Acknowledgements


13-ICML President

  • F. Cavalli, Bellinzona (Switzerland)

13-ICML Local Organizing Committee

  • (based in Bellinzona, Switzerland)
  • F. Bertoni
  • M. Ghielmini – Chairman
  • A. Moccia
  • F. Peccatori – European School of Oncology representative
  • A. Stathis
  • G. Stüssi
  • E. Zucca

Advisory Board

  • J.O. Armitage, Omaha, NE (USA) – President
  • E. Campo, Barcelona (Spain)
  • B.D. Cheson, Washington, DC (USA)
  • J.M. Connors, Vancouver, British Columbia (Canada)
  • F.E. Cotter, London (UK)
  • R. Dalla-Favera, New York, NY (USA)
  • S. Dirnhofer, Basel (Switzerland)
  • M. Dreyling, Munich (Germany)
  • A. Engert, Cologne (Germany)
  • M.F. Fey, Bern (Switzerland)
  • J.W. Friedberg, Rochester, NY (USA)
  • G. Gaidano, Novara (Italy)
  • R.D. Gascoyne, Vancouver, British Columbia (Canada)
  • P. Gaulard, Créteil (France)
  • M.K. Gospodarowicz, Toronto, Ontario (Canada)
  • M. Hallek, Cologne (Germany)
  • E.S. Jaffe, Bethesda, MD (USA)
  • P.W.M. Johnson, Southampton (UK)
  • R. Küppers, Essen (Germany)
  • J.P. Leonard, New York, NY (USA)
  • T. A. Lister, London (UK)
  • A. Lopez-Guillermo, Barcelona (Spain)
  • M.A. Piris, Santander (Spain)
  • S.V. Rajkumar, Rochester, MN (USA)
  • M. Seto, Nagoya (Japan)
  • J.F. Seymour, Melbourne (Australia)
  • M.A. Shipp, Boston, MA (USA)
  • L. Specht, Copenhagen (Denmark)
  • L.M. Staudt, Bethesda, MD (USA)
  • C. Thieblemont, Paris (France)
  • K. Tobinai, Tokyo (Japan)
  • U. Vitolo, Turin (Italy)
  • A. Younes, New York, NY (USA)
  • W. Wössmann, Giessen (Germany)

Conference Secretariat and Local Organization:

  • (based in Bellinzona, Switzerland)
  • C. Brentan, O. Lugli, C. Saporiti.

The conference organizers wish to thank the following sponsors for their unrestricted financial support:

  • Abbvie
  • Acerta Pharma
  • Amgen (Europe) GmbH
  • Bayer HealthCare Pharmaceuticals, Inc.
  • Bristol-Myers Squibb
  • Celgene Corporation
  • CTI Life Sciences Ltd.
  • F. Hoffmann-La Roche Ltd.
  • Gilead Sciences, Inc.
  • Gilead Sciences Europe Ltd.
  • Infinity Pharmaceuticals, Inc.
  • Institut Biochimique SA – IBSA
  • Janssen Pharmaceutical Companies of Johnson & Johnson
  • Medicom Worldwide, Inc.
  • Mentrik Biotech, LLC
  • Mundipharma Oncology
  • Novartis Oncology
  • Pfizer Oncology
  • Seattle Genetics, Inc.
  • Servier
  • sigma-tau Research Switzerland SA
  • Spectrum Pharmaceuticals, Inc.
  • Takeda Oncology
  • Vifor SA

The conference organizers wish to thank the following contributors for their support:

  • American Association for Cancer Research – AACR
  • Arcobaleno – Comunità Tariffale Ticino e Moesano
  • City of Lugano
  • European School of Oncology – ESO
  • European Society for Medical Oncology – ESMO
  • European Society for Radiotherapy and Oncology - ESTRO
  • Hotel Splendide Royal
  • Institut Carnot – CALYM
  • International Extranodal Lymphoma Study Group – IELSG
  • International Lymphoma Radiation Oncology Group – ILROG
  • Kompetenznetz Maligne Lymphome e.V. – KML
  • Leukämiehilfe Rhein-Main g.e.V. – LHRM
  • Lugano University Campus
  • Lymphoma Coalition
  • Lymphoma HUB
  • Omega SA
  • Repubblica e Cantone Ticino/Fondo Swisslos
  • San Salvatore Foundation
  • Schweizerische Patientenorganisation für Lymphombetroffene und Angehörige – ho / noho
  • Swiss Cancer League
  • Swiss Cancer Research Foundation
  • Swiss International Air Lines
  • The Leukemia Lymphoma Society
  • The MDS Alliance
  • Ticino Tourism

SAVE THE DATE: 14-ICML – 14th International Conference on Malignant Lymphoma

Lugano, Switzerland

June 14-17, 2017

Satellite Symposia Schedule

Tuesday, June 16, 2015

12:00 to 14:00 (room B I)AMGEN (EUROPE) GmbH
NOVEL APPROACHES TO LYMPHOMA AND LEUKEMIA: ENGAGING THE T-CELL WITH BISPECIFIC ANTIBODY CONSTRUCTS
Chair: M. Ghielmini, Bellinzona (Switzerland)
15:30 to 17:30 (room B I)NOVARTIS ONCOLOGY
MORE EVIDENCE, MORE OPTIONS: FIRST-LINE TREATMENT OF CLL
Chair: K. Stamatopoulos, Thessaloniki (Greece)
15:30 to 17:30 (room B II)CTI LIFE SCIENCES LIMITED and SERVIER
CHANGING EXPECTATIONS IN THE TREATMENT OF RELAPSED AND REFRACTORY AGGRESSIVE NHL
Chair: M. Ghielmini, Bellinzona (Switzerland)
19:00 to 21:00 (room A)BRISTOL-MYERS SQUIBB
IMMUNO-ONCOLOGY: A NEW ERA IN HEMATOLOGY TREATMENT? EMERGING RESEARCH IN LYMPHOMA AND MYELOMA
Chair: A. Engert, Cologne (Germany)
19:00 to 21:00 (room B I)BAYER HEALTHCARE PHARMACEUTICALS, Inc.
THE EVOLVING THERAPEUTIC POTENTIAL OF PI3K INHIBITORS IN RELAPSED OR REFRACTORY NON-HODGKIN'S LYMPHOMA
Chair: M. Ghielmini, Bellinzona (Switzerland)
19:00 to 21:00 (room B II)TAKEDA ONCOLOGY, SEATTLE GENETICS, Inc., THE LEUKEMIA LYMPHOMA SOCIETY and MEDICOM WORLDWIDE, Inc.
CONTEMPORARY THERAPY FOR HODGKIN LYMPHOMA: WHERE ARE WE NOW?
Chair: F. Cavalli, Bellinzona (Switzerland)

Wednesday, June 17, 2015

19:00 to 21:00 (room A)JANSSEN PHARMACEUTICAL COMPANIES OF JOHNSON & JOHNSON
CHALLENGING THE PARADIGMS IN B-CELL MALIGNANCIES
Co-chairs: M. Dreyling, Munich (Germany) and S. Rule, Plymouth (UK)
19:00 to 21:00 (room B)GILEAD SCIENCES EUROPE, Ltd.
NEW OPTIONS AND EVOLVING STRATEGIES IN THE MANAGEMENT OF HEMATOLOGICAL MALIGNANCIES
Co-Chairs: M. Hallek, Cologne (Germany) and G. Salles, Lyon (France)

Thursday, June 18, 2015

19:00 to 21:00 (room A)CELGENE CORPORATION
IMMUNE-BASED STRATEGIES TOWARDS ADVANCING THE TREATMENT OF B-CELL MALIGNANCIES
Chair: F. Cavalli, Bellinzona (Switzerland)
19:00 to 21:00 (room B)
MUNDIPHARMA ONCOLOGY
CLL AND FOLLICULAR NHL: CRITICAL REVIEW OF THE CURRENT GUIDELINES AND FUTURE PERSPECTIVES
Co-chairs: J.G. Gribben, London (UK) and M. Ghielmini, Bellinzona (Switzerland)

