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The TP53 gene, tobacco exposure, and lung cancer†
Article first published online: 24 FEB 2003
DOI: 10.1002/humu.10177
© 2003 Wiley-Liss, Inc.
Issue
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Human Mutation
Special Issue: Focus on p53 and Cancer
Volume 21, Issue 3, pages 229–239, March 2003
Additional Information
How to Cite
Toyooka, S., Tsuda, T. and Gazdar, A. F. (2003), The TP53 gene, tobacco exposure, and lung cancer. Hum. Mutat., 21: 229–239. doi: 10.1002/humu.10177
- †
Publication History
- Issue published online: 24 FEB 2003
- Article first published online: 24 FEB 2003
REFERENCES
- , , , , , , , , , , . 1999. Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer [see comments]. J Natl Cancer Inst 91:332–339.
- , , , , , , . 2000. Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer. Cancer Res 60:3155–3159.
- , , , . 2002. The proline-rich domain of p53 is required for cooperation with anti- neoplastic agents to promote apoptosis of tumor cells. Oncogene 21:9–21.
- , , , , , , , , , , et al. 1993a. p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res 53:4817–4822.
- , , , , , , , , , , , , , , , . 1993b. p53 protein accumalates frequently in early bronchial neoplasia. Cancer Res 53:4817–4822.
- , . 2003. The UMD-p53 database: new mutations and analysis tools. Hum Mutat 21:176–181.Direct Link:
- , . 2003. TP53 and head and neck neoplasms. Hum Mutat 21:252–257.Direct Link:
- , , , , , , , , , , . 1992. Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene 7:743–749.
- . 1996. P53 and angiogenesis. Biochim Biophys Acta 1287:63–66.
- , , . 2002. The pathogenesis of mesothelioma. Semin Oncol 29:2–17.
- , . 1992. TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomes Cancer 4:1–15.Direct Link:
- , , , , , , , . 2001. Gender difference in DNA adduct levels among nonsmoking lung cancer patients. Environ Mol Mutagen 37:304–310.Direct Link:
- , , , , , , , . 1997. Widely dispersed p53 mutation in respiratory epithelium. J Clin Invest 100:2133–2137.
- , , , , , . 1993. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res 53:4129–4133.
- , , , , , . 1994. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54:2287–2291.
- , , , , , , . 1997. Distribution of p53 and K-ras mutations in human lung cancer tissues. Carcinogenesis 18:473–478.
- , . 1998. p53 and angio-genesis in non-small-cell lung cancer. Br J Cancer 77:850–852.
- , , , , , , , , , , et al. 1995. Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression. Carcinogenesis 16:993–1002.
- , , . 2001. TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database. Mutagenesis 16:551–553.
- , . 2001. Patterns of p53 G→T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis 22:367–374.
- , . 2000. The hallmarks of cancer. Cell 100:57–70.
- . 1996. p53 tumor suppressor gene: from the basic research laboratory to the clinic: an abridged historical perspective. Carcinogenesis 17:1187–1198.
- . 2002. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol 3:461–469.
- , , , , , , , . 1998. Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs. J Surg Oncol 68:19–24.Direct Link:
- , , , , , , , , , . 1997. p53 gene mutation analysis in tumors of patients exposed to alpha- particles. Carcinogenesis 18:511–516.
- , , , , , . 1997. Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells. Carcinogenesis 18:121–125.
- , , , , , , , , , , . 2001a. Mutability of p53 hotspot codons to benzoapyrene diol epoxide BPDE and the frequency of p53 mutations in nontumorous human lung. Cancer Res 61:6350–6355.
- , , . 2001b. Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. Lung Cancer 34(Suppl 2):S7–S15.
- , , , . 1996. Identification of carcinoembryonic antigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction. Gut 39:717–721.
- , , , . 1994. Atypical alveolar hyperplasia: relationship with pulmonary adenocarcinoma, p53, and c-erbB-2 expression. J Pathol 174:249–256.Direct Link:
- , , , . 1998. Proliferative activity, p53 expression and loss of heterozygosity on 3p, 9p and 17p in atypical adenomatous hyperplasia of the lung. Hiroshima J Med Sci 47:17–25.
- , , , , , , , , , . 1995. Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma. Am J Pathol 146:876–887.
- , , , . 1999. Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am J Clin Pathol 111:610–622.
- , , , , . 2001. Prognostic significance of p53 and bcl-2 abnormalities in operable nonsmall cell lung cancer. Eur Respir J 17:660–666.
- , , , , . 1998. p53 gene mutations in asbestos associated cancers. Biomed Environ Sci 11:226–232.
- , , , , . 1994. Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Res 54:1634–1637.
