p53 Review Article

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TP53 and head and neck neoplasms†

  1. Hélène Blons1,
  2. Pierre Laurent-Puig1,2,*

Article first published online: 24 FEB 2003

DOI: 10.1002/humu.10171

Issue

Human Mutation

Human Mutation

Special Issue: Focus on p53 and Cancer

Volume 21, Issue 3, pages 252–257, March 2003

Additional Information

How to Cite

Blons, H. and Laurent-Puig, P. (2003), TP53 and head and neck neoplasms. Hum. Mutat., 21: 252–257. doi: 10.1002/humu.10171

Author Information

  1. 1

    U490 INSERM Laboratoire de Toxicologie Moléculaire, Paris, France

  2. 2

    Service de chirurgie digestive générale et oncologique, Assistance Publique Hôpitaux de Paris, Hôpital Georges Pompidou 20, Paris, France

*U490 INSERM, Laboratoire de Toxicologie Moléculaire, 45 rue des Saints Pères 75006 Paris, France

  1. †

    For the p53 Special Issue

Publication History

  1. Issue published online: 24 FEB 2003
  2. Article first published online: 24 FEB 2003

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Keywords:

  • p53;
  • TP53;
  • cancer;
  • tumor;
  • neoplasm;
  • head;
  • neck;
  • squamous cell carcinoma;
  • tobacco;
  • alcohol;
  • carcinogen

Abstract

Head and neck cancer is an important health problem around the world, accounting for approximately 500,000 new cases each year of head and neck squamous cell carcinoma (HNSCC). Carcinogenesis of head and neck results from a dysregulation of cellular proliferation, differentiation, and cell death. The major etiologic agents are tobacco and alcohol consumption and for some cases, human papilloma virus (HPV) infection. All three factors are associated with the disruption of a cellular pathway essential for the maintenance of cellular integrity, the p53 pathway. The objective of this review is to point out the specificity of p53 gene (TP53) alterations in head and neck cancer in relation with chemocarcinogenesis and to discuss whether or not the determination of p53 alterations will be of clinical relevance in the management of head and neck cancer in terms of prognosis and response to treatments. Hum Mutat 21:252–257, 2003. © 2003 Wiley-Liss, Inc.

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