Friday, June 19, 2015

18:45 to 19:45 (room A)
ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND – IOSI
Supported by an unrestricted educational grant by GILEAD SCIENCES EUROPE, Ltd.
THE BIG DEBATE: SHOULD WE ALWAYS AIM AT MINIMAL RESIDUAL DISEASE ERADICATION?
Chair: M. Ghielmini, Bellinzona (Switzerland)

Conference Schedule

Tuesday, June 16, 2015
09:30–17:30 Auditorium, University CampusClosed workshop: ‘follicular lymphoma: recent insights and future directions (moving towards biology-driven treatments?)’*
Co-Chairs: R.D. Gascoyne, Vancouver, BC (Canada) and E. Zucca, Bellinzona (Switzerland)
Supported by American Association for Cancer Research – AACR and European School of Oncology – ESO
*by invitation only
15:00–18:00workshop on radiotherapy for lymphoma: ‘controversies in the use of radiation therapy for advanced stage lymphoma’**
Cinema CorsoCo-Chairs: D. Hodgson, Toronto, ON (Canada) and T. Illidge, Manchester (UK)
Organized by International Lymphoma Radiation Oncology Group – ILROG
**open to all 13-ICML attendees
Wednesday, June 17, 2015
08:30–12:00 POSTER SESSION SET UP (Marquee Parco Ciani)
08:30–09:15 5 parallel sessionsArticle number‘MEET THE PROFESSOR’ SESSIONS image
Room AIV.Masses in the mediastinum: primary mediastinal lymphoma and intermediate types
P.M.W. Johnson, Southampton (UK)
repeated on Thursday, June 18, in Auditorium, University Campus
Room BVII.Are lymphomas driven by epigenetic lesions? A.M. Melnick, New York, NY (USA)
repeated at 09:30 in Cinema Corso
Cinema CorsoX.Challenges and future directions in peripheral t-cell lymphoma
K.J. Savage, Vancouver, British Columbia (Canada)
repeated at 09:30 in Room B
Auditorium, University CampusIII.Current concepts in primary central nervous lymphoma
G. Illerhaus, Stuttgart (Germany)
repeated on Thursday, June 18, in Cinema Corso
Aula Magna, University CampusIX.Is it only about myc? how to approach the diagnosis of diffuse large b-cell lymphomas
L. Quintanilla-Martinez, Tuebingen (Germany)
repeated on Friday, June 19, in Cinema Corso
09:30–10:15 5 parallel sessions  
Room AVIII.Treatment of cll, where are we heading?
S.M. O'Brien, Irvine, CA (USA)
repeated on Friday, June 19, in Auditorium, University Campus
Room BX.Challenges and future directions in peripheral t-cell lymphoma
K.J. Savage, Vancouver, BC (Canada)
Cinema CorsoVII.Are lymphomas driven by epigenetic lesions?
A.M. Melnick, New York, NY (USA)
Auditorium, University CampusXII.Therapeutic exploitation of autologous t-cell activation in b-cell lymphoma
A. Younes, New York, NY (USA)
repeated on Thursday, June 18, in Room A
Aula Magna, University CampusVI.FDG-pet as a biomarker in lymphoma: from qualitative to quantitative analysis
M. Meignan, Creteil (France)
repeated on Friday, June 19, in Aula Magna, University Campus
10:15–10:35 COFFEE BREAK (Marquee Parco Ciani)
10:35–12:00 2 parallel sessions EDUCATIONAL SYMPOSIA image
Room A – Marquee (overflow area) HISTOLOGICAL TRANSFORMATION IN LYMPHOMA: CLINICAL, PATHOLOGICAL AND MOLECULAR FEATURES
Chair: J.G. Gribben, London (UK)
  LECTURES:
 XIII.Molecular pathogenesis of transformed lymphomas
D. Rossi, Novara (Italy)
 XIV.The pathology of transformation of lymphoma
R.D. Gascoyne, Vancouver, BC (Canada)
 XV.Clinical aspects of transformed lymphoma
J.G. Gribben, London (UK)
Room B Hodgkin lymphoma – challenges and opportunities
Chair: R.H. Advani, Stanford, CA (USA)
  LECTURES:
 XVI.Early stage hodgkin lymphoma
J.A. Radford, Manchester (UK)
 XVII.Treatment of advanced-stage hodgkin lymphoma
A. Engert, Cologne (Germany)
 XVIII.Management of nodular lymphocyte predominant hodgkin lymphoma
R.H. Advani, Stanford, CA (USA)
12:00–18:30 MarqueeAbstract numberPOSTER SESSION
(printing of the posters sponsored by Takeda Oncology)
 148–170Pathology and biology
 171–181Hodgkin lymphoma
 182–186CLL
 187–201Indolent lymphoma
 202–209Mantle cell lymphoma
 210–224Aggressive b-cell lymphoma
 225–230Extranodal lymphoma
 231–250T-Cell lymphoma
 251–259Imaging
 260–279Pre-clinical studies
 280–287Early clinical trials
 OT07–OT15Ongoing trials
12:00–13:00 Marquee LUNCH TIME AND POSTER VIEWING
13:00–14:00 Room A, B and Marquee (overflow area) OPENING OF THE CONFERENCE image
Welcome and introductory remarks
F. Cavalli, Bellinzona (Switzerland)
  Henry kaplan memorial lecture and san salvatore foundation award image
  Introduction to San Salvatore Foundation: L. Butti, Lugano (Switzerland)
Laudatio: R. Stahel, Zurich (Switzerland)
 001Therapy of lymphoma inspired by functional and structural genomics
L.M. Staudt, Bethesda, MD (USA)
14:00–15:15 Room A, B and Marquee (overflow area) PLENARY SESSION
Co-Chairs: G.P. Canellos, Boston, MA (USA) and J.W. Friedberg, Rochester, NY (USA)
14:00008Response-adapted therapy based on interim fdg-pet scans in advanced hodgkin lymphoma: first analysis of the safety of de-escalation and efficacy of escalation in the international rathl study (CRUK/07/033)
  P.M.W. Johnson, Southampton (UK)
14:15 Discussant: A. Engert, Cologne (Germany)
14:25009Addition of thiotepa and rituximab to antimetabolites significantly improves outcome in primary cns lymphoma: first randomization of the IELSG32 trial
  A.J. Ferreri, Milan (Italy)
14:40 Discussant: T.T. Batchelor, Boston, MA (USA)
14:50010Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical hodgkin lymphoma: updated results of a Phase 1 study (CA209-039)
  J. Timmerman, Los Angeles, CA (USA)
15:05 Discussant: A. Younes, New York, NY (USA)
15:15–15:40 Marquee COFFEE BREAK
15:40–16:40 Room A, B and Marquee (overflow area) AACR-ICML JOINT SESSION: SPECIAL LECTURES
Co-Chairs: F. Cavalli, Bellinzona (Switzerland) and M. Foti, Philadelphia, PA (USA)
15:40004Update on the revision of the who lymphoma classification
S.H. Swerdlow, Pittsburgh, PA (USA)
16:10005What's new in multiple myeloma?
S.V. Rajkumar, Rochester, MN (USA)
16:40–17:15 BREAK
17:15–18:15 6 parallel sessions ‘FOCUS ON…’ SESSIONS
Room A IMIDs in lymphoma
Chair: N. Fowler, Houston, TX (USA)
17:15011Independent review of ct responses in the trial SAKK35/10 comparing rituximab with or without lenalidomide in untreated FL patients in need of therapy
  E. Zucca, Bellinzona (Switzerland)
17:25012Rituximab+Lenalidomide in malt lymphoma: final results
  M. Raderer, Vienna (Austria)
17:35013Lenalidomide added to bendamustine-rituximab for untreated chronic lymphocytic leukemia (CLL): a Phase 1 study
  J.S. Abramson, Boston, MA (USA)
17:45014Rituximab, lenalidomide, bendamustine second line therapy in mantle cell lymphoma: A Phase II study of the fondazione italiana linfomi (FIL)
  F. Zaja, Udine (Italy)
