13-ICML President
- F. Cavalli, Bellinzona (Switzerland)
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Remove maintenance messageSAVE THE DATE: 14-ICML – 14th International Conference on Malignant Lymphoma
Lugano, Switzerland
June 14-17, 2017
| 12:00 to 14:00 (room B I) | AMGEN (EUROPE) GmbH |
| NOVEL APPROACHES TO LYMPHOMA AND LEUKEMIA: ENGAGING THE T-CELL WITH BISPECIFIC ANTIBODY CONSTRUCTS | |
| Chair: M. Ghielmini, Bellinzona (Switzerland) | |
| 15:30 to 17:30 (room B I) | NOVARTIS ONCOLOGY |
| MORE EVIDENCE, MORE OPTIONS: FIRST-LINE TREATMENT OF CLL | |
| Chair: K. Stamatopoulos, Thessaloniki (Greece) | |
| 15:30 to 17:30 (room B II) | CTI LIFE SCIENCES LIMITED and SERVIER |
| CHANGING EXPECTATIONS IN THE TREATMENT OF RELAPSED AND REFRACTORY AGGRESSIVE NHL | |
| Chair: M. Ghielmini, Bellinzona (Switzerland) | |
| 19:00 to 21:00 (room A) | BRISTOL-MYERS SQUIBB |
| IMMUNO-ONCOLOGY: A NEW ERA IN HEMATOLOGY TREATMENT? EMERGING RESEARCH IN LYMPHOMA AND MYELOMA | |
| Chair: A. Engert, Cologne (Germany) | |
| 19:00 to 21:00 (room B I) | BAYER HEALTHCARE PHARMACEUTICALS, Inc. |
| THE EVOLVING THERAPEUTIC POTENTIAL OF PI3K INHIBITORS IN RELAPSED OR REFRACTORY NON-HODGKIN'S LYMPHOMA | |
| Chair: M. Ghielmini, Bellinzona (Switzerland) | |
| 19:00 to 21:00 (room B II) | TAKEDA ONCOLOGY, SEATTLE GENETICS, Inc., THE LEUKEMIA LYMPHOMA SOCIETY and MEDICOM WORLDWIDE, Inc. |
| CONTEMPORARY THERAPY FOR HODGKIN LYMPHOMA: WHERE ARE WE NOW? | |
| Chair: F. Cavalli, Bellinzona (Switzerland) |
| 19:00 to 21:00 (room A) | JANSSEN PHARMACEUTICAL COMPANIES OF JOHNSON & JOHNSON |
| CHALLENGING THE PARADIGMS IN B-CELL MALIGNANCIES | |
| Co-chairs: M. Dreyling, Munich (Germany) and S. Rule, Plymouth (UK) | |
| 19:00 to 21:00 (room B) | GILEAD SCIENCES EUROPE, Ltd. |
| NEW OPTIONS AND EVOLVING STRATEGIES IN THE MANAGEMENT OF HEMATOLOGICAL MALIGNANCIES | |
| Co-Chairs: M. Hallek, Cologne (Germany) and G. Salles, Lyon (France) |
| 19:00 to 21:00 (room A) | CELGENE CORPORATION |
| IMMUNE-BASED STRATEGIES TOWARDS ADVANCING THE TREATMENT OF B-CELL MALIGNANCIES | |
| Chair: F. Cavalli, Bellinzona (Switzerland) | |
| 19:00 to 21:00 (room B) | |
| MUNDIPHARMA ONCOLOGY | |
| CLL AND FOLLICULAR NHL: CRITICAL REVIEW OF THE CURRENT GUIDELINES AND FUTURE PERSPECTIVES | |
| Co-chairs: J.G. Gribben, London (UK) and M. Ghielmini, Bellinzona (Switzerland) |
| 18:45 to 19:45 (room A) |
| ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND – IOSI |
| Supported by an unrestricted educational grant by GILEAD SCIENCES EUROPE, Ltd. |
| THE BIG DEBATE: SHOULD WE ALWAYS AIM AT MINIMAL RESIDUAL DISEASE ERADICATION? |
| Chair: M. Ghielmini, Bellinzona (Switzerland) |
| 09:30–17:30 Auditorium, University Campus | Closed workshop: ‘follicular lymphoma: recent insights and future directions (moving towards biology-driven treatments?)’* |
| Co-Chairs: R.D. Gascoyne, Vancouver, BC (Canada) and E. Zucca, Bellinzona (Switzerland) | |
| Supported by American Association for Cancer Research – AACR and European School of Oncology – ESO | |
| *by invitation only | |
| 15:00–18:00 | workshop on radiotherapy for lymphoma: ‘controversies in the use of radiation therapy for advanced stage lymphoma’** |
| Cinema Corso | Co-Chairs: D. Hodgson, Toronto, ON (Canada) and T. Illidge, Manchester (UK) |
| Organized by International Lymphoma Radiation Oncology Group – ILROG | |
| **open to all 13-ICML attendees |
| 08:30–12:00 | POSTER SESSION SET UP (Marquee Parco Ciani) | |
| 08:30–09:15 5 parallel sessions | Article number | ‘MEET THE PROFESSOR’ SESSIONS |
| Room A | IV. | Masses in the mediastinum: primary mediastinal lymphoma and intermediate types |
| P.M.W. Johnson, Southampton (UK) | ||
| repeated on Thursday, June 18, in Auditorium, University Campus | ||
| Room B | VII. | Are lymphomas driven by epigenetic lesions? A.M. Melnick, New York, NY (USA) |
| repeated at 09:30 in Cinema Corso | ||
| Cinema Corso | X. | Challenges and future directions in peripheral t-cell lymphoma |
| K.J. Savage, Vancouver, British Columbia (Canada) | ||
| repeated at 09:30 in Room B | ||
| Auditorium, University Campus | III. | Current concepts in primary central nervous lymphoma |
| G. Illerhaus, Stuttgart (Germany) | ||
| repeated on Thursday, June 18, in Cinema Corso | ||
| Aula Magna, University Campus | IX. | Is it only about myc? how to approach the diagnosis of diffuse large b-cell lymphomas |
| L. Quintanilla-Martinez, Tuebingen (Germany) | ||
| repeated on Friday, June 19, in Cinema Corso | ||
| 09:30–10:15 5 parallel sessions | ||
| Room A | VIII. | Treatment of cll, where are we heading? |
| S.M. O'Brien, Irvine, CA (USA) | ||
| repeated on Friday, June 19, in Auditorium, University Campus | ||
| Room B | X. | Challenges and future directions in peripheral t-cell lymphoma |
| K.J. Savage, Vancouver, BC (Canada) | ||
| Cinema Corso | VII. | Are lymphomas driven by epigenetic lesions? |
| A.M. Melnick, New York, NY (USA) | ||
| Auditorium, University Campus | XII. | Therapeutic exploitation of autologous t-cell activation in b-cell lymphoma |
| A. Younes, New York, NY (USA) | ||
| repeated on Thursday, June 18, in Room A | ||
| Aula Magna, University Campus | VI. | FDG-pet as a biomarker in lymphoma: from qualitative to quantitative analysis |
| M. Meignan, Creteil (France) | ||
| repeated on Friday, June 19, in Aula Magna, University Campus | ||
| 10:15–10:35 | COFFEE BREAK (Marquee Parco Ciani) | |
| 10:35–12:00 2 parallel sessions | EDUCATIONAL SYMPOSIA | |
| Room A – Marquee (overflow area) | HISTOLOGICAL TRANSFORMATION IN LYMPHOMA: CLINICAL, PATHOLOGICAL AND MOLECULAR FEATURES | |
| Chair: J.G. Gribben, London (UK) | ||
| LECTURES: | ||
| XIII. | Molecular pathogenesis of transformed lymphomas | |
| D. Rossi, Novara (Italy) | ||
| XIV. | The pathology of transformation of lymphoma | |
| R.D. Gascoyne, Vancouver, BC (Canada) | ||
