These authors contributed equally to this work.
Novel LOVD databases for hereditary breast cancer and colorectal cancer genes in the Chinese population†
Article first published online: 20 OCT 2011
© 2011 Wiley Periodicals, Inc.
Volume 32, Issue 12, pages 1335–1340, December 2011
How to Cite
Pan, M., Cong, P., Wang, Y., Lin, C., Yuan, Y., Dong, J., Banerjee, S., Zhang, T., Chen, Y., Zhang, T., Chen, M., Hu, P., Zheng, S., Zhang, J. and Qi, M. (2011), Novel LOVD databases for hereditary breast cancer and colorectal cancer genes in the Chinese population. Hum. Mutat., 32: 1335–1340. doi: 10.1002/humu.21588
Communicated by Mark H. Paalman
- Issue published online: 14 NOV 2011
- Article first published online: 20 OCT 2011
- Accepted manuscript online: 7 SEP 2011 03:42PM EST
- Manuscript Accepted: 28 JUL 2011
- Manuscript Received: 1 MAY 2011
- National Natural Science Foundation of China (30872955)
- 985 Project Grant from the Ministry of Education of China (Dr. Ming Qi)
- “Qiangjiang Research Talent” (Dr. Ming Qi) from the Science and Technology Department of Zhejiang Province
- Zhejiang Provincial Natural Science Foundation (Ying Yuan) (R2090353)
- breast cancer;
- Lynch syndrome;
- tumor suppressor gene
The Human Variome Project (HVP) is an international consortium of clinicians, geneticists, and researchers from over 30 countries, aiming to facilitate the establishment and maintenance of standards, systems, and infrastructure for the worldwide collection and sharing of all genetic variations effecting human disease. The HVP-China Node will build new and supplement existing databases of genetic diseases. As the first effort, we have created a novel variant database of BRCA1 and BRCA2, mismatch repair genes (MMR), and APC genes for breast cancer, Lynch syndrome, and familial adenomatous polyposis (FAP), respectively, in the Chinese population using the Leiden Open Variation Database (LOVD) format. We searched PubMed and some Chinese search engines to collect all the variants of these genes in the Chinese population that have already been detected and reported. There are some differences in the gene variants between the Chinese population and that of other ethnicities. The database is available online at http://www.genomed.org/LOVD/. Our database will appear to users who survey other LOVD databases (e.g., by Google search, or by NCBI GeneTests search). Remote submissions are accepted, and the information is updated monthly. 32:1335–1340, 2011. ©2011 Wiley Periodicals, Inc.