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Keywords:

  • Tröger's base;
  • Enantiomer separations;
  • Supramolecular chemistry

Abstract

Thumbnail image of graphical abstract

Tröger's base is a well-known chiral molecule with a few unusual structural features. The chemistry of Tröger's base analogues has been greatly developed over the last 20 years, and numerous interesting applications in supramolecular chemistry and in molecular recognition have emerged. This Review gives a short overview of the chemistry of Tröger's base and its analogues, with particular focus on recent achievements in synthesis, enantiomer separations, and applications.