17:55015Rituximab, bendamustine and lenalidomide in patients with relapsed/refractory aggressive b-cell lymphoma not eligible for salvage chemotherapy. Phase II trial – SAKK 38/08
  F. Hitz, St. Gallen (Switzerland)
18:05016A Phase I/II trial of the combination of romidepsin and lenalidomide in patients with relapsed/refractory lymphoma and myeloma
  N. Mehta-Shah, New York, NY (USA)
Room B Genomic alterations
Chair: G. Gaidano, Novara (Italy)
17:15017Sequence-based panomics analyses by the ICGC MMML-SEQ deciphers multi-layer pathway deregulation in germinal center derived B-cell lymphomas
  R. Siebert, Kiel (Germany)
17:25018Structural variants in germinal-center derived B-cell lymphomas: analyses in the framework of the ICGC MMML-SEQ porject
  C. Lopez, Kiel (Germany)
17:35019Comprehensive genomic profiling of diffuse large B-cell lymphoma in the clinical setting
  J. He, Cambridge, MA (USA)
17:45020Targeted genomic sequencing prospectively identifies clinically relevant genetic alterations across lymphoma subtypes
  C.L. Batlevi, New York, NY (USA)
17:55021Posttransplant diffuse large B-cell lymphoma and burkitt lymphoma: new genetic findings
  I. Wlodarska, Leuven (Belgium)
18:05022Microrna-150 influences microenvironmental interactions and prognosis of follicular lymphoma
  M. Mraz, Brno (Czech Republic)
Room C Clinicopathological correlations
Chair: M.A. Piris, Santander (Spain)
17:15023Frequencies of lymphoma entities and impact of diagnostic review: a french experience on 35.753 lymphomas over 2010–2013
  C. Laurent, Toulouse (France)
17:25024Rituximab treatment in follicular lymphoma circumvents the prognostic value of intra-tumoral t-cells: automated image analysis of the lysa prima trial
  L. Xerri, Marseille (France)
17:35025Cell of origin (COO) assignment in transformed follicular lymphoma
  R. Kridel, Vancouver, British Columbia (Canada)
17:45026NOTCH1/2 mutations are recurrently found in cyclin D1-negative SOX11-positive mantle cell lymphoma
  I. Salaverria, Barcelona (Spain)
17:55027Clinicopathological study of HHV8-negative body cavity-based lymphoma (BCBL)
  D. Kaji, Tokyo (Japan)
18:05028Grey zone lymphoma between classical hodgkin lymphoma and diffuse large B-cell lymphoma: a lysa retrospective analysis
  C. Sarkozy, Pierre Bénite (France)
Cinema Corso Transplantation
Chair: S. Montoto, London (UK)
17:15029Beam plus rituximab or radioimmunotherapy versus beam for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma: a retrospective study of the LWP-EBMT
  L. Bento, Paris (France)
17:25030Outcome of reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after a previous autologous stem cell transplant
  S. Robinson, Bristol (UK)
17:35031A UK lymphoma clinical study group Phase II evaluation of high-dose chemotherapy and autologous stem cell transplantation in intestinal and other aggressive t-cell lymphomas
  M.M. Lannon, Newcastle upon Tyne (UK)
17:45032Allogeneic transplantation for T-cell lymphomas: no difference in outcome between patients allografted up-front and in first chemosensitive relapse
  A. Dodero, Milan (Italy)
17:55033Allogeneic or autologous transplantation as first-line therapy for younger patients with peripheral T-cell lymphoma – results of the interim analysis of the AATT trial
  N. Schmitz, Hamburg (Germany)
18:05034Post transplant cyclophosphamide reduces non relapse mortality of haplo-identical transplants yielding similar outcomes as with matched sibling donors
  S. Dietrich, Heidelberg (Germany)
Auditorium, University Campus Novel agents
Chair: G. Salles, Pierre Bénite (France)
17:15035Lipid addiction of DLBCL: involvement of PI3K signaling and potential therapeutic strategies via fatty acid synthase small molecule inhibitors
  A. Evens, Boston, MA (USA)
17:25036EZH2 and MYD88 mutations appear associated with antitumor activity of three new bet bromodomain inhibitors (BAY-5627, BAY-7575 and BAY-8097) in preclinical lymphoma models
  E. Bernasconi, Bellinzona (Switzerland)
17:35037Venetoclax (ABT-199/GDC-0199) monotherapy for relapsed/?refractory (r/r) multiple myeloma (MM): Phase 1 results
  S. Heitner Enschede, Chicago, IL (USA)
17:45038TGR-1202, a novel once daily PI3Kδ inhibitor, demonstrates clinical activity with a favorable safety profile, lacking hepatotoxicity in patients with cll and B-cell lymphoma
  H.A. Burris III, Nashville, TN (USA)
17:55039Ongoing, first-in-human, Phase 1 dose-escalation study of investigational SYK inhibitor TAK-659 in patients with advanced solid tumors or lymphoma
  A.M. Petrich, Chicago, IL (USA)
18:05040ARGX-110, a novel monoclonal antibody targeting CD70, is associated with biological activity in patients with relapsed/?refractory T-cell lymphomas
  M. Maerevoet, Villejuif (France)
Aula Magna, University Campus Short- and long-term toxicity of lymphoma therapies
  Chair: M.F. Fey, Bern (Switzerland)
17:15041Pulmonary function and grade 3/4 clinical events in pet negative patients taking part in the international rathl trial (CRUK/07/033): a comparison of 12 vs 4 doses of bleomycin
  C. Hague, Manchester (UK)
17:25042SYK & PI3K δ pathway inhibition resulted in increased rates of pneumonitis: implications for developing future small molecule combinations
  P.M. Barr, Rochester, NY (USA)
17:35043Cardiovascular disease after therapy for hodgkin lymphoma: a detailed analysis of 9 collaborative eortc-LYSA trials
  M. Maraldo, Copenhagen (Denmark)
17:45044A radiation dose-response relationship for risk of coronary heart disease in survivors of hodgkin lymphoma: a case-control study
  B.M. Aleman, Amsterdam (The Netherlands)
17:55045Anticoagulant/antiplatelet therapy concomitant with idelalisib in chronic lymphocytic leukemia and indolent NHL: use and outcomes
  P. Ghia, Milan (Italy)
18:05046Patterns of cognitive difficulties after treatment for lymphoma
  O.C. Lindner, Manchester (UK)
Thursday, June 18, 2015
08:30–18:30 Marquee POSTER SESSION
08:00–08:45 5 parallel sessionsArticle number‘MEET THE PROFESSOR’ SESSIONS image
Room AXII.Therapeutic exploitation of autologous T-cell activation in B-cell lymphoma
  A. Younes, New York, NY (USA)
Room BXI.Management of pediatric and adult non hodgkin lymphoma: what lessons can each teach the other?
  B. Burkhardt, Muenster (Germany) and J.F. Seymour, Melbourne (Australia)
Cinema CorsoIII.Current concepts in primary central nervous lymphoma
  G. Illerhaus, Stuttgart (Germany)
Auditorium, University CampusIV.Masses in the mediastinum: primary mediastinal lymphoma and intermediate types
  P.M.W. Johnson, Southampton (UK)
Aula Magna, University CampusV.Smoldering multiple myeloma