- . 2001. Molecular abnormalities in lung carcinogenesis and their potential clinical implications. Lung Cancer 34(Suppl 2):S27–S34.
- , , . 1999. Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas. J Clin Pathol 52:291–293.
- , , , , . 1995. p53 and K-ras in radon-associated lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev 4:791–793.
- , , , . 1993. Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer [see comments]. Chest 104:362–365.
- , , , . 2000. Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis. Clin Cancer Res 6:4055–4063.
- , , , , , , , . 1997. Absence of p53 mutations in malignant mesotheliomas. Am J Respir Cell Mol Biol 16:9–13.
- , , , . 2001a. Expression of vascular endothelial growth factor VEGF in non-small cell lung cancer NSCLC: association with p53 gene mutation and prognosis. Lung Cancer 34(Suppl 2):S59–S64.
- , , , , . 2001b. Detection of P53 abnormalities in non-small cell lung cancer by yeast functional assay. Folia Histochem Cytobiol 39:147–148.
- , , , , , , , , , . 1999. Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clin Cancer Res 5:1015–1023.
- . 1955. Workbook of epidemiology. New York: University Press.
- , , , , , . 2002. The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19:607–614.Direct Link:
- , , , , , , , . 1999. Genetic changes in the spectrum of neuroendocrine lung tumors. Cancer 85:600–607.Direct Link:
- , , . 2001. Cancer burden in the year 2000. The global picture. Eur J Cancer 37(Suppl 8):4–66.
- . 2000. Analysis of different versions of the IARC p53 database with respect to G→T transversion mutation frequencies and mutation hotspots in lung cancer of smokers and non-smokers. Mutagenesis 15:457–458.
- . 2001. Reply to the contribution of Hainault, Olivier and Pfeifer TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database. Mutagenesis 16:555–556.
- . 2001. “Smoke like a man, die like a man?”: a review of the relationship between gender, sex and lung cancer. Soc Sci Med 53:1067–1080.
- , , , , , . 2000. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. Br Med J 321:323–329.
- , , , , , , , , , , . 2001. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 3:337–350.
- , . 2000. Human lung cancer and p53: the interplay between mutagenesis and selection. Proc Natl Acad Sci USA 97:12244–12249.
- , , , , , , , , , , , , , , , , , , , , , , , . 1996. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 2:985–991.
- , . 1998. Modern epidemiology. 2nd ed. Philadelphia: Lippincott-Raven Publisher.
- , , , , , , , . 1995. Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 55:5038–5042.
- , , , , , , , , , , , , , , , , , . 2001. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study. J Clin Oncol 19:1750–1758.
- , , , , , . 2000. Presence of simian virus 40 sequences in malignant pleural, peritoneal and noninvasive mesotheliomas. Int J Cancer 85:743–745.Direct Link:
- , , , , , , . 1998. p53 alterations in atypical alveolar hyperplasia of the human lung. Hum Pathol 29:801–808.
- , , , , , , . 2000. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J Natl Cancer Inst 92:803–811.
- , . 2001. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 1:233–240.
- , , , , , , , . 1992. Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res 52:6079–6082.
- , , , , , , , , , . 1989. p53: A frequent target for genetic abnormalities in lung cancer. Science 246:491–494.
- , , , , , , , , . 1991. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol 15:529–553.
- , , . 1995. Lung cancer. Cancer 75:191–202.Direct Link:
- , , , , , , , . 2001. p53 and K-ras mutations in lung cancers from former and never-smoking women. Cancer Res 61:4350–4356.
- . 2003. TP53 mutations in exposed workers. Hum Mutat 21:240–251.Direct Link:
- , , , , , . 2002. p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer. J Cancer Res Clin Oncol 128:141–147.
- , , , , , , , , . 1995. Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure. Cancer Epidemiol Biomarkers Prev 4:543–548.
- , , , , , , , , . 1999. German uranium miner study–pathological and molecular genetic findings. German uranium miner study, research group pathology. Radiat Res 152:S52–S55.
- , , , , , , , , . 1997. Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst 89:1366–1372.
- , , , , , , . 1999. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 18:643–650.
- , , , , , , , , . 2000. Molecular changes in the bronchial epithelium of patients with small cell lung cancer. Clin Cancer Res 6:2604–2610.
- , , , , , . 2000. Analysis of radon-associated squamous cell carcinomas of the lung for a p53 gene hotspot mutation. Br J Cancer 82:763–766.
- , , , , , . 2002. Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer. J Clin Oncol 20:900–910.
- , . 1996. Differences in lung cancer risk between men and women: Examination of the evidence. J Natl Cancer Inst 88:183–192.
- , , , , , . 1994. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1:5–13.

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