Original Research Article

Double-delayed intensification paediatric protocol without radiotherapy is an efficient treatment in adult lymphoblastic lymphoma

  1. Elise Corre,
  2. Zora Marjanovic,
  3. Simona Lapusan,
  4. Anne Vekhoff,
  5. Pierre Hirsch,
  6. Jean-Pierre Marie,
  7. Ollivier Legrand*

Article first published online: 23 JAN 2012

DOI: 10.1002/hon.2007

Additional Information

How to Cite

Corre, E., Marjanovic, Z., Lapusan, S., Vekhoff, A., Hirsch, P., Marie, J.-P. and Legrand, O. (2012), Double-delayed intensification paediatric protocol without radiotherapy is an efficient treatment in adult lymphoblastic lymphoma. Hematol. Oncol.. doi: 10.1002/hon.2007

Author Information

  1. Département d'hématologie, Hôpital Saint-Antoine, APHP and Université Pierre et Marie Curie, Paris, France

*Ollivier Legrand, MD, PhD, Département d'hématologie, Hôpital Saint-Antoine, APHP and Université Pierre et Marie Curie, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, France.
E-mail: ollivier.legrand@sat.aphp.fr

Publication History

  1. Article first published online: 23 JAN 2012
  2. Manuscript Accepted: 23 DEC 2011
  3. Manuscript Revised: 16 DEC 2011
  4. Manuscript Received: 19 OCT 2011

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Keywords:

  • lymphoblastic lymphoma;
  • adult;
  • paediatric protocol;
  • pilot study

Abstract

Lymphoblastic lymphoma (LBL) is a rare disease associated with favourable prognosis in childhood but with poor prognosis in adults when treated with conventional non-Hodgkin lymphoma regimens. Improvements in long-term outcome have been made since the use of acute lymphoblastic leukaemia (ALL) regimens. We report here the feasibility of a double-delayed intensification paediatric protocol in 12 adult LBL patients. There were no relapses and no deaths, with a median follow-up of 4.7 years. Using the same protocol, overall survival was significantly longer in LBL patients versus ALL patients (100% vs 75%, p = 0.05). Overall tolerance was acceptable and better in ALL patients. We have shown the feasibility and the good results of using this paediatric protocol in LBL. Copyright © 2012 John Wiley & Sons, Ltd.

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