Communicated by Georgia Chenevix-Trench
Mutation in Brief
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma†
Article first published online: 24 FEB 2011
© 2011 Wiley-Liss, Inc.
Volume 32, Issue 6, pages E2148–E2175, June 2011
How to Cite
Wei, X., Moncada-Pazos, A., Cal, S., Soria-Valles, C., Gartner, J., Rudloff, U., Lin, J. C., NISC Comparative Sequencing Program, Rosenberg, S. A., López-Otín, C. and Samuels, Y. (2011), Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Hum. Mutat., 32: E2148–E2175. doi: 10.1002/humu.21477
- Issue published online: 25 MAY 2011
- Article first published online: 24 FEB 2011
- Manuscript Accepted: 1 FEB 2011
- Manuscript Received: 7 JUL 2010
Vol. 27, Issue 4, 251–252, Article first published online: 28 FEB 2013
- Cited By
- Somatic mutation;
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression. © 2011 Wiley-Liss, Inc.