  M.V. Mateos, Salamanca (Spain)
09:00–10:35 Room A and Marquee (overflow area)Abstract numberSESSION 1 – LYMPHOMA BIOLOGY AND GENOMICS I
  Co-Chairs: R. Dalla-Favera, New York, NY (USA) and R.D. Gascoyne, Vancouver, British Columbia (Canada)
09:00047Introduction: Germinal centers and lymphomagenesis
  R. Dalla-Favera, New York, NY (USA)
09:20048Whole exome sequencing of refractory aggressive B-cell lymphomas identified recurrent mutations of the exportin 1 gene (XPO1) in primary mediastinal B-cell lymphoma subtype. a LYSA study
  F. Jardin, Rouen (France)
09:35049Recurrent somatic mutations in diffuse large b-cell lymphoma assessed by high-throughput targeted sequencing highlight molecular subtypes' genetic divergence: a LYSA study
  S. Dubois, Rouen (France)
09:50050A modified autoantigen is the first molecularly defined risk factor and a dominant antigenic target / stimulus of the b-cell receptor from ABC-type DLBCL
  M. Pfreundschuh, Homburg (Germany)
10:05051The role of tonic bcr signaling in a mouse model of MYC-driven lymphoma
  S. Casola, Milan (Italy)
10:20052Recurrent mtorc1-activating RRAGC mutations are a feature of follicular lymphoma
  J. Okosun, London (UK)
09:00–10:30 5 parallel sessions ‘CASE DISCUSSION’ SESSIONS
  Italian Lymphoma Foundation – FIL vs Cornell University and Memorial Sloan-Kettering Cancer Center in New York, NY (USA)
Room B Indolent lymphoma
  Chair: A. Davies, Southampton (UK)
  Discussants: L. Arcaini, Pavia (Italy) and J.P. Leonard, New York, NY (USA)
Room C Pediatric and adolescent lymphoma
  Chair: W. Wössmann, Giessen (Germany)
  Discussants: M. Pillon, Padua (Italy) and C.E. Allen, Houston, TX (USA)
Cinema Corso CLL
  Chair: J.G. Gribben, London (UK)
  Discussants: R. Foà, Rome (Italy) and A.D. Zelenetz, New York, NY (USA)
Auditorium, University Campus T-cell lymphoma
  Chair: F. d'Amore, Aarhus (Denmark)
  Discussants: P. Corradini, Milan (Italy) and S. Horwitz, New York, NY (USA)
Aula Magna, University Campus Hodgkin lymphoma
  Chair: J.A. Radford, Manchester (UK)
  Discussants: P.L. Zinzani, Bologna (Italy) and A. Younes, New York, NY (USA)
10:35–11:00 Marquee COFFEE BREAK
11:00–12:00 Room A, B and Marquee (overflow area) SESSION 2 – ADVANCES IN CLL
  Co-Chairs: M. Hallek, Cologne (Germany) and A.D. Zelenetz, New York, NY (USA)
11:00053In-vivo studies of kinetics in chronic lymphocytic leukaemia provide definitive evidence of LYMPH-node re-entry and suggest that there is a non-proliferative sub-clone
  K. Cuthill, London (UK)
11:15054The international prognostic index for patients with chronic lymphocytic leukemia (CLL-IPI) – an international meta-analysis
  J. Bahlo, Cologne (Germany)
11:30055Efficacy of ibrutinib vs ofatumumab by cytogenetic and clinical subgroups in a Phase 3 trial in patients with previously treated CLL/SLL
  P. Thornton, Dublin (Ireland)
11:45056BFR (bendamustine, fludarabine, rituximab) allogeneic conditioning improves survival in CLL
  I.F. Khouri, Houston, TX (USA)
12:00–13:00 Marquee LUNCH TIME AND POSTER VIEWING
  from 12:30 to 13:00 authors in front of their posters for discussion with attendees
13:00–13:45 Room A, B and Marquee (overflow area) HENRY RAPPAPORT MEMORIAL LECTURE image
  Chair: P. Gaulard, Créteil (France)
 002MANTLE CELL LYMPHOMA, AN UNFOLDING STORY FROM THE MICROSCOPE TO THE GENOME
  E. Campo, Barcelona (Spain)
13:00–17:00 Cinema Corso WORKSHOP FOR RADIATION ONCOLOGISTS
  Co-Chairs: M.K. Gospodarowicz, Toronto (Canada) and L. Specht, Copenhagen (Denmark)
  Organized by International Lymphoma Radiation Oncology Group - ILROG
  Part 1: Technical challenges in radiation therapy of lymphomas
  B. Dabaja, Houston, TX (USA)
  Part 2: Panel discussion: COMPETENCIES FOR RADIATION ONCOLOGISTS WITH SPECIAL EXPERTISE IN LYMPHOMAS
13:45 – 15:15 Room A, B and Marquee (overflow area) SESSION 3 – MANTLE CELL LYMPHOMA
Co-Chairs: M. Dreyling, Munich (Germany) and P. Martin, New York, NY (USA)
13:45057PI3K INACTIVATION AND REDOX STRESS MEDIATES THERAPEUTIC TARGETING OF CDK4 IN MCL
  S. Chen-Kiang, New York NY (USA)
14:00058PROGNOSTIC VALUE OF PROLIFERATION, CYTOLOGY, AND GROWTH PATTERN IN MANTLE CELL LYMPHOMA: RESULTS FROM RANDOMIZED TRIALS OF THE EUROPEAN MCL NETWORK
  E. Hoster, Munich (Germany)
14:15059RITUXIMAB, BENDAMUSTINE AND CYTARABINE (RBAC500) AS INDUCTION THERAPY IN ELDERLY PATIENTS WITH MANTLE CELL LYMPHOMA: A PHASE 2 STUDY FROM THE FONDAZIONE ITALIANA LINFOMI
  C. Visco, Vicenza (Italy)
14:30060LENALIDOMIDE-RITUXIMAB-BENDAMUSTINE IN FIRST LINE FOR PATIENTS > 65 WITH MANTLE CELL LYMPHOMA: FINAL RESULTS OF THE NORDIC LYMPHOMA GROUP MCL4 (LENA-BERIT) PHASE I/II TRIAL
  A. Albertsson-Lindblad, Lund (Sweden)
14:45061RITUXIMAB MAINTENANCE VERSUS WW AFTER R-DHAP PLUS ASCT IN UNTREATED PATIENTS WITH MCL: INTERIM ANALYSIS OF THE LYMA TRIAL, A LYSA STUDY
  S. Le Gouill, Nantes (France)
15:00062RESULTS OF A RANDOMIZED PHASE II TRIAL OF R-HCVAD VS. R-BENDAMUSTINE FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTS FOR PATIENTS WITH MANTLE CELL LYMPHOMA: US INTERGROUP S1106
  R. Chen, Duarte, CA (USA)
14:45–16:55 SESSION 4 - PEDIATRIC LYMPHOMA
Room C Chair: W. Wössmann, Giessen (Germany)
14:45063Nodular lymphocyte predominant hodgkin lymphoma in children and adolescents: therapeutic approaches and grey zone to mature B-NHL
  C. Mauz-Körholz, Halle (Germany)
15:05064New targets for the treatment of mature B-NHL
  F. Jardin, Rouen (France)
15:25–15:40 COFFEE BREAKInside Room C for session 4 attendees
15:40065Results of the randomized trial EURO-LB02 on lymphoblastic lymphoma in children and adolescents – a report of the European intergroup for childhood non-hodgkin lymphoma
  B. Burkhardt, Muenster (Germany)
15:55066Relapses in children/adolescents with mature B-cell lymphoma/leukemia treated in the rituximab era – a study of the Société Française des Cancers de L'enfant
  V. Minard-Colin, Villejuif (France)
16:10067Treatment and characterization of patients with Burkitt Lymphoma (BL): Results from a single institution in Northern Uganda
  V. Calbi, Gulu (Uganda)
16:25068Risk-adapted approach for patients with relapsed or refractory ALCL – final report of the prospective ALCL-relapse trial of the EICNHL
  S. Ruf, Giessen (Germany)
16:40069Lymphoma associated with a constitutional mismatch repair deficiency syndrome: clinical description in a french cohort
  N. Lavoine, Villejuif (France)
15:15–15:35 Marquee COFFEE BREAK
15:35–17:05Room A and Marquee (overflow area) SESSION 5 – T-CELL LYMPHOMA
  Co-Chairs: K. Tobinai, Tokyo (Japan) and J.M. Vose, Omaha, NE (USA)
