Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Authors

  • Xiaomu Wei,

    1. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA
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  • Angela Moncada-Pazos,

    1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain
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  • Santiago Cal,

    1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain
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  • Clara Soria-Valles,

    1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain
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  • Jared Gartner,

    1. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA
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  • Udo Rudloff,

    1. Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
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  • Jimmy C. Lin,

    1. Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
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  • NISC Comparative Sequencing Program,

    1. NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
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  • Steven A. Rosenberg,

    1. Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
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  • Carlos López-Otín,

    1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain
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  • Yardena Samuels

    Corresponding author
    1. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA
    • Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA
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Errata

This article is corrected by:

  1. Errata: Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression Volume 27, Issue 4, 251–252, Article first published online: 28 February 2013

  • Communicated by Georgia Chenevix-Trench

Abstract

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression. © 2011 Wiley-Liss, Inc.

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