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Keywords:

  • β2-Homoselenocysteine;
  • Solution peptide synthesis;
  • Solid-phase peptide synthesis;
  • Amino acids;
  • Peptides

Abstract

Fmoc-β2hSer(tBu)-OH was converted to Fmoc-β2hSec(PMB)-OH in five steps. To avoid elimination of HSeR, the selenyl group was introduced in the second last step (Fmoc2hSer(Ts)-OAll[RIGHTWARDS ARROW]Fmoc-β2hSec(PMB)-OAll). In a similar way, the N-Boc-protected compound was prepared. With the β2hSe-derivatives, 21 β2-amino-acid building blocks with proteinogenic side chains are now available for peptide synthesis.