| XV. | Clinical aspects of transformed lymphoma | |
| J.G. Gribben, London (UK) | ||
| Room B | Hodgkin lymphoma – challenges and opportunities | |
| Chair: R.H. Advani, Stanford, CA (USA) | ||
| LECTURES: | ||
| XVI. | Early stage hodgkin lymphoma | |
| J.A. Radford, Manchester (UK) | ||
| XVII. | Treatment of advanced-stage hodgkin lymphoma | |
| A. Engert, Cologne (Germany) | ||
| XVIII. | Management of nodular lymphocyte predominant hodgkin lymphoma | |
| R.H. Advani, Stanford, CA (USA) | ||
| 12:00–18:30 Marquee | Abstract number | POSTER SESSION |
| (printing of the posters sponsored by Takeda Oncology) | ||
| 148–170 | Pathology and biology | |
| 171–181 | Hodgkin lymphoma | |
| 182–186 | CLL | |
| 187–201 | Indolent lymphoma | |
| 202–209 | Mantle cell lymphoma | |
| 210–224 | Aggressive b-cell lymphoma | |
| 225–230 | Extranodal lymphoma | |
| 231–250 | T-Cell lymphoma | |
| 251–259 | Imaging | |
| 260–279 | Pre-clinical studies | |
| 280–287 | Early clinical trials | |
| OT07–OT15 | Ongoing trials | |
| 12:00–13:00 Marquee | LUNCH TIME AND POSTER VIEWING | |
| 13:00–14:00 Room A, B and Marquee (overflow area) | OPENING OF THE CONFERENCE | |
| Welcome and introductory remarks | ||
| F. Cavalli, Bellinzona (Switzerland) | ||
| Henry kaplan memorial lecture and san salvatore foundation award | ||
| Introduction to San Salvatore Foundation: L. Butti, Lugano (Switzerland) | ||
| Laudatio: R. Stahel, Zurich (Switzerland) | ||
| 001 | Therapy of lymphoma inspired by functional and structural genomics | |
| L.M. Staudt, Bethesda, MD (USA) | ||
| 14:00–15:15 Room A, B and Marquee (overflow area) | PLENARY SESSION | |
| Co-Chairs: G.P. Canellos, Boston, MA (USA) and J.W. Friedberg, Rochester, NY (USA) | ||
| 14:00 | 008 | Response-adapted therapy based on interim fdg-pet scans in advanced hodgkin lymphoma: first analysis of the safety of de-escalation and efficacy of escalation in the international rathl study (CRUK/07/033) |
| P.M.W. Johnson, Southampton (UK) | ||
| 14:15 | Discussant: A. Engert, Cologne (Germany) | |
| 14:25 | 009 | Addition of thiotepa and rituximab to antimetabolites significantly improves outcome in primary cns lymphoma: first randomization of the IELSG32 trial |
| A.J. Ferreri, Milan (Italy) | ||
| 14:40 | Discussant: T.T. Batchelor, Boston, MA (USA) | |
| 14:50 | 010 | Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical hodgkin lymphoma: updated results of a Phase 1 study (CA209-039) |
| J. Timmerman, Los Angeles, CA (USA) | ||
| 15:05 | Discussant: A. Younes, New York, NY (USA) | |
| 15:15–15:40 Marquee | COFFEE BREAK | |
| 15:40–16:40 Room A, B and Marquee (overflow area) | AACR-ICML JOINT SESSION: SPECIAL LECTURES | |
| Co-Chairs: F. Cavalli, Bellinzona (Switzerland) and M. Foti, Philadelphia, PA (USA) | ||
| 15:40 | 004 | Update on the revision of the who lymphoma classification |
| S.H. Swerdlow, Pittsburgh, PA (USA) | ||
| 16:10 | 005 | What's new in multiple myeloma? |
| S.V. Rajkumar, Rochester, MN (USA) | ||
| 16:40–17:15 | BREAK | |
| 17:15–18:15 6 parallel sessions | ‘FOCUS ON…’ SESSIONS | |
| Room A | IMIDs in lymphoma | |
| Chair: N. Fowler, Houston, TX (USA) | ||
| 17:15 | 011 | Independent review of ct responses in the trial SAKK35/10 comparing rituximab with or without lenalidomide in untreated FL patients in need of therapy |
| E. Zucca, Bellinzona (Switzerland) | ||
| 17:25 | 012 | Rituximab+Lenalidomide in malt lymphoma: final results |
| M. Raderer, Vienna (Austria) | ||
| 17:35 | 013 | Lenalidomide added to bendamustine-rituximab for untreated chronic lymphocytic leukemia (CLL): a Phase 1 study |
| J.S. Abramson, Boston, MA (USA) | ||
| 17:45 | 014 | Rituximab, lenalidomide, bendamustine second line therapy in mantle cell lymphoma: A Phase II study of the fondazione italiana linfomi (FIL) |
| F. Zaja, Udine (Italy) | ||
| 17:55 | 015 | Rituximab, bendamustine and lenalidomide in patients with relapsed/refractory aggressive b-cell lymphoma not eligible for salvage chemotherapy. Phase II trial – SAKK 38/08 |
| F. Hitz, St. Gallen (Switzerland) | ||
| 18:05 | 016 | A Phase I/II trial of the combination of romidepsin and lenalidomide in patients with relapsed/refractory lymphoma and myeloma |
| N. Mehta-Shah, New York, NY (USA) | ||
| Room B | Genomic alterations | |
| Chair: G. Gaidano, Novara (Italy) | ||
| 17:15 | 017 | Sequence-based panomics analyses by the ICGC MMML-SEQ deciphers multi-layer pathway deregulation in germinal center derived B-cell lymphomas |
| R. Siebert, Kiel (Germany) | ||
| 17:25 | 018 | Structural variants in germinal-center derived B-cell lymphomas: analyses in the framework of the ICGC MMML-SEQ porject |
| C. Lopez, Kiel (Germany) | ||
| 17:35 | 019 | Comprehensive genomic profiling of diffuse large B-cell lymphoma in the clinical setting |
| J. He, Cambridge, MA (USA) | ||
| 17:45 | 020 | Targeted genomic sequencing prospectively identifies clinically relevant genetic alterations across lymphoma subtypes |
| C.L. Batlevi, New York, NY (USA) | ||
| 17:55 | 021 | Posttransplant diffuse large B-cell lymphoma and burkitt lymphoma: new genetic findings |
| I. Wlodarska, Leuven (Belgium) | ||
| 18:05 | 022 | Microrna-150 influences microenvironmental interactions and prognosis of follicular lymphoma |
| M. Mraz, Brno (Czech Republic) | ||
| Room C | Clinicopathological correlations | |
| Chair: M.A. Piris, Santander (Spain) | ||
| 17:15 | 023 | Frequencies of lymphoma entities and impact of diagnostic review: a french experience on 35.753 lymphomas over 2010–2013 |
| C. Laurent, Toulouse (France) | ||
| 17:25 | 024 | Rituximab treatment in follicular lymphoma circumvents the prognostic value of intra-tumoral t-cells: automated image analysis of the lysa prima trial |
| L. Xerri, Marseille (France) | ||
| 17:35 | 025 | Cell of origin (COO) assignment in transformed follicular lymphoma |
