For the p53 Special Issue
p53 Review Article
TP53 and head and neck neoplasms†
Article first published online: 24 FEB 2003
© 2003 Wiley-Liss, Inc.
Special Issue: Focus on p53 and Cancer
Volume 21, Issue 3, pages 252–257, March 2003
How to Cite
Blons, H. and Laurent-Puig, P. (2003), TP53 and head and neck neoplasms. Hum. Mutat., 21: 252–257. doi: 10.1002/humu.10171
- Issue published online: 24 FEB 2003
- Article first published online: 24 FEB 2003
- squamous cell carcinoma;
Head and neck cancer is an important health problem around the world, accounting for approximately 500,000 new cases each year of head and neck squamous cell carcinoma (HNSCC). Carcinogenesis of head and neck results from a dysregulation of cellular proliferation, differentiation, and cell death. The major etiologic agents are tobacco and alcohol consumption and for some cases, human papilloma virus (HPV) infection. All three factors are associated with the disruption of a cellular pathway essential for the maintenance of cellular integrity, the p53 pathway. The objective of this review is to point out the specificity of p53 gene (TP53) alterations in head and neck cancer in relation with chemocarcinogenesis and to discuss whether or not the determination of p53 alterations will be of clinical relevance in the management of head and neck cancer in terms of prognosis and response to treatments. Hum Mutat 21:252–257, 2003. © 2003 Wiley-Liss, Inc.