15:35070T-cell project: an international, prospective, observational study of patients with aggressive peripheral NK/T-cell lymphoma. lesson from the first 1308 patients
  M. Federico, Modena (Italy)
15:50071The genetic landscape of hepatosplenic T-cell lymphoma reveals novel strategies for treatment and risk-stratification
  P. Gaulard, Créteil (France)
16:05072A PTCL, NOS subset with molecular and clinical features similar to AITL
  M. Dobay, Lausanne (Switzerland)
16:20073Radiation therapy for primary cutaneous anaplastic large cell lymphoma (pcALCL): an international lymphoma radiation oncology group (ILROG) multi-institutional experience
  R.T. Hoppe, Stanford, CA (USA)
16:35074Ten years median follow-up of the Nordic NLG-T-01 trial on choep and upfront autologous transplantation in peripheral T-cell lymphomas
  F. d'Amore, Aarhus (Denmark)
16:500755-year follow-up of the smile Phase II study for newly-diagnosed Stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type
  R. Suzuki, Izumo (Japan)
15:35–16:55 SESSION 6 – INTERFERING WITH BCR-NFKB PATHWAYS
Room B Co-Chairs: M.A. Shipp, Boston, MA (USA) and F.E. Cotter, London (UK)
15:35076Introduction: BCR SIGNALING AND SURVIVAL PATHWAYS IN LYMPHOMA
  M.A Shipp, Boston, MA (USA)
15:55077Ibrutinib is highly active and produces durable responses in previously treated waldenström's macroglobulinemia
  S. Treon, Boston, MA (USA)
16:10078The novel dual PI3K/MTOR inhibitor PQR309 shows preclinical activity as single agent or in combination and targets central signaling pathways in B-cell lymphomas
  C. Tarantelli, Bellinzona (Switzerland)
16:25079Phase 1 study of PI3Kδ inhibitor INCB040093 alone or in combination with selective JAK1 inhibitor INCB039110 in patients with relapsed/refractory B-cell malignancies
  T.J. Phillips, Ann Arbor, MI (USA)
16:40080A first-in-human trial of CUDC-907, an oral, first-in-class, dual inhibitor of PI3K and HDAC, in patients with refractory/relapsed lymphoma and multiple myeloma
  A. Younes, New York, NY (USA)
17:15–18:15 6 parallel sessions ‘FOCUS ON…’ SESSIONS
Room A Imaging
  Chair: B.D. Cheson, Washington, DC (USA)
17:15081Use of the lugano classification criteria for PET/CT assessment of primary mediastinal B-CELL lymphoma after immunochemotherapy and irradiation in the IELSG-26 study
  L. Ceriani, Bellinzona (Switzerland)
17:25082PET score following 3 cycles ABVD has greater prognostic value than pre-treatment risk stratification in the rapid trial in early stage hodgkin lymphoma (HL)
  J. Radford, Manchester (UK)
17:35083Baseline total metabolic volume (TMTV0) predicts the outcome of patients with diffuse large B-cell lymphoma (DLBCL) enrolled in the LNH07-3B LYSA trial
  O. Casasnovas, Créteil (France)
17:45084Prognostic value of baseline total metabolic tumour volume (TMTV0) measured on FDG-PET/CT in patients with peripheral T-cell lymphoma (PTCL)
  A. Cottereau, Rouen (France)
17:55085Little value of routine surveillance imaging for primary CNS lymphomas in first remission: results from a danish multicenter study
  K. Juul Mylam, Odense (Denmark)
18:05086Routine imaging for diffuse large B-CELL lymphoma in first remission is not associated with better survival: a danish–swedish population-based study
  T.C. El-Galaly, Aalborg (Denmark)
Room B Targetting CD30
  Chair: P. Borchmann, Cologne (Germany)
17:15087Brentuximab vedotin plus AVD for non-bulky limited stage classical hodgkin lymphoma: a Phase 2 trial
  J.S. Abramson, Boston, MA (USA)
17:25088Preliminary efficacy and safety of brentuximab vedotin and AVD chemotherapy followed by involved-site radiotherapy in early stage, unfavorable risk hodgkin lymphoma
  A. Kumar, New York, NY (USA)
17:35089Sequential brentuximab vedotin and AVD for older hodgkin lymphoma patients: initial results from a Phase 2 multicenter study
  A.M. Evens, Boston, MA (USA)
17:45090A Phase 1 study of brentuximab vedotin (BV) and bendamustine (B) in relapsed or refractory hodgkin lymphoma (HL) and anaplastic large T-cell lymphoma (ALCL)
  J. Kuruvilla, Toronto, ON (Canada)
17:55091Brentuximab vedotin demonstrates antitumor activity in CD30+ DLBCL
  M.R. Smith, Boston, MA (USA)
18:05092Updated results of a Phase 2 trial of brentuximab vedotin combined with RCHOP in frontline treatment of pts with high-intermediate/high-risk DLBCL
  S.M. Ansell, Rochester, MN (USA)
Room C Epidemiology and infections
  Chair: L. Arcaini, Pavia (Italy)
17:15093International dlbcl study finds biological heterogeneity between ethnically diverse countries but similar IPI-adjusted outcomes
  R. Carr, London (UK)
17:25094Involvement of moraxella catarrhalis in the pathogenesis of hodgkin lymphoma (nodular lymphocyte predominant type, IGD-positive)
  S. Hartmann, Frankfurt (Germany)
17:35095EPSTEIN-BARR virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival
  C. Visco, Vicenza (Italy)
17:45096Exposure to hepatitis B virus (HBV), family history, and B-CELL non-hodgkin lymphoma (B-NHL): a case-control study among Jews and Arabs in Israel and the West bank
  O. Paltiel, Jerusalem (Israel)
17:55097EBV positive dlbcl of the elderly is a heterogeneous disorder with outcome predicted by its immune microenvironment
  C. Keane, Brisbane (Australia)
18:05098The role of HBV-infection in chronic lymphocytic leukemia
  W. Xu, Nanjing (China)
Cinema Corso Management of T-cell lymphoma
  Chair: F. d'Amore, Aahrus (Denmark)
17:15099CHOEP VS. CHOP gives better results in first-line therapy of T-cell lymphoma. A retrospective analysis from Czech lymphoma study group (CLSG) databse
  A. Janikova, Brno (Czech Republic)
17:25100Long-term outcome of adults with ALCL after the first relapse/progression: A LYSA study
  D. Sibon, Paris (France)
17:35101Prospective Phase II trial of lenalidomide in association with chop in elderly patients with angioimmunoblastic T-cell lymphoma (AITL): interim analysis of a LYSA study
  V. Safar, Lyon (France)
17:45102Clinical outcomes and prognostic factors of up-front autologous stem cell transplantation in patients with extranodal NK/T-cell lymphoma
  H. Yhim, Jeonju (Korea)
17:55103P-GEMOX regimen followed by extensive involved-field radiotherapy for newly diagnosed Stage I/II ENKTL
  H. Hui-Qiang, Guangzhou (China)
18:05104HDAC inhibitor combinations exhibit synergy in pre- and clinical experiences in drug resistant T-cell lymphoma
  O.A. O'Connor, New York, NY (USA)
Auditorium, University Campus New drug combinations
  Chair: J.P. Leonard, New York, NY (USA)
17:15105Ublituximab (TG-1101), a novel glycoengineered anti-CD20 MAB, in combination with ibrutinib achieves 95% orr in patients with high-risk relapsed/?refractory CLL