| R. Kridel, Vancouver, British Columbia (Canada) | ||
| 17:45 | 026 | NOTCH1/2 mutations are recurrently found in cyclin D1-negative SOX11-positive mantle cell lymphoma |
| I. Salaverria, Barcelona (Spain) | ||
| 17:55 | 027 | Clinicopathological study of HHV8-negative body cavity-based lymphoma (BCBL) |
| D. Kaji, Tokyo (Japan) | ||
| 18:05 | 028 | Grey zone lymphoma between classical hodgkin lymphoma and diffuse large B-cell lymphoma: a lysa retrospective analysis |
| C. Sarkozy, Pierre Bénite (France) | ||
| Cinema Corso | Transplantation | |
| Chair: S. Montoto, London (UK) | ||
| 17:15 | 029 | Beam plus rituximab or radioimmunotherapy versus beam for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma: a retrospective study of the LWP-EBMT |
| L. Bento, Paris (France) | ||
| 17:25 | 030 | Outcome of reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after a previous autologous stem cell transplant |
| S. Robinson, Bristol (UK) | ||
| 17:35 | 031 | A UK lymphoma clinical study group Phase II evaluation of high-dose chemotherapy and autologous stem cell transplantation in intestinal and other aggressive t-cell lymphomas |
| M.M. Lannon, Newcastle upon Tyne (UK) | ||
| 17:45 | 032 | Allogeneic transplantation for T-cell lymphomas: no difference in outcome between patients allografted up-front and in first chemosensitive relapse |
| A. Dodero, Milan (Italy) | ||
| 17:55 | 033 | Allogeneic or autologous transplantation as first-line therapy for younger patients with peripheral T-cell lymphoma – results of the interim analysis of the AATT trial |
| N. Schmitz, Hamburg (Germany) | ||
| 18:05 | 034 | Post transplant cyclophosphamide reduces non relapse mortality of haplo-identical transplants yielding similar outcomes as with matched sibling donors |
| S. Dietrich, Heidelberg (Germany) | ||
| Auditorium, University Campus | Novel agents | |
| Chair: G. Salles, Pierre Bénite (France) | ||
| 17:15 | 035 | Lipid addiction of DLBCL: involvement of PI3K signaling and potential therapeutic strategies via fatty acid synthase small molecule inhibitors |
| A. Evens, Boston, MA (USA) | ||
| 17:25 | 036 | EZH2 and MYD88 mutations appear associated with antitumor activity of three new bet bromodomain inhibitors (BAY-5627, BAY-7575 and BAY-8097) in preclinical lymphoma models |
| E. Bernasconi, Bellinzona (Switzerland) | ||
| 17:35 | 037 | Venetoclax (ABT-199/GDC-0199) monotherapy for relapsed/?refractory (r/r) multiple myeloma (MM): Phase 1 results |
| S. Heitner Enschede, Chicago, IL (USA) | ||
| 17:45 | 038 | TGR-1202, a novel once daily PI3Kδ inhibitor, demonstrates clinical activity with a favorable safety profile, lacking hepatotoxicity in patients with cll and B-cell lymphoma |
| H.A. Burris III, Nashville, TN (USA) | ||
| 17:55 | 039 | Ongoing, first-in-human, Phase 1 dose-escalation study of investigational SYK inhibitor TAK-659 in patients with advanced solid tumors or lymphoma |
| A.M. Petrich, Chicago, IL (USA) | ||
| 18:05 | 040 | ARGX-110, a novel monoclonal antibody targeting CD70, is associated with biological activity in patients with relapsed/?refractory T-cell lymphomas |
| M. Maerevoet, Villejuif (France) | ||
| Aula Magna, University Campus | Short- and long-term toxicity of lymphoma therapies | |
| Chair: M.F. Fey, Bern (Switzerland) | ||
| 17:15 | 041 | Pulmonary function and grade 3/4 clinical events in pet negative patients taking part in the international rathl trial (CRUK/07/033): a comparison of 12 vs 4 doses of bleomycin |
| C. Hague, Manchester (UK) | ||
| 17:25 | 042 | SYK & PI3K δ pathway inhibition resulted in increased rates of pneumonitis: implications for developing future small molecule combinations |
| P.M. Barr, Rochester, NY (USA) | ||
| 17:35 | 043 | Cardiovascular disease after therapy for hodgkin lymphoma: a detailed analysis of 9 collaborative eortc-LYSA trials |
| M. Maraldo, Copenhagen (Denmark) | ||
| 17:45 | 044 | A radiation dose-response relationship for risk of coronary heart disease in survivors of hodgkin lymphoma: a case-control study |
| B.M. Aleman, Amsterdam (The Netherlands) | ||
| 17:55 | 045 | Anticoagulant/antiplatelet therapy concomitant with idelalisib in chronic lymphocytic leukemia and indolent NHL: use and outcomes |
| P. Ghia, Milan (Italy) | ||
| 18:05 | 046 | Patterns of cognitive difficulties after treatment for lymphoma |
| O.C. Lindner, Manchester (UK) |
| 08:30–18:30 Marquee | POSTER SESSION | |
| 08:00–08:45 5 parallel sessions | Article number | ‘MEET THE PROFESSOR’ SESSIONS |
| Room A | XII. | Therapeutic exploitation of autologous T-cell activation in B-cell lymphoma |
| A. Younes, New York, NY (USA) | ||
| Room B | XI. | Management of pediatric and adult non hodgkin lymphoma: what lessons can each teach the other? |
| B. Burkhardt, Muenster (Germany) and J.F. Seymour, Melbourne (Australia) | ||
| Cinema Corso | III. | Current concepts in primary central nervous lymphoma |
| G. Illerhaus, Stuttgart (Germany) | ||
| Auditorium, University Campus | IV. | Masses in the mediastinum: primary mediastinal lymphoma and intermediate types |
| P.M.W. Johnson, Southampton (UK) | ||
| Aula Magna, University Campus | V. | Smoldering multiple myeloma |
| M.V. Mateos, Salamanca (Spain) | ||
| 09:00–10:35 Room A and Marquee (overflow area) | Abstract number | SESSION 1 – LYMPHOMA BIOLOGY AND GENOMICS I |
| Co-Chairs: R. Dalla-Favera, New York, NY (USA) and R.D. Gascoyne, Vancouver, British Columbia (Canada) | ||
| 09:00 | 047 | Introduction: Germinal centers and lymphomagenesis |
| R. Dalla-Favera, New York, NY (USA) | ||
| 09:20 | 048 | Whole exome sequencing of refractory aggressive B-cell lymphomas identified recurrent mutations of the exportin 1 gene (XPO1) in primary mediastinal B-cell lymphoma subtype. a LYSA study |
| F. Jardin, Rouen (France) | ||
