Communicated by Richard G. H. Cotton
Rapid Communication
You have free access to this content
Genetic variation in a haplotype block spanning IDE influences Alzheimer disease†
Article first published online: 24 SEP 2003
DOI: 10.1002/humu.10282
Copyright © 2003 Wiley-Liss, Inc.
Additional Information
How to Cite
Prince, J. A., Feuk, L., Gu, H. F., Johansson, B., Gatz, M., Blennow, K. and Brookes, A. J. (2003), Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. Hum. Mutat., 22: 363–371. doi: 10.1002/humu.10282
- †
Publication History
- Issue published online: 25 SEP 2003
- Article first published online: 24 SEP 2003
- Manuscript Accepted: 29 AUG 2003
- Manuscript Received: 11 AUG 2003
Funded by
- Pharmacia Corporation
- Swedish Medical Research Council
- Swedish Foundation for Strategic Research
- Knut and Alice Wallenberg Foundation
- AMF Jubileum Fund
- Tore Nilsons Foundation
- Loo and Hans Ostermans Foundation
- Swedish Old Servants Foundation (Gamla Tjänarinnor)
- Captain Arthur Erikssons Foundation
- Åke Wibergs Foundation
- Torsten and Ragnar Söderbergs Foundation
- Fredrik and Ingrid Thurings Foundation
- Swedish Alzheimer Foundation (Alzheimerfonden)
- NIA. Grant Numbers: R01-AG08724, AG08861
- Abstract
- References
- Cited By
Cited in:
- CrossRef
This article has been cited by:
- 1, , , , , , , , Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels, Neurobiology of Aging, 2012, 33, 1, 199.e13
- 2, , , , , , , , , , , , , , Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese, Neurobiology of Aging, 2012, 33, 5, 1014.e1
- 3, , , Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease, Biochemistry Research International, 2011, 2011, 1
- 4, , , , , , , , Genetic and biochemical studies of SNPs of the mitochondrial Aβ-degrading protease, hPreP, Neuroscience Letters, 2010, 469, 2, 204
- 5, , Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link?, Diabetologia, 2009, 52, 8, 1457
- 6, , , , , , , Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease, Ageing Research Reviews, 2009, 8, 3, 214
- 7, , Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease, Brain Research, 2009, 1249, 1
- 8, , , , , , , , , , , Evidence that the gene encoding insulin degrading enzyme influences human lifespan, Human Molecular Genetics, 2008, 17, 15, 2370
- You have free access to this content9, , , , , , SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease, Brain Pathology, 2008, 18, 2Direct Link:
- 10, , , , , , , , , , , , , Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease, Neuroscience Letters, 2007, 420, 3, 257
- 11, , , , , , , , , Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007, 144B, 4Direct Link:
- 12, , Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial functionârole of glucose metabolism and insulin signalling, Archives Of Physiology And Biochemistry, 2007, 113, 3, 131
- 13, Genetics of Alzheimer's Disease: A Centennial Review, Neurologic Clinics, 2007, 25, 3, 611
- 14, Genetics, Dementia, and the Elderly, Current Directions in Psychological Science, 2007, 16, 3, 123
- 15, , , , , , , Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE, Neurobiology of Aging, 2007, 28, 9, 1374
- 16, , , , , , , , , , Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures, Neurobiology of Aging, 2007, 28, 5, 727
- 17
- 18, , , , , Acute lung injury and the coagulation pathway: potential role of gene polymorphisms in the protein C and fibrinolytic pathways, Intensive Care Medicine, 2006, 32, 9, 1293
- 19, , , Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease, Neuroscience Letters, 2006, 406, 3, 265
- 20, , , , , <i>TAU</i> Haplotype and the <i>Saitohin</i> Q7R Gene Polymorphism Do Not Influence CSF Tau in Alzheimer’s Disease and Are Not Associated with Frontotemporal Dementia or Parkinson’s Disease, Neurodegenerative Diseases, 2005, 2, 1, 28
- 21, , , , , Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders, Neurobiology of Aging, 2005, 26, 5, 645
- 22, , , , , , , , , , , , , , , , , , , , , , , , , , , , Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005, 136B, 1Direct Link:
- 23, , Genetic association analysis: lessons from the study of Alzheimers Disease, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005, 573, 1-2, 152
- 24, , In search of genes involved in neurodegenerative disorders, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005, 592, 1-2, 89
- 25, , , , , Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005, 136B, 1Direct Link:
- 26, , , , , , , , , , , , Sequence variants of IDE are associated with the extent of β-amyloid deposition in the Alzheimer's disease brain, Neurobiology of Aging, 2005, 26, 6, 795
- 27, , , , , Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease, Neurobiology of Aging, 2005, 26, 8, 1161
- 28, , , , , , , , , Towards compendia of negative genetic association studies: an example for Alzheimer disease, Human Genetics, 2005, 119, 1-2, 29
- 29, , Twenty Years of the Alzheimerâs Disease Amyloid Hypothesis: A Genetic Perspective, Cell, 2005, 120, 4, 545
- 30
- 31, Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism, Clinical Genetics, 2004, 66, 1Direct Link:
- 32, , , , Endoplasmic Reticulum-Localized Amyloid β-Peptide is Degraded in the Cytosol by Two Distinct Degradation Pathways, Traffic, 2004, 5, 2Direct Link:
- 33, , , , , , , , , , , , Familial clustering and genetic risk for dementia in a genetically isolated Dutch population, Brain, 2004, 127, 7, 1641
- 34, , , , , , , , Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer disease, Human Mutation, 2004, 23, 4Direct Link:
- 35, , , , , , , , , , , , , , Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to β-amyloid metabolism, Human Mutation, 2004, 23, 4Direct Link:
- 36, , , , , , Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease, Neuroscience Letters, 2004, 358, 3, 220
- 37, , , Genetics of neurological disorders, Expert Review of Molecular Diagnostics, 2004, 4, 3, 317
- 38, , Molecular genetics of Alzheimerâs disease, Current Psychiatry Reports, 2004, 6, 2, 125
- 39, Molecular Genetics of Late-Onset Alzheimer's Disease, Annals of Human Genetics, 2004, 68, 4Direct Link:
- 40, Finding and using haplotype blocks in candidate gene association studies, Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics,Direct Link:

1098-1004/asset/HUMU_left.gif?v=1&s=4065e12063da1c0efe3c1a74d4f13c3cd92fba18)
1098-1004/asset/HUMU_right.gif?v=1&s=58026811b6aa5bee5a3d0e0563a705f8b681f34d)
1098-1004/asset/cover.gif?v=1&s=b02ab57a64d28403f477b09d50f72a4d63f4c8eb)