  J. Burke, Aurora, CO (USA)
17:25106The chemotherapy-free triplet of ublituximab, TGR-1202, and ibrutinib is safe and highly active in relapsed B-cell malignancies
  L. Nastoupil, Houston, TX (USA)
17:35107A Phase 1 study of PI3Kδ inhibitor INCB040093 alone or in combination with selective JAK1 inhibitor INCB039110 in patients with relapsed/?refractory hodgkin lymphoma
  A. Forero-Torres, Birmingham, AL (USA)
17:45108ABT-199 triggers apoptosis, and augments ibrutinib cytotoxicity in CXCR4 wild-type and whith mutated waldenstroem macroglobulinemia cells
  J.J. Castillo, Boston, MA (USA)
17:55109Venetoclax (ABT-199/GDC-0199) in combination with bortezomib and dexamethasone in relapsed/?refractory multiple myeloma: Phase 1B results
  A.A. Chanan-Khan, Jacksonville, FL (USA)
18:05110Cancer energy metabolism as a therapeutic target in refractory MYC+ diffuse large B-CELL lymphoma
  C. Thieblemont, Paris (France)
Aula Magna, University Campus Ongoing trials
  Chair: A. Davies, Southampton (UK)
17:15OT01The IELSG-37 study: a randomized trial assessing the role of mediastinal radiotherapy after front-line rituximab and anthracycline containing regimens in patients with primary mediastinal large B-cell lymphoma (PMLBCL)
  M. Martelli, Rome (Italy)
17:25OT02Rochop study: a Phase III randomized study of chop compared to romidepsin-chop in untreated peripheral T-cell lymphoma
  R. Delarue, Paris (France)
17:35OT03CLL2-BIG, -BAG, -BCG AND -BIO: Four Phase-II trials evaluating a sequential tailored and targeted regimen aiming for total eradication of MRD in an all-comer CLL population
  P. Cramer, Cologne (Germany)
17:45OT04Phase 2 study of venetoclax (GDC-0199/ABT-199) plus bendamustine and rituximab (BR) vs. BR or venetoclax plus rituximab in relapsed/refractory FL
  W. Hiddemann, Munich (Germany)
17:55OT05DLC-002 (ROBUST): Phase III randomized, efficacy and safety study of lenalidomide plus R-chop vs R-chop in patients with untreated ABC-type diffuse large B-cell lymphoma
  A. Chiappella, Turin (Italy)
18:05OT06Randomized, multicenter, open-label, Phase 3 study of ibrutinib/?obinutuzumab vs. chlorambucil/obinutuzumab for treatment-naïve CLL/SLL (PCYC-1130; ILLUMINATE)
  C. Moreno, Barcelona (Spain)
Friday, June 19, 2015
08:30–18:30 Marquee POSTER SESSION
08:00–08:45 5 parallel sessionsArticle numberMEET THE PROFESSOR SESSIONS image
Room AI.Hodgkin lymphoma: special challenges and solutions
  J. M. Connors, Vancouver, British Columbia (Canada)
Room BII.Challenges in the management of PTLD
  G. Gaidano, Novara (Italy)
Cinema CorsoIX.Is it only about myc? how to approach the diagnosis of diffuse large B-cell lymphomas
  L. Quintanilla-Martinez, Tuebingen (Germany)
Auditorium, University CampusVIII.Treatment of CLL, where are we heading?
  S.M. O'Brien, Irvine, CA (USA)
Aula Magna, University CampusVI.FDG-pet as a biomarker in lymphoma: from qualitative to quantitative analysis
  M. Meignan, Creteil (France)
09:00–10:35 Room A and Marquee (overflow area)Abstract numberSESSION 7 - LYMPHOMA BIOLOGY AND GENOMICS II
  Co-Chairs: T.M. Mak, Toronto, ON (Canada) and L. Pasqualucci, New York, NY (USA)
09:00111Isocitrate dehydrogenase (IDH) mutations in angioimmunoblastic T-cell lymphoma (AITL)
  T.M. Mak Toronto, ON (Canada)
09:20112Recurrent mutations in TCR (pathway)-related genes in TFH-derived peripheral T-cell lymphomas
  D. Vallois, Lausanne (Switzerland)
09:35113HBZ, BCL-XL, AKT, and loss of INK4A/ARF synergistically transform primary murine T-cells and elicit ATL-like disease in mice
  Y. Kasugai, Nagoya (Japan)
09:50114Whole genome sequencing in the framework of ICGC MMML-SEQ identifies PCBP1 as recurrently mutated in burkitt lymphoma
  S.M. Aukema, Kiel (Germany)
10:05115Gene, mirna and pathway specific protein expression analysis in newly diagnosed MYC/BCL2 double expressing diffuse large B-cell lymphoma
  E. Matsuki, New York, NY (USA)
10:20116Mechanisms of malignant transformation in TP53 wild-type burkitt lymphoma identified by integration of molecular and functional genomics data
  J. Hüllein, Heidelberg (Germany)
09:00–10:30 5 parallel sessions ‘CASE DISCUSSION’ SESSIONS
Room B Aggressive lymphoma
  Chair: A. Lopez-Guillermo, Barcelona (Spain)
  Discussants: U. Vitolo, Turin (Italy) and P. Hamlin, New York, NY (USA)
Room C Lymphoma radiotherapy
  Chair: L. Specht, Copenhagen (Denmark)
  Discussants: U. Ricardi, Turin (Italy) and J. Yahalom, New York, NY (USA)
Cinema Corso Multiple myeloma
  Chair: S.V. Rajkumar, Rochester, MN (USA)
  Discussants: M. Cavo, Bologna (Italy) and M. Coleman, New York, NY (USA)
Auditorium, University Campus Mantle cell lymphoma
  Chair: S. Le Gouill, Nantes (France)
  Discussants: M. Martelli, Rome (Italy) and P. Martin, New York, NY (USA)
Aula Magna, University Campus Clinico-pathological discussion: border-line cases*
  Chair: M. Ghielmini, Bellinzona (Switzerland)
  Presenters: S. Dirnhofer, Basel (Switzerland), E. Campo, Barcelona (Spain) and S.H. Swerdlow, Pittsburgh, PA (USA)
  Discussants – M. Federico, Modena (Italy) and C.H. Moskowitz, New York, NY (USA)
  *supported by an unrestricted grant by sigma-tau Research Switzerland SA
10:30–11:00 Marquee COFFEE BREAK
11:00–12:05 Room A, B and Marquee (overflow area) SESSION 8 – HODGKIN'S LYMPHOMA
  Co-Chairs: R. Küppers, Essen (Germany) and J.A. Radford, Manchester (UK)
11:00117Introduction: Biology of Hodgkin lymphoma
  R. Küppers, Essen (Germany)
11:20118Interim pet-adapted chemotherapy in advanced hodgkin lymphoma (HL). Results of the second interim analysis of the Italian GITIL/FIL DH0607 trial
  A. Gallamini, Nice (France)
11:35119Interim pet response-adapted therapy in advanced stage hodgkin's lymphoma: Final results of the Phase II part of the fondazione italiana LINFOMI (FIL) HD0801 study
  P.L. Zinzani, Bologna (Italy)
11:50120Analysis of primary-refractory hodgkin lymphoma pts in a randomized, placebo-controlled study of brentuximab vedotin consolidation after autologous stem cell transplant
  C.H. Moskowitz, New York, NY (USA)
12:05–13:00 Room E 13-ICML PRESS CONFERENCE
  (open to all journalists)
12:05–13:00 Marquee LUNCH TIME AND POSTER VIEWING
  from 12:30 to 13:00 authors in front of their posters for discussion with attendees
13:00–13:50 Room A, B and Marquee (overflow area) JOHN ULTMANN MEMORIAL LECTURE* image
  Chair: E.S. Jaffe, Bethesda, MD (USA)
  *sponsored by European School of Oncology – ESO
 003Thirty years of progress in cutaneous lymphoma research
  R. Willemze, Leiden (The Nederlands)
13:50–15:20 Room A, B and Marquee SESSION 9 – INDOLENT LYMPHOMA
  Co-Chairs: B.S. Kahl, Madison, WI (USA) and A. Lopez-Guillermo, Barcelona (Spain)
