Xestospongienols A–L, Brominated Acetylenic Acids from the Chinese Marine Sponge Xestospongia testudinaria



Chemical examination of the Chinese marine sponge Xestospongia testudinaria resulted in the isolation and characterization of twelve new brominated acetylenic acids, namely xestospongienols A–L (1a1d, 2a2d, and 3a3d), together with the known analog 4. The structures of xestospongienols A–L were determined on the basis of 1D- and 2D-NMR, IR, and MS analysis in association with the modified Mosher method. The structural patterns are characteristic of brominated unbranched C16-alkyl chains containing polyene and acetylene moieties.