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Supporting information may be found in the online version of this article

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hon_2028_sm_f1.tifTIFF image1726KFigure S1. Time to second treatment (TTST) and survival from therapy (SFT) according to response to initial treatment. (A) Time to second treatment. Patients with a complete response to initial treatment show a better TTST (74% at 3 years) than patients with partial response (44% at 3 years) or nonresponders (40% and 19% at 3 years for patients with stable and progressive disease, respectively; p = 0.015). Number of cases, events, median TTST and 3-year TTST (%) were reported in the supporting information tables. A log-rank test was used for comparison between subsets. (B) Survival from first therapy. Patients with a complete response to initial treatment show a better survival (91% at 5 years) than patients with partial response (67% at 5 years) or nonresponders (66% and 45% at 5 years for patients with stable and progressive disease, respectively; p = 0.044). Number of cases, events, median SFT and 5-year SFT (%) were reported in the supporting information tables. Log-rank test was used for comparison between subsets.
hon_2028_sm_f2.tifTIFF image2434KFigure S2. Kaplan–Meier curves for OS in 131 CLL patients with 11q deletion. Patients are stratified accordingly to age (A), Binet risk (B), CD38 expression (C), β2-microglobulin level (D), abdominal lymphadenopathy (E) and splenomegaly (F). Number of cases, events, median OS and 10-year OS (%) were reported in the supporting information tables. Log-rank test was used for comparison between subsets.
hon_2028_sm_f3.tifTIFF image905KFigure S3. Kaplan–Meir curves of OS in CLL subset not treated with FC/FCR regiments in first-line therapy. Patients are stratified accordingly to percentage of 11q deleted nuclei by using a cut-off point equal to 25%. Note the inferior OS (median = 116 months) for patients with high % 11q- nuclei compared with low subset (median OS not reached; p = 0.08, log-rank test).
hon_2028_sm_tables.docWord document74KSupporting Information

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