13:50 13-ICML WORKSHOP REPORT
  R.D. Gascoyne, Vancouver, BC (Canada)
14:05121Risk of transformation of follicular lymphoma and outcome in the immunochemotherapy era: ancillary study from the prima trial
  C. Sarkozy, Pierre Bénite (France)
14:20122Complete response rate at 30 months (CR30) as a surrogate endpoint in first-line follicular lymphoma: a prospectively specified analysis using individual patient data
  D.J. Sargent, Rochester, MN (USA)
14:35123Gadolin: primary results of a Phase III study of obinutuzumab plus bendamustine compared with bendamustine alone in patients with rituximab-refractory indolent lymphoma
  B.D. Cheson, Washington, D.C. (USA)
14:50124A simple and effective malt lymphoma-specific prognostic index generated from the dataset of the IELSG-19 controlled clinical trial
  C. Thieblemont, Paris (France)
15:05125BING-NEEL syndrome: a multi-institutional retrospective study
  J.J. Castillo, Boston, MA (USA)
15:20–15:40 BREAK
15:40–16:15 Room A, B and Marquee (overflow area) CONTROVERSY
  Early-stage HL: should interim pet-based therapy be considered routine clinical practice?
  Chair: T.A. Lister, London (UK)
 006NO: M. Hutchings, Copenhagen (Denmark) vs
 007YES: J.M. Connors, Vancouver, British Columbia (Canada)
16:15–17:45 Room A, B and Marquee (overflow area) SESSION 10 – AGGRESSIVE LYMPHOMA
  Co-Chairs: U. Vitolo, Turin (Italy) and L.H. Sehn, Vancouver, BC (Canada)
16:15126Gray zone lymphoma (GZL): characteristics, outcomes and prognostication among a large multicenter cohort
  A.M. Evens, Boston, MA (USA)
16:30127Ratios of T-cells to tumour associated macrophages and PD-1 axis molecules, add to the predictive power of conventional prognosticators in diffuse large B-cell lymphoma
  M. Gandhi, Brisbane (Australia)
16:45128Continued risk of relapse independent of treatment modality in limited stage diffuse large B-CELL Lymphoma: final and long-term analysis of SWOG study S8736
  D.M. Stephens, Salt Lake City, UT (USA)
17:00129Treatment selection and survival outcomes in early-stage diffuse large B-cell lymphoma: Does modern chemotherapy replace the need for radiotherapy?
  J.A. Vargo, Pittsburg, PA (USA)
17:15130Front line therapy with R-CODOX-M & R-IVAC in poor risk diffuse large B-cell lymphoma (IPI 3-5) yields a good outcome without transplantation: a Phase 2 UK NCRI/LLR trial
  A.K. McMillan, Nottingham (UK)
17:30131Validation of the german high-grade non-hodgkin lymphoma study group (DSHNHL) prognostic model for CNS relapse in a large cohort of PET/CT staged patients
  T.C. El-Galaly, Aalborg (Denmark)
17:45 Marquee FAREWELL APERO
Saturday, June 20, 2015
08:00–10:30 Room 159, University Campus SPECIAL SESSION - CONTOURING IN MODERN LYMPHOMA RADIOTHERAPY PLANNING*
  A. Kiil Berthelsen, Copenhagen (Denmark), S. Qi, New York, NY (USA) and Beijing (China) and L. Specht, Copenhagen (Denmark)
  Organized by International Lymphoma Radiation Oncology Group – ILROG and European Society for Radiotherapy and Oncology – ESTRO
  * compulsory pre-registration
08:30–10:00 2 parallel sessions  
Room A SESSION 11 – PRIMARY CNS LYMPHOMA
  Co-Chairs: G. Illerhaus, Stuttgart (Germany) and A.J. Ferreri, Milan (Italy)
08:30132High frequency of MYD88 mutations in vitreoretinal B-cell lymphoma: a valuable tool to improve diagnostic yield of vitreous body aspirates
  I. Bonzheim, Tuebingen (Germany)
08:45133Genetic basis of primary central nervous system lymphoma
  K. Yoshida, Kyoto (Japan)
09:00134Rituximab, methotrexate, procarbazine and lomustine for elderly primary CNS lymphoma patients – the primain-study by the german cooperative PCNSL group
  B. Kasenda, Stuttgart (Germany)
09:15135Management and outcome of primary cns lymphoma at first relapse/progression: Analysis of 256 patients from the French LOC network
  S. Langner-Lemercier, Rennes (France)
09:30136Phase I/II study of TEDDI-R with ibrutinib in untreated and relapsed/refractory primary CNS lymphoma
  K. Dunleavy, Bethesda, MD (USA)
09:45137Lenalidomide is highly active in recurrent cns lymphomas: Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide as maintenance monotherapy
  J.L. Rubenstein, San Francisco, CA (USA)
08:40–10:00 Room B SESSION 12 – IMMUNOTHERAPY
  Co-Chairs: R. Levy, Stanford, CA (USA) and F. Morschhauser, Lille (France)
08:40138Introduction: Immunotherapy of lymphoma 2015
  R. Levy, Stanford, CA (USA)
09:00139Phase II trial of chimeric antigen receptor modified T-cells directed against CD19 in relapsed/refractory diffuse large B-cell, follicular, and mantle cell lymphomas
  S.J. Schuster, Philadelphia, PA (USA)
09:15140A Phase II a study of single-agent MOR208, an FC-optimized anti-CD19 antibody, in patients with relapsed or refractory B-cell non-hodgkin's lymphoma
  P.L. Zinzani, Bologna (Italy)
09:30141Phase I, first-in-human trial of BI 836826 (an anti-CD37 antibody) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
  S. Stilgenbauer, Ulm (Germany)
09:45142Two doses of polatuzumab vedotin in patients with relapsed/?refractory (R/R) follicular lymphoma (FL): durable responses at lower dose
  F. Morschhauser, Lille (France)
10:00–11:20 Room A and B SESSION 13 – TARGETTING INTRACELLULAR PATHWAYS
  Co-Chairs: M. Seto, Nagoya (Japan) and J.F. Seymour, Melbourne (Australia)
10:00143Introduction: Genetic and epigenetic heterogeneity of malignant lymphoma: challenging features
  M. Seto, Nagoya (Japan)
10:20144Epigenetic control of cellular senescence in tumor development and lymphoma treatment
  C.A. Schmitt, Berlin (Germany)
10:35145Phase 1 study of E7438 (EPZ-6438), an enhancer of ZESTE-HOMOLOG 2 (EZH2) inhibitor: dose determination and preliminary activity in non-hodgkin lymphoma
  V. Ribrag, Villejuif (France)
10:50146Selinexor shows activity in double-hit diffuse large B-cell lymphoma in pre-clinical models and in-patients with relapsed/?refractory double-hit DLBCL
  R. Garzon, Columbus, OH (USA)
11:05147Phase 1 preliminary safety, efficacy and biomarker data from venetoclax (ABT-199/GDC-0199) + bendamustine and rituximab in R/R non-hodgkin's lymphoma
  S. de Vos, Los Angeles, CA (USA)
11:20–11:45 Room A and B 13-ICML HIGHLIGHTS image
  TAKE HOME MESSAGES
  J.W. Friedberg, Rochester, NY (USA)
11:45–11:55 CLOSURE AND FAREWELL
  F. Cavalli, Bellinzona (Switzerland)
13:30–18:00 Room B WORKSHOP: ‘CANINE LYMPHOMAS: STATE OF THE ART AND COMPARATIVE ASPECTS WITH HUMAN DISEASE’*
  Co-Chairs: S. Comazzi, Milan (Italy), F. Guscetti, Zurich (Switzerland) and L. Marconato, Bologna (Italy)
  Organized by the European Canine Lymphoma Group
  *open to all 13-ICML attendees

