Long-term survival of a child with refractory anaplastic large cell lymphoma following therapy with an antisense oligonucleotide, topotecan, and vinblastine

Authors

  • Grazyna Wrobel,

    Corresponding author
    1. Department of Bone Marrow Transplantation, Children Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland
    • Correspondence to: Grazyna Wrobel, Department of Bone Marrow Transplantation, Children Oncology and Haematology, 50–345 Wroclaw, 44 Bujwida St, Wroclaw, Poland

      E-mail: wrobel.wroc@wp.pl

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  • Radosław Chaber,

    1. Department of Bone Marrow Transplantation, Children Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland
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  • Jolanta Rygier,

    1. Cytogenetics Laboratory, Maria-Sklodowska Memory Cancer Center and Institute of Oncology, Warsaw, Poland
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  • Jolanta Bonar,

    1. Department of Bone Marrow Transplantation, Children Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland
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  • Katarzyna Muszynska-Roslan,

    1. Department of Paediatric Oncology and Haematology, Medical University of Bialystok, Bialystok, Poland
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  • Alicja Chybicka

    1. Department of Bone Marrow Transplantation, Children Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland
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  • Statement of prior presentation: This work was reported in part in poster form at the III World Asthma & COPD Forum and the World Forum of Pediatrics, Dubai, UAE, 24–27 April 2010.

Abstract

Anaplastic large cell lymphoma includes a subset of highly aggressive tumours and has a relapse rate of 30% at 2 years. Relapsed patients often have poor clinical outcome. The use of antisense oligonucleotides to down-regulate Bcl-2 protein can reverse chemotherapy resistance. The authors describe an 11-year-old boy with recurrent anaplastic large cell lymphoma who had received double high-dose chemotherapy followed by autologous haematopoietic stem-cell transplantation, had refractory disease and then had achieved long-term remission with the use of an antisense oligonucleotides in combination with vinblastine and topotecan. Copyright © 2011 John Wiley & Sons, Ltd.

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