| 09:35 | 049 | Recurrent somatic mutations in diffuse large b-cell lymphoma assessed by high-throughput targeted sequencing highlight molecular subtypes' genetic divergence: a LYSA study |
| S. Dubois, Rouen (France) | ||
| 09:50 | 050 | A modified autoantigen is the first molecularly defined risk factor and a dominant antigenic target / stimulus of the b-cell receptor from ABC-type DLBCL |
| M. Pfreundschuh, Homburg (Germany) | ||
| 10:05 | 051 | The role of tonic bcr signaling in a mouse model of MYC-driven lymphoma |
| S. Casola, Milan (Italy) | ||
| 10:20 | 052 | Recurrent mtorc1-activating RRAGC mutations are a feature of follicular lymphoma |
| J. Okosun, London (UK) | ||
| 09:00–10:30 5 parallel sessions | ‘CASE DISCUSSION’ SESSIONS | |
| Italian Lymphoma Foundation – FIL vs Cornell University and Memorial Sloan-Kettering Cancer Center in New York, NY (USA) | ||
| Room B | Indolent lymphoma | |
| Chair: A. Davies, Southampton (UK) | ||
| Discussants: L. Arcaini, Pavia (Italy) and J.P. Leonard, New York, NY (USA) | ||
| Room C | Pediatric and adolescent lymphoma | |
| Chair: W. Wössmann, Giessen (Germany) | ||
| Discussants: M. Pillon, Padua (Italy) and C.E. Allen, Houston, TX (USA) | ||
| Cinema Corso | CLL | |
| Chair: J.G. Gribben, London (UK) | ||
| Discussants: R. Foà, Rome (Italy) and A.D. Zelenetz, New York, NY (USA) | ||
| Auditorium, University Campus | T-cell lymphoma | |
| Chair: F. d'Amore, Aarhus (Denmark) | ||
| Discussants: P. Corradini, Milan (Italy) and S. Horwitz, New York, NY (USA) | ||
| Aula Magna, University Campus | Hodgkin lymphoma | |
| Chair: J.A. Radford, Manchester (UK) | ||
| Discussants: P.L. Zinzani, Bologna (Italy) and A. Younes, New York, NY (USA) | ||
| 10:35–11:00 Marquee | COFFEE BREAK | |
| 11:00–12:00 Room A, B and Marquee (overflow area) | SESSION 2 – ADVANCES IN CLL | |
| Co-Chairs: M. Hallek, Cologne (Germany) and A.D. Zelenetz, New York, NY (USA) | ||
| 11:00 | 053 | In-vivo studies of kinetics in chronic lymphocytic leukaemia provide definitive evidence of LYMPH-node re-entry and suggest that there is a non-proliferative sub-clone |
| K. Cuthill, London (UK) | ||
| 11:15 | 054 | The international prognostic index for patients with chronic lymphocytic leukemia (CLL-IPI) – an international meta-analysis |
| J. Bahlo, Cologne (Germany) | ||
| 11:30 | 055 | Efficacy of ibrutinib vs ofatumumab by cytogenetic and clinical subgroups in a Phase 3 trial in patients with previously treated CLL/SLL |
| P. Thornton, Dublin (Ireland) | ||
| 11:45 | 056 | BFR (bendamustine, fludarabine, rituximab) allogeneic conditioning improves survival in CLL |
| I.F. Khouri, Houston, TX (USA) | ||
| 12:00–13:00 Marquee | LUNCH TIME AND POSTER VIEWING | |
| from 12:30 to 13:00 authors in front of their posters for discussion with attendees | ||
| 13:00–13:45 Room A, B and Marquee (overflow area) | HENRY RAPPAPORT MEMORIAL LECTURE | |
| Chair: P. Gaulard, Créteil (France) | ||
| 002 | MANTLE CELL LYMPHOMA, AN UNFOLDING STORY FROM THE MICROSCOPE TO THE GENOME | |
| E. Campo, Barcelona (Spain) | ||
| 13:00–17:00 Cinema Corso | WORKSHOP FOR RADIATION ONCOLOGISTS | |
| Co-Chairs: M.K. Gospodarowicz, Toronto (Canada) and L. Specht, Copenhagen (Denmark) | ||
| Organized by International Lymphoma Radiation Oncology Group - ILROG | ||
| Part 1: Technical challenges in radiation therapy of lymphomas | ||
| B. Dabaja, Houston, TX (USA) | ||
| Part 2: Panel discussion: COMPETENCIES FOR RADIATION ONCOLOGISTS WITH SPECIAL EXPERTISE IN LYMPHOMAS | ||
| 13:45 – 15:15 Room A, B and Marquee (overflow area) | SESSION 3 – MANTLE CELL LYMPHOMA | |
| Co-Chairs: M. Dreyling, Munich (Germany) and P. Martin, New York, NY (USA) | ||
| 13:45 | 057 | PI3K INACTIVATION AND REDOX STRESS MEDIATES THERAPEUTIC TARGETING OF CDK4 IN MCL |
| S. Chen-Kiang, New York NY (USA) | ||
| 14:00 | 058 | PROGNOSTIC VALUE OF PROLIFERATION, CYTOLOGY, AND GROWTH PATTERN IN MANTLE CELL LYMPHOMA: RESULTS FROM RANDOMIZED TRIALS OF THE EUROPEAN MCL NETWORK |
| E. Hoster, Munich (Germany) | ||
| 14:15 | 059 | RITUXIMAB, BENDAMUSTINE AND CYTARABINE (RBAC500) AS INDUCTION THERAPY IN ELDERLY PATIENTS WITH MANTLE CELL LYMPHOMA: A PHASE 2 STUDY FROM THE FONDAZIONE ITALIANA LINFOMI |
| C. Visco, Vicenza (Italy) | ||
| 14:30 | 060 | LENALIDOMIDE-RITUXIMAB-BENDAMUSTINE IN FIRST LINE FOR PATIENTS > 65 WITH MANTLE CELL LYMPHOMA: FINAL RESULTS OF THE NORDIC LYMPHOMA GROUP MCL4 (LENA-BERIT) PHASE I/II TRIAL |
| A. Albertsson-Lindblad, Lund (Sweden) | ||
| 14:45 | 061 | RITUXIMAB MAINTENANCE VERSUS WW AFTER R-DHAP PLUS ASCT IN UNTREATED PATIENTS WITH MCL: INTERIM ANALYSIS OF THE LYMA TRIAL, A LYSA STUDY |
| S. Le Gouill, Nantes (France) | ||
| 15:00 | 062 | RESULTS OF A RANDOMIZED PHASE II TRIAL OF R-HCVAD VS. R-BENDAMUSTINE FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTS FOR PATIENTS WITH MANTLE CELL LYMPHOMA: US INTERGROUP S1106 |
| R. Chen, Duarte, CA (USA) | ||
| 14:45–16:55 | SESSION 4 - PEDIATRIC LYMPHOMA | |
| Room C | Chair: W. Wössmann, Giessen (Germany) | |
| 14:45 | 063 | Nodular lymphocyte predominant hodgkin lymphoma in children and adolescents: therapeutic approaches and grey zone to mature B-NHL |
| C. Mauz-Körholz, Halle (Germany) | ||
| 15:05 | 064 | New targets for the treatment of mature B-NHL |
| F. Jardin, Rouen (France) | ||
| 15:25–15:40 | COFFEE BREAK – Inside Room C for session 4 attendees | |
| 15:40 | 065 | Results of the randomized trial EURO-LB02 on lymphoblastic lymphoma in children and adolescents – a report of the European intergroup for childhood non-hodgkin lymphoma |
| B. Burkhardt, Muenster (Germany) | ||
| 15:55 | 066 | Relapses in children/adolescents with mature B-cell lymphoma/leukemia treated in the rituximab era – a study of the Société Française des Cancers de L'enfant |
| V. Minard-Colin, Villejuif (France) | ||
| 16:10 | 067 | Treatment and characterization of patients with Burkitt Lymphoma (BL): Results from a single institution in Northern Uganda |
