Presented in part at the Annual Meeting of the American Society of Hematology, December 1984.
Long-term results of treatment of patients with follicular lymphomas†
Article first published online: 2 MAR 2007
Copyright © 1987 John Wiley & Sons, Ltd
Volume 5, Issue 2, pages 127–138, April 1987
How to Cite
Kalter, S., Holmes, L. and Cabanillas, F. (1987), Long-term results of treatment of patients with follicular lymphomas. Hematol. Oncol., 5: 127–138. doi: 10.1002/hon.2900050207
- Issue published online: 2 MAR 2007
- Article first published online: 2 MAR 2007
- Manuscript Received: 23 JAN 1987
- Follicular lymphoma
The management of patients with follicular lymphoma is controversial, particularly in those with follicular small cleaved cell (FSCC) or nodular poorly differentiated lymphoma (NPDL). Some advocate no treatment until symptoms arise, while others prefer to treat with intensive combination regimens and others with single agents. We reviewed the long-term effects of two types of combination chemotherapy on relapse-free survival and survival on 91 patients (88 were stages III–IV) who had received no previous chemotherapy. Those patients with FSCC lymphoma obtaining a complete remission had a significantly longer median survival than did those obtaining a partial remission (13 years versus 2 years). An adriamycin-containing regimen appeared to be the key factor in obtaining a complete remission in FSCC after taking into consideration prognostic factors. Not only was the complete response rate significantly higher for patients receiving adriamycin, but so too was the median survival and relapse-free survival. BCG immunotherapy appeared to be important in preventing relapse in some of the complete responders with NPDL who received adriamycin.