Extranodal NK/T-cell lymphoma: diagnosis and treatment cues
Article first published online: 19 FEB 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Volume 26, Issue 2, pages 66–72, June 2008
How to Cite
Suzuki, R., Takeuchi, K., Ohshima, K. and Nakamura, S. (2008), Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol. Oncol., 26: 66–72. doi: 10.1002/hon.847
- Issue published online: 28 MAY 2008
- Article first published online: 19 FEB 2008
- Manuscript Accepted: 31 DEC 2007
- Manuscript Revised: 9 DEC 2007
- Manuscript Received: 19 JUN 2007
- natural killer cell;
- azurophilic granule;
- Epstein–Barr virus;
- cytotoxic molecule
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia. It predominantly occurs in the nasal or paranasal areas and less frequently in the skin. Most of the tumours show NK-cell, but rarely T-cell, phenotypes. The Epstein–Barr virus (EBV) genome can be usually detected in lymphoma cells. Geographic localization of ENKL matches the endemic distribution of EBV, suggesting that EBV plays an important role in lymphomagenesis. Originally, NK-cell and T-cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK-cell phenotype. Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p-glycoprotein. Therefore, new therapeutic approaches must be considered. Several new clinical trials are now being conducted in East Asia. Copyright © 2008 John Wiley & Sons, Ltd.