| V. Calbi, Gulu (Uganda) | ||
| 16:25 | 068 | Risk-adapted approach for patients with relapsed or refractory ALCL – final report of the prospective ALCL-relapse trial of the EICNHL |
| S. Ruf, Giessen (Germany) | ||
| 16:40 | 069 | Lymphoma associated with a constitutional mismatch repair deficiency syndrome: clinical description in a french cohort |
| N. Lavoine, Villejuif (France) | ||
| 15:15–15:35 Marquee | COFFEE BREAK | |
| 15:35–17:05Room A and Marquee (overflow area) | SESSION 5 – T-CELL LYMPHOMA | |
| Co-Chairs: K. Tobinai, Tokyo (Japan) and J.M. Vose, Omaha, NE (USA) | ||
| 15:35 | 070 | T-cell project: an international, prospective, observational study of patients with aggressive peripheral NK/T-cell lymphoma. lesson from the first 1308 patients |
| M. Federico, Modena (Italy) | ||
| 15:50 | 071 | The genetic landscape of hepatosplenic T-cell lymphoma reveals novel strategies for treatment and risk-stratification |
| P. Gaulard, Créteil (France) | ||
| 16:05 | 072 | A PTCL, NOS subset with molecular and clinical features similar to AITL |
| M. Dobay, Lausanne (Switzerland) | ||
| 16:20 | 073 | Radiation therapy for primary cutaneous anaplastic large cell lymphoma (pcALCL): an international lymphoma radiation oncology group (ILROG) multi-institutional experience |
| R.T. Hoppe, Stanford, CA (USA) | ||
| 16:35 | 074 | Ten years median follow-up of the Nordic NLG-T-01 trial on choep and upfront autologous transplantation in peripheral T-cell lymphomas |
| F. d'Amore, Aarhus (Denmark) | ||
| 16:50 | 075 | 5-year follow-up of the smile Phase II study for newly-diagnosed Stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type |
| R. Suzuki, Izumo (Japan) | ||
| 15:35–16:55 | SESSION 6 – INTERFERING WITH BCR-NFKB PATHWAYS | |
| Room B | Co-Chairs: M.A. Shipp, Boston, MA (USA) and F.E. Cotter, London (UK) | |
| 15:35 | 076 | Introduction: BCR SIGNALING AND SURVIVAL PATHWAYS IN LYMPHOMA |
| M.A Shipp, Boston, MA (USA) | ||
| 15:55 | 077 | Ibrutinib is highly active and produces durable responses in previously treated waldenström's macroglobulinemia |
| S. Treon, Boston, MA (USA) | ||
| 16:10 | 078 | The novel dual PI3K/MTOR inhibitor PQR309 shows preclinical activity as single agent or in combination and targets central signaling pathways in B-cell lymphomas |
| C. Tarantelli, Bellinzona (Switzerland) | ||
| 16:25 | 079 | Phase 1 study of PI3Kδ inhibitor INCB040093 alone or in combination with selective JAK1 inhibitor INCB039110 in patients with relapsed/refractory B-cell malignancies |
| T.J. Phillips, Ann Arbor, MI (USA) | ||
| 16:40 | 080 | A first-in-human trial of CUDC-907, an oral, first-in-class, dual inhibitor of PI3K and HDAC, in patients with refractory/relapsed lymphoma and multiple myeloma |
| A. Younes, New York, NY (USA) | ||
| 17:15–18:15 6 parallel sessions | ‘FOCUS ON…’ SESSIONS | |
| Room A | Imaging | |
| Chair: B.D. Cheson, Washington, DC (USA) | ||
| 17:15 | 081 | Use of the lugano classification criteria for PET/CT assessment of primary mediastinal B-CELL lymphoma after immunochemotherapy and irradiation in the IELSG-26 study |
| L. Ceriani, Bellinzona (Switzerland) | ||
| 17:25 | 082 | PET score following 3 cycles ABVD has greater prognostic value than pre-treatment risk stratification in the rapid trial in early stage hodgkin lymphoma (HL) |
| J. Radford, Manchester (UK) | ||
| 17:35 | 083 | Baseline total metabolic volume (TMTV0) predicts the outcome of patients with diffuse large B-cell lymphoma (DLBCL) enrolled in the LNH07-3B LYSA trial |
| O. Casasnovas, Créteil (France) | ||
| 17:45 | 084 | Prognostic value of baseline total metabolic tumour volume (TMTV0) measured on FDG-PET/CT in patients with peripheral T-cell lymphoma (PTCL) |
| A. Cottereau, Rouen (France) | ||
| 17:55 | 085 | Little value of routine surveillance imaging for primary CNS lymphomas in first remission: results from a danish multicenter study |
| K. Juul Mylam, Odense (Denmark) | ||
| 18:05 | 086 | Routine imaging for diffuse large B-CELL lymphoma in first remission is not associated with better survival: a danish–swedish population-based study |
| T.C. El-Galaly, Aalborg (Denmark) | ||
| Room B | Targetting CD30 | |
| Chair: P. Borchmann, Cologne (Germany) | ||
| 17:15 | 087 | Brentuximab vedotin plus AVD for non-bulky limited stage classical hodgkin lymphoma: a Phase 2 trial |
| J.S. Abramson, Boston, MA (USA) | ||
| 17:25 | 088 | Preliminary efficacy and safety of brentuximab vedotin and AVD chemotherapy followed by involved-site radiotherapy in early stage, unfavorable risk hodgkin lymphoma |
| A. Kumar, New York, NY (USA) | ||
| 17:35 | 089 | Sequential brentuximab vedotin and AVD for older hodgkin lymphoma patients: initial results from a Phase 2 multicenter study |
| A.M. Evens, Boston, MA (USA) | ||
| 17:45 | 090 | A Phase 1 study of brentuximab vedotin (BV) and bendamustine (B) in relapsed or refractory hodgkin lymphoma (HL) and anaplastic large T-cell lymphoma (ALCL) |
| J. Kuruvilla, Toronto, ON (Canada) | ||
| 17:55 | 091 | Brentuximab vedotin demonstrates antitumor activity in CD30+ DLBCL |
| M.R. Smith, Boston, MA (USA) | ||
| 18:05 | 092 | Updated results of a Phase 2 trial of brentuximab vedotin combined with RCHOP in frontline treatment of pts with high-intermediate/high-risk DLBCL |
| S.M. Ansell, Rochester, MN (USA) | ||
| Room C | Epidemiology and infections | |
| Chair: L. Arcaini, Pavia (Italy) | ||
| 17:15 | 093 | International dlbcl study finds biological heterogeneity between ethnically diverse countries but similar IPI-adjusted outcomes |
| R. Carr, London (UK) | ||
| 17:25 | 094 | Involvement of moraxella catarrhalis in the pathogenesis of hodgkin lymphoma (nodular lymphocyte predominant type, IGD-positive) |
| S. Hartmann, Frankfurt (Germany) | ||
