Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake
Article first published online: 26 MAY 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Volume 24, Issue 3, pages 146–150, September 2006
How to Cite
Hutchings, M., Loft, A., Hansen, M., Ralfkiaer, E. and Specht, L. (2006), Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake. Hematol. Oncol., 24: 146–150. doi: 10.1002/hon.782
- Issue published online: 31 AUG 2006
- Article first published online: 26 MAY 2006
- Manuscript Accepted: 30 MAR 2006
- Manuscript Revised: 13 MAR 2006
- Manuscript Received: 31 DEC 2005
- Hodgkin lymphoma;
Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUVmax/total) and in each affected region or organ (SUVmax) were recorded. Mean SUVmax/total was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUVmax was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL. Copyright © 2006 John Wiley & Sons, Ltd.