Review Article

The therapeutic potential of the proteasome in leukaemia†

  1. Scott Marshall McCloskey1,*,
  2. Mary Frances McMullin2,
  3. Brian Walker3,
  4. Alexandra E Irvine1

Article first published online: 6 MAR 2008

DOI: 10.1002/hon.848

Issue

Hematological Oncology

Hematological Oncology

Volume 26, Issue 2, pages 73–81, June 2008

Additional Information

How to Cite

McCloskey, S. M., McMullin, M. F., Walker, B. and Irvine, A. E. (2008), The therapeutic potential of the proteasome in leukaemia. Hematol. Oncol., 26: 73–81. doi: 10.1002/hon.848

Author Information

  1. 1

    CCRCB, Queen's University of Belfast, Belfast, Northern Ireland

  2. 2

    Department of Haematology, Queen's University of Belfast, Belfast, Northern Ireland

  3. 3

    School of Pharmacy, Queen's University of Belfast, Belfast, Northern Ireland

*CCRCB, Queen's University of Belfast, G Floor, Belfast, Northern Ireland.

  1. †

    There have been no other submissions of this review or duplications of this work. There are no conflicts of interest. This manuscript is a review of already published and ethically approved research.

Publication History

  1. Issue published online: 28 MAY 2008
  2. Article first published online: 6 MAR 2008
  3. Manuscript Revised: 18 JAN 2008
  4. Manuscript Accepted: 18 JAN 2008
  5. Manuscript Received: 30 OCT 2007

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Keywords:

  • leukaemia;
  • bortezomib;
  • proteasome

Abstract

Many cellular processes converge on the proteasome, and its key regulatory role is increasingly being recognized. Proteasome inhibition allows the manipulation of many cellular pathways including apoptotic and cell cycle mechanisms. The proteasome inhibitor bortezomib has enhanced responses in newly diagnosed patients with myeloma and provides a new line of therapy in relapsed and refractory patients. Malignant cells are more sensitive to proteasome inhibition than normal haematopoietic cells. Proteasome inhibition enhances many conventional therapies and its role in leukaemia is promising. Copyright © 2008 John Wiley & Sons, Ltd.

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