| 17:35 | 095 | EPSTEIN-BARR virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival |
| C. Visco, Vicenza (Italy) | ||
| 17:45 | 096 | Exposure to hepatitis B virus (HBV), family history, and B-CELL non-hodgkin lymphoma (B-NHL): a case-control study among Jews and Arabs in Israel and the West bank |
| O. Paltiel, Jerusalem (Israel) | ||
| 17:55 | 097 | EBV positive dlbcl of the elderly is a heterogeneous disorder with outcome predicted by its immune microenvironment |
| C. Keane, Brisbane (Australia) | ||
| 18:05 | 098 | The role of HBV-infection in chronic lymphocytic leukemia |
| W. Xu, Nanjing (China) | ||
| Cinema Corso | Management of T-cell lymphoma | |
| Chair: F. d'Amore, Aahrus (Denmark) | ||
| 17:15 | 099 | CHOEP VS. CHOP gives better results in first-line therapy of T-cell lymphoma. A retrospective analysis from Czech lymphoma study group (CLSG) databse |
| A. Janikova, Brno (Czech Republic) | ||
| 17:25 | 100 | Long-term outcome of adults with ALCL after the first relapse/progression: A LYSA study |
| D. Sibon, Paris (France) | ||
| 17:35 | 101 | Prospective Phase II trial of lenalidomide in association with chop in elderly patients with angioimmunoblastic T-cell lymphoma (AITL): interim analysis of a LYSA study |
| V. Safar, Lyon (France) | ||
| 17:45 | 102 | Clinical outcomes and prognostic factors of up-front autologous stem cell transplantation in patients with extranodal NK/T-cell lymphoma |
| H. Yhim, Jeonju (Korea) | ||
| 17:55 | 103 | P-GEMOX regimen followed by extensive involved-field radiotherapy for newly diagnosed Stage I/II ENKTL |
| H. Hui-Qiang, Guangzhou (China) | ||
| 18:05 | 104 | HDAC inhibitor combinations exhibit synergy in pre- and clinical experiences in drug resistant T-cell lymphoma |
| O.A. O'Connor, New York, NY (USA) | ||
| Auditorium, University Campus | New drug combinations | |
| Chair: J.P. Leonard, New York, NY (USA) | ||
| 17:15 | 105 | Ublituximab (TG-1101), a novel glycoengineered anti-CD20 MAB, in combination with ibrutinib achieves 95% orr in patients with high-risk relapsed/?refractory CLL |
| J. Burke, Aurora, CO (USA) | ||
| 17:25 | 106 | The chemotherapy-free triplet of ublituximab, TGR-1202, and ibrutinib is safe and highly active in relapsed B-cell malignancies |
| L. Nastoupil, Houston, TX (USA) | ||
| 17:35 | 107 | A Phase 1 study of PI3Kδ inhibitor INCB040093 alone or in combination with selective JAK1 inhibitor INCB039110 in patients with relapsed/?refractory hodgkin lymphoma |
| A. Forero-Torres, Birmingham, AL (USA) | ||
| 17:45 | 108 | ABT-199 triggers apoptosis, and augments ibrutinib cytotoxicity in CXCR4 wild-type and whith mutated waldenstroem macroglobulinemia cells |
| J.J. Castillo, Boston, MA (USA) | ||
| 17:55 | 109 | Venetoclax (ABT-199/GDC-0199) in combination with bortezomib and dexamethasone in relapsed/?refractory multiple myeloma: Phase 1B results |
| A.A. Chanan-Khan, Jacksonville, FL (USA) | ||
| 18:05 | 110 | Cancer energy metabolism as a therapeutic target in refractory MYC+ diffuse large B-CELL lymphoma |
| C. Thieblemont, Paris (France) | ||
| Aula Magna, University Campus | Ongoing trials | |
| Chair: A. Davies, Southampton (UK) | ||
| 17:15 | OT01 | The IELSG-37 study: a randomized trial assessing the role of mediastinal radiotherapy after front-line rituximab and anthracycline containing regimens in patients with primary mediastinal large B-cell lymphoma (PMLBCL) |
| M. Martelli, Rome (Italy) | ||
| 17:25 | OT02 | Rochop study: a Phase III randomized study of chop compared to romidepsin-chop in untreated peripheral T-cell lymphoma |
| R. Delarue, Paris (France) | ||
| 17:35 | OT03 | CLL2-BIG, -BAG, -BCG AND -BIO: Four Phase-II trials evaluating a sequential tailored and targeted regimen aiming for total eradication of MRD in an all-comer CLL population |
| P. Cramer, Cologne (Germany) | ||
| 17:45 | OT04 | Phase 2 study of venetoclax (GDC-0199/ABT-199) plus bendamustine and rituximab (BR) vs. BR or venetoclax plus rituximab in relapsed/refractory FL |
| W. Hiddemann, Munich (Germany) | ||
| 17:55 | OT05 | DLC-002 (ROBUST): Phase III randomized, efficacy and safety study of lenalidomide plus R-chop vs R-chop in patients with untreated ABC-type diffuse large B-cell lymphoma |
| A. Chiappella, Turin (Italy) | ||
| 18:05 | OT06 | Randomized, multicenter, open-label, Phase 3 study of ibrutinib/?obinutuzumab vs. chlorambucil/obinutuzumab for treatment-naïve CLL/SLL (PCYC-1130; ILLUMINATE) |
| C. Moreno, Barcelona (Spain) |
| 08:30–18:30 Marquee | POSTER SESSION | |
| 08:00–08:45 5 parallel sessions | Article number | MEET THE PROFESSOR SESSIONS |
| Room A | I. | Hodgkin lymphoma: special challenges and solutions |
| J. M. Connors, Vancouver, British Columbia (Canada) | ||
| Room B | II. | Challenges in the management of PTLD |
| G. Gaidano, Novara (Italy) | ||
| Cinema Corso | IX. | Is it only about myc? how to approach the diagnosis of diffuse large B-cell lymphomas |
| L. Quintanilla-Martinez, Tuebingen (Germany) | ||
| Auditorium, University Campus | VIII. | Treatment of CLL, where are we heading? |
| S.M. O'Brien, Irvine, CA (USA) | ||
| Aula Magna, University Campus | VI. | FDG-pet as a biomarker in lymphoma: from qualitative to quantitative analysis |
| M. Meignan, Creteil (France) | ||
| 09:00–10:35 Room A and Marquee (overflow area) | Abstract number | SESSION 7 - LYMPHOMA BIOLOGY AND GENOMICS II |
| Co-Chairs: T.M. Mak, Toronto, ON (Canada) and L. Pasqualucci, New York, NY (USA) | ||
| 09:00 | 111 | Isocitrate dehydrogenase (IDH) mutations in angioimmunoblastic T-cell lymphoma (AITL) |
| T.M. Mak Toronto, ON (Canada) | ||
| 09:20 | 112 | Recurrent mutations in TCR (pathway)-related genes in TFH-derived peripheral T-cell lymphomas |
| D. Vallois, Lausanne (Switzerland) | ||
| 09:35 | 113 | HBZ, BCL-XL, AKT, and loss of INK4A/ARF synergistically transform primary murine T-cells and elicit ATL-like disease in mice |
