Issue 6, pages 1387–1396, June 2005

Additional Information

How to Cite

Csákÿ, A., Medel, R., Murcia, M. and Plumet, J. (2005), Stereoselective Synthesis of Tetrahydrofuran Spiro-β-Lactams by Ru-Catalyzed Metathesis of 7-Oxabicyclo[2.2.1]heptenes. Helvetica Chimica Acta, 88: 1387–1396. doi: 10.1002/hlca.200590111

Author Information

  1. Universidad Complutense, Facultad de Química, Departamento de Química Orgánica, E-28040 Madrid

Publication History

  1. Issue published online: 21 JUN 2005
  2. Article first published online: 21 JUN 2005
  3. Manuscript Received: 7 FEB 2005

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Abstract

A new method for the synthesis of spiro-β-lactams tethered to tetrahydrofuran rings is described. The procedure is based on Ru-catalyzed metathesis sequences with oxanorbornene precursors easily obtained by the Staudinger [2+2] cycloaddition of related imines.

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