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Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation†

  1. Mannis van Oven*,
  2. Manfred Kayser

Article first published online: 13 OCT 2008

DOI: 10.1002/humu.20921

Issue

Human Mutation

Human Mutation

Volume 30, Issue 2, pages E386–E394, February 2009

Additional Information

How to Cite

van Oven, M. and Kayser, M. (2009), Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum. Mutat., 30: E386–E394. doi: 10.1002/humu.20921

Author Information

  1. Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands

*Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

  1. †

    Communicated by Peter J. Oefner

Publication History

  1. Issue published online: 28 JAN 2009
  2. Article first published online: 13 OCT 2008
  3. Manuscript Accepted: 11 SEP 2008
  4. Manuscript Received: 23 JUL 2008

Funded by

  • Netherlands Forensic Institute

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Keywords:

  • mitochondrial DNA;
  • phylogenetic tree;
  • haplogroup;
  • mtDNA variation;
  • human evolution

Abstract

Human mitochondrial DNA is widely used as tool in many fields including evolutionary anthropology and population history, medical genetics, genetic genealogy, and forensic science. Many applications require detailed knowledge about the phylogenetic relationship of mtDNA variants. Although the phylogenetic resolution of global human mtDNA diversity has greatly improved as a result of increasing sequencing efforts of complete mtDNA genomes, an updated overall mtDNA tree is currently not available. In order to facilitate a better use of known mtDNA variation, we have constructed an updated comprehensive phylogeny of global human mtDNA variation, based on both coding- and control region mutations. This complete mtDNA tree includes previously published as well as newly identified haplogroups, is easily navigable, will be continuously and regularly updated in the future, and is online available at http://www.phylotree.org. © 2008 Wiley-Liss, Inc.

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