| Y. Kasugai, Nagoya (Japan) | ||
| 09:50 | 114 | Whole genome sequencing in the framework of ICGC MMML-SEQ identifies PCBP1 as recurrently mutated in burkitt lymphoma |
| S.M. Aukema, Kiel (Germany) | ||
| 10:05 | 115 | Gene, mirna and pathway specific protein expression analysis in newly diagnosed MYC/BCL2 double expressing diffuse large B-cell lymphoma |
| E. Matsuki, New York, NY (USA) | ||
| 10:20 | 116 | Mechanisms of malignant transformation in TP53 wild-type burkitt lymphoma identified by integration of molecular and functional genomics data |
| J. Hüllein, Heidelberg (Germany) | ||
| 09:00–10:30 5 parallel sessions | ‘CASE DISCUSSION’ SESSIONS | |
| Room B | Aggressive lymphoma | |
| Chair: A. Lopez-Guillermo, Barcelona (Spain) | ||
| Discussants: U. Vitolo, Turin (Italy) and P. Hamlin, New York, NY (USA) | ||
| Room C | Lymphoma radiotherapy | |
| Chair: L. Specht, Copenhagen (Denmark) | ||
| Discussants: U. Ricardi, Turin (Italy) and J. Yahalom, New York, NY (USA) | ||
| Cinema Corso | Multiple myeloma | |
| Chair: S.V. Rajkumar, Rochester, MN (USA) | ||
| Discussants: M. Cavo, Bologna (Italy) and M. Coleman, New York, NY (USA) | ||
| Auditorium, University Campus | Mantle cell lymphoma | |
| Chair: S. Le Gouill, Nantes (France) | ||
| Discussants: M. Martelli, Rome (Italy) and P. Martin, New York, NY (USA) | ||
| Aula Magna, University Campus | Clinico-pathological discussion: border-line cases* | |
| Chair: M. Ghielmini, Bellinzona (Switzerland) | ||
| Presenters: S. Dirnhofer, Basel (Switzerland), E. Campo, Barcelona (Spain) and S.H. Swerdlow, Pittsburgh, PA (USA) | ||
| Discussants – M. Federico, Modena (Italy) and C.H. Moskowitz, New York, NY (USA) | ||
| *supported by an unrestricted grant by sigma-tau Research Switzerland SA | ||
| 10:30–11:00 Marquee | COFFEE BREAK | |
| 11:00–12:05 Room A, B and Marquee (overflow area) | SESSION 8 – HODGKIN'S LYMPHOMA | |
| Co-Chairs: R. Küppers, Essen (Germany) and J.A. Radford, Manchester (UK) | ||
| 11:00 | 117 | Introduction: Biology of Hodgkin lymphoma |
| R. Küppers, Essen (Germany) | ||
| 11:20 | 118 | Interim pet-adapted chemotherapy in advanced hodgkin lymphoma (HL). Results of the second interim analysis of the Italian GITIL/FIL DH0607 trial |
| A. Gallamini, Nice (France) | ||
| 11:35 | 119 | Interim pet response-adapted therapy in advanced stage hodgkin's lymphoma: Final results of the Phase II part of the fondazione italiana LINFOMI (FIL) HD0801 study |
| P.L. Zinzani, Bologna (Italy) | ||
| 11:50 | 120 | Analysis of primary-refractory hodgkin lymphoma pts in a randomized, placebo-controlled study of brentuximab vedotin consolidation after autologous stem cell transplant |
| C.H. Moskowitz, New York, NY (USA) | ||
| 12:05–13:00 Room E | 13-ICML PRESS CONFERENCE | |
| (open to all journalists) | ||
| 12:05–13:00 Marquee | LUNCH TIME AND POSTER VIEWING | |
| from 12:30 to 13:00 authors in front of their posters for discussion with attendees | ||
| 13:00–13:50 Room A, B and Marquee (overflow area) | JOHN ULTMANN MEMORIAL LECTURE* | |
| Chair: E.S. Jaffe, Bethesda, MD (USA) | ||
| *sponsored by European School of Oncology – ESO | ||
| 003 | Thirty years of progress in cutaneous lymphoma research | |
| R. Willemze, Leiden (The Nederlands) | ||
| 13:50–15:20 Room A, B and Marquee | SESSION 9 – INDOLENT LYMPHOMA | |
| Co-Chairs: B.S. Kahl, Madison, WI (USA) and A. Lopez-Guillermo, Barcelona (Spain) | ||
| 13:50 | 13-ICML WORKSHOP REPORT | |
| R.D. Gascoyne, Vancouver, BC (Canada) | ||
| 14:05 | 121 | Risk of transformation of follicular lymphoma and outcome in the immunochemotherapy era: ancillary study from the prima trial |
| C. Sarkozy, Pierre Bénite (France) | ||
| 14:20 | 122 | Complete response rate at 30 months (CR30) as a surrogate endpoint in first-line follicular lymphoma: a prospectively specified analysis using individual patient data |
| D.J. Sargent, Rochester, MN (USA) | ||
| 14:35 | 123 | Gadolin: primary results of a Phase III study of obinutuzumab plus bendamustine compared with bendamustine alone in patients with rituximab-refractory indolent lymphoma |
| B.D. Cheson, Washington, D.C. (USA) | ||
| 14:50 | 124 | A simple and effective malt lymphoma-specific prognostic index generated from the dataset of the IELSG-19 controlled clinical trial |
| C. Thieblemont, Paris (France) | ||
| 15:05 | 125 | BING-NEEL syndrome: a multi-institutional retrospective study |
| J.J. Castillo, Boston, MA (USA) | ||
| 15:20–15:40 | BREAK | |
| 15:40–16:15 Room A, B and Marquee (overflow area) | CONTROVERSY | |
| Early-stage HL: should interim pet-based therapy be considered routine clinical practice? | ||
| Chair: T.A. Lister, London (UK) | ||
| 006 | NO: M. Hutchings, Copenhagen (Denmark) vs | |
| 007 | YES: J.M. Connors, Vancouver, British Columbia (Canada) | |
| 16:15–17:45 Room A, B and Marquee (overflow area) | SESSION 10 – AGGRESSIVE LYMPHOMA | |
| Co-Chairs: U. Vitolo, Turin (Italy) and L.H. Sehn, Vancouver, BC (Canada) | ||
| 16:15 | 126 | Gray zone lymphoma (GZL): characteristics, outcomes and prognostication among a large multicenter cohort |
| A.M. Evens, Boston, MA (USA) | ||
| 16:30 | 127 | Ratios of T-cells to tumour associated macrophages and PD-1 axis molecules, add to the predictive power of conventional prognosticators in diffuse large B-cell lymphoma |
| M. Gandhi, Brisbane (Australia) | ||
| 16:45 | 128 | Continued risk of relapse independent of treatment modality in limited stage diffuse large B-CELL Lymphoma: final and long-term analysis of SWOG study S8736 |
| D.M. Stephens, Salt Lake City, UT (USA) | ||
| 17:00 | 129 | Treatment selection and survival outcomes in early-stage diffuse large B-cell lymphoma: Does modern chemotherapy replace the need for radiotherapy? |
| J.A. Vargo, Pittsburg, PA (USA) | ||