imageThis icon denotes presentations that will be available online, only for 13-ICML attendees, between July 15 and September 15, 2015.

Please note that this version of the program (last updated on May 08, data of printing) may differ from the final program. Changes communicated to 13-ICML Secretariat after this date could not be included.

EDUCATIONAL BOOK

LIST OF MEET THE PROFESSOR ARTICLES:

  • I.Hodgkin Lymphoma: Special Challenges and SolutionsJoseph M. Connors, Vancouver, BC (Canada)
  • II.Challenges in the management of PTLDGianluca Gaidano, Novara (Italy)
  • III.Current Concepts in Primary Central Nervous LymphomaGerald Illerhaus, Stuttgart (Germany)
  • IV.Masses in the Mediastinum: Primary Mediastinal Lymphoma and Intermediate TypesPeter M.W. Johnson, Southampton (UK)
  • V.Smoldering Multiple MyelomaMaria-Victoria Mateos, Salamanca (Spain)
  • VI.FDG-PET as a Biomarker in Lymphoma: from Qualitative to Quantitative AnalysisMichel Meignan, Creteil (France)
  • VII.Are lymphomas driven by epigenetic lesions?Ari M. Melnick, New York, NY (USA)
  • VIII.Treatment of CLL, where are we heading?Susan M. O'Brien, Irvine, CA (USA)
  • IX.Is it only about MYC? How to approach the diagnosis of Diffuse Large B-Cell LymphomasLeticia Quintanilla-Martinez, Tuebingen (Germany)
  • X.Challenges and Future Directions in Peripheral T-Cell LymphomaKerry J. Savage, Vancouver, BC (Canada)
  • XI.Management of pediatric and adult non-Hodgkin lymphoma: what lessons can each teach the other?Birgit Burkhardt, Muenster (Germany) and John F. Seymour, Melbourne (Australia)
  • XII.Therapeutic Exploitation of Autologous T-Cell Activation in B-Cell LymphomaAnas Younes, New York, NY (USA)

LIST OF EDUCATIONAL SYMPOSIA ARTICLES:

  • XIII.Molecular pathogenesis of transformed lymphomasDavide Rossi, Novara (Italy)
  • XIV.The pathology of transformation of lymphomaRandy D. Gascoyne, Vancouver, BC (Canada)
  • XV.Clinical aspects of transformed lymphomaJohn G. Gribben, London (UK)
  • XVI.Early stage Hodgkin lymphomaJohn A. Radford, Manchester (UK)
  • XVII.Treatment of advanced-stage Hodgkin lymphomaAndreas Engert, Cologne (Germany)
  • XVIII.Management of nodular lymphocyte predominant Hodgkin lymphomaRanjana H. Advani, Stanford, CA (USA)

Note: The articles published in the 13-ICML Educational Book represent the presentations made at the “Meet the Professor” sessions and “Educational Symposia” during the 13th International Conference on Malignant Lymphoma (13-ICML) held in Lugano, Switzerland on June 17–20, 2015.

All manuscripts submitted have been subjected to peer review, and authors have been requested to disclose any relationships with the companies whose products or services are discussed in their manuscripts.

Prof Michele Ghielmini, as guest editor, has reported no financial relationships with companies whose products are mentioned in this supplement.

13-ICML Reviewers' List

The 13-ICML Local Organizing Committee wishes to thank the following colleagues for their professional help:

  • S.M. Ansell, Rochester, MN (USA)
  • J.O. Armitage, Omaha, NE (USA)
  • T.T. Batchelor, Boston, MA (USA)
  • P. Boffetta, New York, NY (USA)
  • E. Campo, Barcelona (Spain)
  • L. Ceriani, Bellinzona (Switzerland)
  • B.D. Cheson, Washington, DC (USA)
  • J.M. Connors, Vancouver, BC (Canada)
  • F.E. Cotter, London (UK)
  • R. Dalla-Favera, New York, NY (USA)
  • A. Davies, Southampton (UK)
  • L.M. DeAngelis, New York, NY (USA)
  • M.A. Dimopoulos, Athens (Greece)
  • S. Dirnhofer, Basel (Switzerland)
  • R. Dolcetti, Aviano (Italy)
  • M. Dreyling, Munich (Germany)
  • K. Dunleavy, Bethesda, MD (USA)
  • A. Engert, Cologne (Germany)
  • M. Federico, Modena (Italy)
  • A.J. Ferreri, Milan (Italy)
  • M.F. Fey, Bern (Switzerland)
  • F. Forconi, Southampton (UK)
  • F. Foss, New Haven, CT (USA)
  • J.W. Friedberg, Rochester, NY (USA)
  • A. Gallamini, Nice (France)
  • R.D. Gascoyne, Vancouver BC (Canada)
  • P. Gaulard, Créteil (France)
  • M.K. Gospodarowicz, Toronto Ontario (Canada)
  • M. Hallek, Cologne (USA)
  • O.R. Hermine, Paris (France)
  • M. Hutchings, Copenhagen (Denmark)
  • E.S. Jaffe, Bethesda, MD (USA)
  • P.W.M. Johnson, Southampton (USA)
  • R. Küppers, Essen (Germany)
  • J.P. Leonard, New York, NY (USA)
  • R. Levy, Stanford, CA (USA)
  • T.A. Lister, London (UK)
  • A. Lopez-Guillermo, Barcelona (Spain)
  • S. Luminari, Modena (Italy)
  • M.V. Mateos, Salamanca (Spain)
  • M. Meignan, Créteil (France)
  • M. Crump, Toronto, ON (Canada)
  • S. Montoto, London (UK)
  • G.S. Nowakowski, Rochester, MN (USA)
  • S.M. O'Brien, Irvine, CA (USA)
  • L. Pasqualucci, New York, NY (USA)
  • M. Pillon, Padua (Italy)
  • M.A. Piris, Santander (Spain)
  • J. Radford, Manchester (UK)
  • S.V. Rajkumar, Rochester, MN (USA)
  • U. Ricardi, Turin (Italy)
  • D. Rossi, Novara (Italy)
  • G. Salles, Pierre Bénite (France)
  • M. Seto, Nagoya (Japan)
  • J.F. Seymour, Melbourne (Australia)
  • M.A. Shipp, Boston, MA (USA)
  • L. Specht, Copenhagen (Denmark)
  • M. Spina, Aviano (Italy)
  • L.M. Staudt, Bethesda, MD (USA)
  • C. Thieblemont, Paris (France)
  • K. Tobinai, Tokyo (Japan)
  • R. Tsang, Toronto, Ontario (Canada)
  • U. Vitolo, Turin (Italy)
  • J.M. Vose, Omaha, NE (USA)
  • M. Weller, Zurich (Switzerland)
  • W. Wössmann, Giessen (Germany)
  • K.H. Young, Houston, TX (USA)
  • A. Younes, New York, NY (USA)
  • P.L. Zinzani, Bologna (Italy)

Ancillary