Microwave-Assisted Synthesis of β-Lactams and Cyclo-β-dipeptides

Authors

  • Luis G. Hernández-Vázquez,

    1. Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad No. 1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Mor., México
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  • Marco A. Leyva,

    1. Cinvestav-I.P.N., Departamento de Química, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07000, México D.F., México
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  • Alejandro J. Metta-Magaña,

    1. Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968-0513, USA
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  • Jaime Escalante

    Corresponding author
    1. Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad No. 1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Mor., México
    • Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad No. 1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Mor., México

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Abstract

Different cyclo-β-dipeptides were prepared from corresponding N-substituted β-alanine derivatives under mild conditions using PhPOCl2 as activating agent in benzene and Et3N as base. To evaluate β3-substituent influence, the amino acids 726 were synthesized, and a β-lactam formation reaction was carried out instead of cyclo-β-dipeptide formation. The crystal structures of three derivatives of cyclo-β-peptides and one β-lactam are presented.

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