| 17:15 | 130 | Front line therapy with R-CODOX-M & R-IVAC in poor risk diffuse large B-cell lymphoma (IPI 3-5) yields a good outcome without transplantation: a Phase 2 UK NCRI/LLR trial |
| A.K. McMillan, Nottingham (UK) | ||
| 17:30 | 131 | Validation of the german high-grade non-hodgkin lymphoma study group (DSHNHL) prognostic model for CNS relapse in a large cohort of PET/CT staged patients |
| T.C. El-Galaly, Aalborg (Denmark) | ||
| 17:45 Marquee | FAREWELL APERO |
| 08:00–10:30 Room 159, University Campus | SPECIAL SESSION - CONTOURING IN MODERN LYMPHOMA RADIOTHERAPY PLANNING* | |
| A. Kiil Berthelsen, Copenhagen (Denmark), S. Qi, New York, NY (USA) and Beijing (China) and L. Specht, Copenhagen (Denmark) | ||
| Organized by International Lymphoma Radiation Oncology Group – ILROG and European Society for Radiotherapy and Oncology – ESTRO | ||
| * compulsory pre-registration | ||
| 08:30–10:00 2 parallel sessions | ||
| Room A | SESSION 11 – PRIMARY CNS LYMPHOMA | |
| Co-Chairs: G. Illerhaus, Stuttgart (Germany) and A.J. Ferreri, Milan (Italy) | ||
| 08:30 | 132 | High frequency of MYD88 mutations in vitreoretinal B-cell lymphoma: a valuable tool to improve diagnostic yield of vitreous body aspirates |
| I. Bonzheim, Tuebingen (Germany) | ||
| 08:45 | 133 | Genetic basis of primary central nervous system lymphoma |
| K. Yoshida, Kyoto (Japan) | ||
| 09:00 | 134 | Rituximab, methotrexate, procarbazine and lomustine for elderly primary CNS lymphoma patients – the primain-study by the german cooperative PCNSL group |
| B. Kasenda, Stuttgart (Germany) | ||
| 09:15 | 135 | Management and outcome of primary cns lymphoma at first relapse/progression: Analysis of 256 patients from the French LOC network |
| S. Langner-Lemercier, Rennes (France) | ||
| 09:30 | 136 | Phase I/II study of TEDDI-R with ibrutinib in untreated and relapsed/refractory primary CNS lymphoma |
| K. Dunleavy, Bethesda, MD (USA) | ||
| 09:45 | 137 | Lenalidomide is highly active in recurrent cns lymphomas: Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide as maintenance monotherapy |
| J.L. Rubenstein, San Francisco, CA (USA) | ||
| 08:40–10:00 Room B | SESSION 12 – IMMUNOTHERAPY | |
| Co-Chairs: R. Levy, Stanford, CA (USA) and F. Morschhauser, Lille (France) | ||
| 08:40 | 138 | Introduction: Immunotherapy of lymphoma 2015 |
| R. Levy, Stanford, CA (USA) | ||
| 09:00 | 139 | Phase II trial of chimeric antigen receptor modified T-cells directed against CD19 in relapsed/refractory diffuse large B-cell, follicular, and mantle cell lymphomas |
| S.J. Schuster, Philadelphia, PA (USA) | ||
| 09:15 | 140 | A Phase II a study of single-agent MOR208, an FC-optimized anti-CD19 antibody, in patients with relapsed or refractory B-cell non-hodgkin's lymphoma |
| P.L. Zinzani, Bologna (Italy) | ||
| 09:30 | 141 | Phase I, first-in-human trial of BI 836826 (an anti-CD37 antibody) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) |
| S. Stilgenbauer, Ulm (Germany) | ||
| 09:45 | 142 | Two doses of polatuzumab vedotin in patients with relapsed/?refractory (R/R) follicular lymphoma (FL): durable responses at lower dose |
| F. Morschhauser, Lille (France) | ||
| 10:00–11:20 Room A and B | SESSION 13 – TARGETTING INTRACELLULAR PATHWAYS | |
| Co-Chairs: M. Seto, Nagoya (Japan) and J.F. Seymour, Melbourne (Australia) | ||
| 10:00 | 143 | Introduction: Genetic and epigenetic heterogeneity of malignant lymphoma: challenging features |
| M. Seto, Nagoya (Japan) | ||
| 10:20 | 144 | Epigenetic control of cellular senescence in tumor development and lymphoma treatment |
| C.A. Schmitt, Berlin (Germany) | ||
| 10:35 | 145 | Phase 1 study of E7438 (EPZ-6438), an enhancer of ZESTE-HOMOLOG 2 (EZH2) inhibitor: dose determination and preliminary activity in non-hodgkin lymphoma |
| V. Ribrag, Villejuif (France) | ||
| 10:50 | 146 | Selinexor shows activity in double-hit diffuse large B-cell lymphoma in pre-clinical models and in-patients with relapsed/?refractory double-hit DLBCL |
| R. Garzon, Columbus, OH (USA) | ||
| 11:05 | 147 | Phase 1 preliminary safety, efficacy and biomarker data from venetoclax (ABT-199/GDC-0199) + bendamustine and rituximab in R/R non-hodgkin's lymphoma |
| S. de Vos, Los Angeles, CA (USA) | ||
| 11:20–11:45 Room A and B | 13-ICML HIGHLIGHTS | |
| TAKE HOME MESSAGES | ||
| J.W. Friedberg, Rochester, NY (USA) | ||
| 11:45–11:55 | CLOSURE AND FAREWELL | |
| F. Cavalli, Bellinzona (Switzerland) | ||
| 13:30–18:00 Room B | WORKSHOP: ‘CANINE LYMPHOMAS: STATE OF THE ART AND COMPARATIVE ASPECTS WITH HUMAN DISEASE’* | |
| Co-Chairs: S. Comazzi, Milan (Italy), F. Guscetti, Zurich (Switzerland) and L. Marconato, Bologna (Italy) | ||
| Organized by the European Canine Lymphoma Group | ||
| *open to all 13-ICML attendees |
This icon denotes presentations that will be available online, only for 13-ICML attendees, between July 15 and September 15, 2015.
Please note that this version of the program (last updated on May 08, data of printing) may differ from the final program. Changes communicated to 13-ICML Secretariat after this date could not be included.
Note: The articles published in the 13-ICML Educational Book represent the presentations made at the “Meet the Professor” sessions and “Educational Symposia” during the 13th International Conference on Malignant Lymphoma (13-ICML) held in Lugano, Switzerland on June 17–20, 2015.
All manuscripts submitted have been subjected to peer review, and authors have been requested to disclose any relationships with the companies whose products or services are discussed in their manuscripts.
Prof Michele Ghielmini, as guest editor, has reported no financial relationships with companies whose products are mentioned in this supplement.
The 13-ICML Local Organizing Committee wishes to thank the following colleagues for their professional help:
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