Facile Knoevenagel and Domino Knoevenagel/Michael Reactions Using Gel-Entrapped Base Catalysts

Authors

  • Shital Shinde,

    1. Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
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  • Gajanan Rashinkar,

    1. Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
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  • Arjun Kumbhar,

    1. Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
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  • Santosh Kamble,

    1. Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
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  • Rajashri Salunkhe

    Corresponding author
    1. Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
    • Department of Chemistry, Shivaji University, Kolhapur, 416004, M.S., India, (phone: +91 231 2609169; fax: +91 231 2692333)
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Abstract

An efficient method for Knoevenagel condensation of arenecarbaldehydes with active methylene compounds such as barbituric acid and Meldrum's acid in the presence of gel-entrapped base catalysts is reported. The method has been extended to the one-pot synthesis of arylmethylene-bis[3-hydroxycyclohex-2-en-1-one] derivatives from dimedone (=5,5-dimethylcyclohexane-1,3-dione) and arenecarbaldehydes by using domino Knoevenagel/Michael reaction sequence.

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